Abstract
Fragrances are ubiquitously used to refine cosmetic, hygiene and household products such as soaps, shampoos, lotions, facial and toilet tissues, household cleansers and detergents but also medicaments, food, plastics, paper, or paints (Tables 1 and 2) [25,27, 34, 37, 49, 53, 74, 83]. Until the last century, natural extracts from plants and animal secretions have been the only source of raw materials for fragrances. Today, approximately 3000 synthetic and 300-400 natural fragrances are used in fragrance industry [6]. Natural fragrances are commonly extracted from essential plant oils and animal secretions (isolates), tree bark (balsams), or are obtained by solvent extraction from plant materials (concretes, absolutes [33]). Well known examples of isolates are eugenol from cloverleaf, citral from lemmon grass and menthol from peppermint oil [65]. In general, many fragrances are viscous, oily substances. However, they are very heterogeneous regarding their chemical structures. Fragrances can be classified for example as terpenes, aromatics, aliphatics, as well as alicyclics and heterocyclics [38,65].
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References
Aiba S, Katz SI (1990) Phenotypic and functional characteristics of in-vivo activated Langerhans cells. J Immunol 145:2791–2796
Aldridge RD, Milton JI, et al. (1985) Leukocyte procoagulant activity as an in-vitro index of nickel contact hypersensitivity. Int Arch Allergy Appl Immunol 76:350–353
Baron JM, Merk HF, et al. (1998) Cytochrome P450 1B1 is a major P450 isoenzyme in human blood monocytes and macrophage subsets. Biochem Pharmacol (in press)
Basketter DA (1992) Skin sensitisation to cinnamic alcohol: the role of skin metabolism. Arch Derm Venerol 72:264–265
Basketter DA, Pendlington RU, et al. (1996) The role of P450 1 A in the activation of prophaptens in skin sensitization. J Invest Dermatol 106:915
Bauer, K, Garbe, D, et al. (1990) Common fragrance and flavor materials: preparation, properties and uses. VCH Verlagsgesellschaft, Weinheim, Germany
Bierer BE, Burakoff SJ (1988) T cell adhesion molecules. FASEB J 2:2584–2590
Bloom BR, Bennett B (1966) Mechanism of a reaction in vitro associated with delayed hypersensitivity. Science 153:80–82
Bottomly K (1988) A functional dichotomy in CD4+ T lymphocytes. Immunology Today 9(9) 268–274
Breitmeyer IB (1987) Lymphocyte activation. How T cells communicate. Nature 329:760–761
Brüning T (1994) A nonradioactive lymphocyte proliferation assay for diagnostics of cellular immune defects in a clinical laboratory. Klin Lab 40:917–927
Byers VS, Epstein WL, et al. (1979) In vitro studies of poison oak immunity. I. In vitro reaction of human lymphocytes to urushiol. J Clin Invest 64:1437–1448
Caron GA, Sarkany I, et al. (1965) Radioactive method for the measurement of lymphocyte transformation in vitro. Lancet 11:1266–1268
Cartwright T, Shah GP (1994) Culture media. In: Davis JM (ed) Basic cell culture. A practical approach. Oxford University Press, New York, pp.57–91
Caux C, Massacrier C, et al. (1995) Human dendritic Langerhans cells generated in vitro from CD34+ progenitors can prime naive CD4+ T cells and process soluble antigen. J Immunol 155:5427–5435
Cederbrant K, Hultman P, et al. (1997) In vitro lymphocyte proliferation as compared to patch test using gold, palladium and nickel. Int Arch Allergy Immunol 112(3)212–217
Cooke MA (1991) IFRA and the dermatologist. Contact Dermatitis 25:209–210
Cooke MA, Cadby PA, et al. (1989a) Databases in the perfumery industry. Semin Dermatol 8:85–87
Cooke MA, Cadby PA, et al. (1989b) Data generation from perfume ingredient safety evaluation. In: Frosch PJ (ed) Current topics in contact dermatitis, Springer-Verlag, Heidelberg, 122–126
Coombs RRA, Gell PGH (1975) Classification of allergic reactions for clinical hypersensitivity and desease. In: Gell PGH, Coombs RRA, Lachman R (eds) Clinical aspects of immunology. Oxford Blackwell Scientific, London, pp. 761–781
Cooper HL, Rubin AD (1965) RNA metabolism in lymphocytes stimulated by phytohemagglutinin: initial responses to phytohemagglutinin. Blood 25:1014–1027
Croft M, Swain SL (1995) Recently activated naive CD4 T cells can help resting B cells, and can produce sufficient autocrine IL-4 to drive differentiation to secretion of T helper 2-type cytokines. J Immunol 154:4269–4282
De Groot AC, Liem DH (1983) Contact urticaria to rouge. Contact Dermatitis 9:322
De Groot AC, Frosch PJ (1997) Adverse reactions to fragrances. Contact Dermatitis 36:57–86
De Groot AC, Baar AIM, et al. (1991) Contact allergy to moist toilet paper. Contact Dermatitis 24:135–136
