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Funktionelle Charakterisierung von plasmatischem und rekombinantem von-Willebrand-Faktor durch Bindung an Collagen

  • Conference paper
28. Hämophilie-Symposion Hamburg 1997

Zusammenfassung

Dem von-Willebrand-Faktor (vWF) kommt neben seiner Bedeutung als Carrier und Stabilisator für Faktor VIII eine bedeutende Funktion in der primären Hämostase zu. Hier fungiert er als Bindeglied zwischen spezifischen Rezeptoren der Thrombozytenoberfläche und Komponenten der extrazellulären Matrix wie beispielsweise Collagen. Seine Domänenstruktur wird in Abbildung 1 wiedergegeben. Die Collagenbindungsepitope befinden sich innerhalb eines Disulfid-Loops der A1- bzw. A3-Domane der reifen Untereinheit des vWF [1].

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Authors
  1. J. Siekmann
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  2. P. L. Turecek
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  3. H. P. Schwarz
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Editor information

Editors and Affiliations

  1. Zentr. d. Inn. Med., Med. Klinik I Universitätsklinikum, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany

    Inge Scharrer

  2. Hämostaseologische Abteilung, Med. Univ.-Klinik Innenstadt, Ziemssenstraße 1a, D-80336, München, Germany

    Wolfgang Schramm

  3. Hämophilieambulanz, Zentrum, Innere Medizin, Klinikum der Johann-Wolfgang, Goethe-Universität, Frankfurt am Main, Germany

    Inge Scharrer

  4. Abt. Hämostaseologie, Medizinische Klinik Innenstadt, Ludwig-Maximilians-Universität, München, Germany

    Wolfgang Schramm

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© 1999 Springer-Verlag Berlin Heidelberg

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Siekmann, J., Turecek, P.L., Schwarz, H.P. (1999). Funktionelle Charakterisierung von plasmatischem und rekombinantem von-Willebrand-Faktor durch Bindung an Collagen. In: Scharrer, I., Schramm, W. (eds) 28. Hämophilie-Symposion Hamburg 1997. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59915-6_18

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  • DOI: https://doi.org/10.1007/978-3-642-59915-6_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-64581-8

  • Online ISBN: 978-3-642-59915-6

  • eBook Packages: Springer Book Archive

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