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Roles of Mitochondria in Apoptosis

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Mitochondrial Diseases

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Abstract

Programmed cell death appears as a very early event in the course of evolution, limiting the size cellular populations and eliminating some undesirable cells (Ellis et al. 1991). This process is fundemental for the development of multicellular organisms, in the course of which many embryonic cells die. Programmed cell death and proliferation helps determine the size and form of organs, as well as the functional maturation of some systems. During the development of limbs, cell profileration and differentiation allow the appearance and the growth of limb buds, while the morphogenesis of fingers and toes invokes the death cells initially located in interdigital positions. During the development of the nervous system, neurons that do not reach their target are eliminated by a process of programmed cell death (Thompson 1995). This death allows the establishment of functions of the nervous system by playing on its plasticity. The functional maturation of the immune system also involves massive programmed cell death. The clones of self-reactive T lymphocytes are eliminated by a process of programmed cell death. In other cases, structures whose physiological role is only transitory are eliminated, for example during the metamorphosis of amphibians (tail of tadpoles) and insects (intersegmental muscles).

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  1. CNRS UPRES-A 8087, Université de Versailles/Saint-Quentin, 78035, Versailles, France

    B. Mignotte

  2. CNRS UPR420, IRC, 94800, Villejuif, France

    G. Kroemer

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  1. E 99-29 INSERM, Physiologie Mitochondriale, Université Victor Segalen Bordeaux 2, 146, rue Léo Saignat, 33076, Bordeaux Cedex, France

    Patrick Lestienne (Directeur de Recherche INSERM) (Directeur de Recherche INSERM)

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Mignotte, B., Kroemer, G. (1999). Roles of Mitochondria in Apoptosis. In: Lestienne, P. (eds) Mitochondrial Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59884-5_18

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  • DOI: https://doi.org/10.1007/978-3-642-59884-5_18

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