De Groot AC, Weyland JW, et al. (1994) Unwanted effects of cosmetics and drugs used in dermatology. Amsterdam, Elsevier
Dooms-Goossens A, Dubelloy R, et al. (1990) Contact and systemic contact-type dermatitis to spices. In: Adams RM, Nethercott JR (eds) Dermatologie Clinics. Contact Dermatitis. WB Saunders Company, Philadelphia, pp. 89–93
Egner W, Hart DNJ (1995) The phenotype of freshly isolated and cultured human bone marrow allostimulatory cells: possible heterogeneity in bone marrow dendritic cell populations. Immunology 85:611
Enders F, Przybilla B, et al. (1991) Patch testing with fragrance-mix and its constituents: discrepancies are largely due to the presence or absence of sorbitan sesquioleate. Contact Dermatitis 24:238
Enk AH, Katz SI (1992) Early molecular events in the induction phase of contact sensitivity. Proc Natl Acad Sci USA 89:1398–1402
Everness KM, Gawkrodger DJ, et al. (1990) The discrimination between nickel-sensitive and nonnickel-sensitive subjects by an in vitro lymphocyte transformation test. Br J Dermatol 122:293–298
Fenn RS (1989) Aroma chemical usage trends in modern perfumery. Perfumer and Flavorists 14:3–10
Fischer T (1995) Perfumed products. In: GuIn ID (ed) Practical contact dermatitis. McGraw-Hill, New York, pp. 355–371
Fisher AA (1973) Allergic reactions to feminine hygiene sprays. Arch Dermatol 108:801–803
Giovinazzo VJ, Harber LC, et al. (1981) Photoallergic contact dermatitis to musk ambrette. Histopathological features of photobiologic reactions observed in a persistent light reactor. Arch Dermatol 117:344–348
Goncalo S, Gil I, et al. (1991) Pigmented photoallergic contact dermatitis from musk ambrette. Contact Dermatitis 24:229–230
Guin ID (1981) Contact dermatitis to perfume in paper products. J Am Acad Dermatol 4:733–734
Hausen B (1996) Lexikon der Kontaktallergene. Ecomed Verlag, Landsberg, Germany
Hayakawa R, Matsunaga K, et al. (1987) Airborne pigmented contact dermatitis due to musk ambrette in incense. Contact Dermatitis 16:96–98
Hayakawa R, Hirose O, et al. (1991)Pigmented contact dermatitis due to musk moskene.J Dermatol 18:420–421
Hirschberg H, Braathen LR, et al. (1982) Antigen presentation by vascular endothelial cells and epidermal Langerhans cells: the role of HLA-DR. Immunol Rev 65:57–77
Hoffman KM, Ho DG, et al. (1997) Evaluation of the usefulness of lymphocyte proliferation assays in the diagnosis of allergy to cow’s milk. J Allergy Clin Immunol 99(3)360–366
lenkins MK, Johnson JG (1993) Molecules involved in T-cell costimulation. Curr Opin Immunol 5:361–367
Jonuleit H, Müller G, et al. (1996) IL-1-β upregulation in dendritic cells by contact sensitizers: generation of an in vitro test system for contact allergens (Abstr.). Arch Dermatol Res 288:279
Jonuleit H, Kiihn U, et al. (1997) Pro-inflammatory cytokines and prostaglandins induce maturation of potent immunostimulatory dendritic cells under fetal calf serum-free conditions. Eur J Immunol 24: (in press)
Jordan WP, Dvorak J (1976) Leukocyte migration inhibition assay (LIF) in nickel contact dermatitis. Arch Dermatol 112:1741–1744
Kalish RS, Morimoto C (1989) Quantitation and cloning of human urushiol specific peripheral blood T-cells: isolation of urushiol triggered suppressor T-cells. J Invest Dermatol 92:46–52
Kapsenberg ML, Res P, et al. (1987) Nickel-specific T lymphocyte clones derived from allergic nickel-contact dermatitis lesions in man: heterogeneity based on requirement of dendritic antigenpresenting cell subsets. Eur J Immunol 17:861–865
Keith L, Erich W, et al. (1969) Toilet paper dermatitis. JAMA 209:269
Kelso A (1995) Thl and Th2 subsets: paradigms lost? Immunology Today 16(8)374–379
Kimber I, Quirke S, et al. (1991) Lymphocyte transformation and thiuram sensitization. Contact Dermatitis 24:164–171
Landsteiner K, Jacobs JL (1936) Studies on the sensitization of animals with simple chemicals. J Exp Med 64:625–639
Larsen WG (1979) Allergic contact dermatitis to the perfume in Mycolog cream. J Am Acad Dermatol 1:131–133
Larsen WG (1985) Perfume dermatitis. J Am Acad Dermatol 12(l):l–9
Levis WR, Whalen J J, et al. (1976) Specific blastogenesis and lymphokine production in DNCB-sensitive human leucocyte cultures stimulated with soluble and particulate DNP-containing antigens. Clin Exp Immunol 23:481–490
Mackinney AA, Stoklman F, et al. (1962) The kinetics of cell proliferation in cultures of human peripheral blood. Blood 19:349–358
Magaud J-P, Sargent I, et al. (1988) Detection of human white cell proliferative responses by immunoenzymatic measurement of bromodeoxyuridine uptake. J Immunol Meth 106:95–100
Malanin G, Ohela K (1989) Allergic reactions to fragrance mix and its components. Contact Dermatitis 21:62–63
