Abstract
Scarred lesions and strictures involving the acral portions of fingers and toes may cause a deficiency of peripheral blood flow. If the blood supply to the bone is significantly impaired, osteolytic lesions may develop (e.g., in the terminal tufts of the distal phalanges). The precipitating causes are usually chronic and traumatic in nature (see below). Acute traumatization by heat, cold, electric shock, etc. is relatively uncommon. The pathogenesis of acro-osteolysis occurring in systemic diseases with peripheral blood flow disturbances (e.g., progressive scleroderma, hypertrophic osteoarthropathy; Table 8.1) is ultimately the same as in nonsystemic causes: whenever the “principal players” in bone remodeling, the osteoclasts and osteoblasts, are deprived of nutrition, the balance between production and resorption is tipped toward lysis, and bone substance is lost.
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Freyschmidt, J., Freyschmidt, G. (1999). Other Diseases. In: SKIBO-Diseases Disorders Affecting the Skin and Bones. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59867-8_9
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DOI: https://doi.org/10.1007/978-3-642-59867-8_9
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