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Transplantation in the Central Nervous System

  • Chapter
Transplantation Pathology

Part of the book series: Current Topics in Pathology ((CT PATHOLOGY,volume 92))

  • 94 Accesses

Abstract

Cells and tissues have been transplanted into the central nervous system (CNS) for a wide range of purposes. These include: (1) studies of factors controlling cell division, migration, growth and differentiation in the CNS; (2) the elucidation of mechanisms of disease; and (3) a means of restoring neurological function, both in animal models of human disease and, increasingly, in human patients. Although the first attempts at CNS transplantation date back to the last century [151], most of the significant scientific contributions in this field have been made during the past two decades. This period has also seen considerable technical advances, including improvements in the methods for obtaining, purifying and storing donor cells and tissues [5,119], the introduction of more effective immunosuppressive protocols for overcoming graft rejection [13,15,57,71,72,109], and the development of techniques for introducing, into donor cells, genes that express marker proteins, oncogenes, enzymes for neurotransmitter synthesis, and a range of neurotrophic factors. The result has been a rapid increase in the amount of reseach and the number of publications in this field. In this chapter, after a brief review of the history of CNS transplantation, the burgeoning literature on its diverse application is summarised in the context of the different biological and disease processes that have been studied or treated using this technique.

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  1. S. Love
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C. L. Berry

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Love, S., Hilton, D.A. (1999). Transplantation in the Central Nervous System. In: Berry, C.L. (eds) Transplantation Pathology. Current Topics in Pathology, vol 92. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59877-7_8

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