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Regulation of Gene Expression by Changes in Cell Adhesion

  • Chapter
Signaling Through the Cell Matrix

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 25))

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Abstract

It is generally accepted that the interaction of cells with their extracellular environment is crucial for their coordinated functions and homeostasis. Differentiation and proliferation are highly coordinated events and represent the most basic behavior of cells. Biological signals to control cellular differentiation and proliferation are initiated by extracellular molecules, which can be divided into two classes based on their solubility. The soluble class includes hormones, growth factors, and cytokines, which circulate in the whole body or diffuse locally and bind to the specific receptors of target organs. The soluble factors are major and potent regulators, and their concentration in serum is finely controlled by integrated biological systems. The insoluble class is represented by (1) cell-cell interaction with adjacent cells and (2) cell adhesion to the extracellular matrix (ECM) (Gumbiner 1996). The insoluble factors are static regulators in comparison with the soluble factors, but have been found to play a critical role in the control of proliferation, differentiation, and morphogenesis.

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Authors and Affiliations

  1. Department of Biochemistry, Yamagata University School of Medicine, Yamagata, 990-9585, Japan

    Takejiro Kuzumaki

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  1. Takejiro Kuzumaki
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Editors and Affiliations

  1. University of Paris VI, 73 bis rue Maréchal Foch, 78000, Versailles, France

    Alvaro Macieira-Coelho

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© 2000 Springer-Verlag Berlin Heidelberg

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Kuzumaki, T. (2000). Regulation of Gene Expression by Changes in Cell Adhesion. In: Macieira-Coelho, A. (eds) Signaling Through the Cell Matrix. Progress in Molecular and Subcellular Biology, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59766-4_5

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  • DOI: https://doi.org/10.1007/978-3-642-59766-4_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67220-3

  • Online ISBN: 978-3-642-59766-4

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