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Transgenic Animals

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Techniques in Molecular Medicine

Part of the book series: Springer Lab Manual ((SLM))

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Abstract

In recent years, the roles of genes involved in the pathogenesis of numerous diseases have been elucidated. Several of these genes have been sufficiently well characterized to permit experiments in vivo by introducing genomic fragments or DNA-constructs into animals. These transgenic animals can then become valuable models that offer new approaches to understand the genetic basis of disease. Some of the possible strategies in transgenic animal research are the expression of homologous or heterologous genes under their endogenous promoter, the expression of a reporter gene under a specific promoter or the tissue-specific expression using tissue-specific cis-acting regulatory elements. Another possibility is the generation of gene “knock-outs” using homologous recombination in embryonic stem cells.

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Authors and Affiliations

  1. Max-Delbrück-Center for Molecular Medicine, Robert Rössle Straβe 10, Berlin, 13122, Germany

    Eckart Schott, Martin Paul & Detlev Ganten

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  1. Eckart Schott
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  2. Martin Paul
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Correspondence to Detlev Ganten .

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Editors and Affiliations

  1. Universitäts-Kinderklinik, Mathildenstrasse 1, D-79106, Freiburg, Germany

    Friedhelm Hildebrandt

  2. Section of Nephrology, Dep. of Internal Medicine, Yale University, 2073 Laboratory of Medicine and Pediatrics, 333 Cedar Street, New Haven, Connecticut, 06620-8029, USA

    Peter Igarashi M.D.

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© 1999 Springer-Verlag Berlin Heidelberg

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Schott, E., Paul, M., Ganten, D. (1999). Transgenic Animals. In: Hildebrandt, F., Igarashi, P. (eds) Techniques in Molecular Medicine. Springer Lab Manual. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59811-1_21

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  • DOI: https://doi.org/10.1007/978-3-642-59811-1_21

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