McAteer JA, Davis J (1994) Basic cell culture technique and the maintenance of cell lines. In: Davis JM (ed) Basic cell culture A practical approach. Oxford University Press, New York, pp. 93–148
McDaniel WR, Marks JG (1979) Contact urticaria due to sensitivity to spray starch. Arch Dermatol 115:628
Merk HF (1996) Skin metabolism in allergic contact dermatitis: the molecular basis. Springer Verlag, Berlin, Heidelberg, New York, pp 86–80
Mosman TR (1989) Thl and Th2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7:145–173
Mosmann TR, Cherwinski H, et al. (1986) Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 136(7)2348–357
Müller G, Knop J, et al. (1996) Is cytokine expression responsible for differences between allergens and irritants? Am J Contact Dermatitis 7(3)177–184
Muller PM, Lamparsky D (1991) Perfumes: art, science, and technology. Elsevier, New York
Murphy E, Shibuya K, et al. (1986) Reversibility of T helper 1 and 2 populatoins is lost after longterm stimulation. J Exp Med 183:901–913
Nowell PC (1960) Phytohemagglutinin, an initiator of mitosis in cultures of normal human leucocytes. Cancer Res 20:462–466
Nyfeler B, Pichler WJ (1997) The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity. Clin and Exp Allergy 27:175–181
Oppenheim JJ (1969) Immunological relevance of antigen and antigen antibody complex induced lymphocyte transformation. Ann Allergy 27:305–315
Räsänen L, Tuomi M-L (1992) Diagnostic value of the lymphocyte proliferation test in nickel contact allergy and provocation in occupational coin dermatitis. Contact Dermatitis 27:250–254
Reid CDL, Stackpoole A,et al. (1992) Interactions of tumor necrosis factor with granulocyte-macrophage colony-stimulating factor and other cytokines in the regulation of dendritic cell growth in vitro from early bipotent CD34+ progenitors in human bone marrow. J Immunol 149:2681
Romani N, Gruner S, et al. (1994) Proliferating dendritic cell progenitors in human blood. J Exp Med 180:83–93
Romani N, Reider D, et al. (1996) Generation of mature dendritic cells from human blood. An improved method with special regard to clinical applicability. J Immunol Meth 196:137–151
Rothenborg HW, Hjorth N (1968) Allergy to perfumes from toilet soaps and detergents in patients with dermatitis. Arch Dermatol 97:417–421
Rytter M, Hausten U-F (1982) Hapten conjugation in the leukocyte migration inhibition test in allergic chromate eczema. Br J Dermatol 106:161–168
Sallusto F, Lanzavecchia A (1994) Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor a. J Exp Med 179:1109–1118
Scheinmann PL (1996) Allergic contact dermatitis to fragrance: a review. Am J Contact Dermatitis 7:65–76
Serrano G, Pujol C, et al. (1989) Pigmented contact dermatitis caused by fragrances. J Am Acad Dermatol 21:1057–1060
Sieben S, Al Masaoudi T, et al. (1998) Phase I and II enzyme expression in human monocytes, dendritic cells and keratinocytes (abstract 358). 12th International Symposium in Microsomes and Drug Oxidation, July 20-24, Montpellier
Sinigaglia F, Scheidegger D, et al. (1985) Isolation and characterization of Ni-specific T cell clones from patients with Ni-contact dermatitis. J Immuno 135:3929–3932
Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immunol 9:271–296
Tio D (1976) A study on the clinical application of a direct leukocyte migration test in chromium contact allergy. Br J Dermatol 94:65–70
Veien NK, Hattel T, et al. (1987) Dietary restrictions in the treatment of adult patients with eczema. Contact Dermatitis 17:223–227
Von Blomerg-van der Flier BME, Bruynzeel DP, et al. (1988) Impact of 25 years of in vitro testing in allergic contact dermatitis. In: Frosch PJ, Dooms-Goossens A, Lachapelle J-M, et al. (eds) Current topics in contact dermatitis. Springer-Verlag, Berlin Heidelberg New York, pp. 569–577
Wheelock EF (1965) Interferon-like virus inhibitor induced in human leukocytes by phytohemagglutinin. Science 149:310–311
Williams WR, Williams WJ (1982) Comparison of lymphocyte transformation and macrophage migration inhibition tests in the detection of beryllium sensitivity. J Clin Pathol 35:684–687
Yamada M, Niwa Y, et al. (1972) Lymphocyte transformation in allergic contact dermatitis. Jpn J Dermatol 82:94–97
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Sieben, S., Blömeke, B., Merk, H.F. (1999). Fragrances Between Allergic, Hypoallergic,and Irritant: In Vitro Studies. In: Elsner, P., Maibach, H.I., Merk, H.F. (eds) Cosmetics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59869-2_20
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DOI: https://doi.org/10.1007/978-3-642-59869-2_20
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