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The Transmission of Contractility Through Cell Adhesion

  • Chapter
Signaling Through the Cell Matrix

Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 25))

Abstract

Living cells generate active tension within their internal cytoskeleton and exert on the adhesive sites with extra cellular matrix (ECM). This mechanical linkage is necessary not only for supporting the cell shape or position, but also for cell migration. (Harris, Stopak et a1.1981; Sheetz 1994; Lauffenburger and Horwitz 1996; Mitchison and Cramer 1996) Furthermore, it is becoming clear that the internal stress field of the cell, resulting from the balancing of generation and exertion forces, can influence a number of cellular functions, including growth, differentiation, apoptosis, and signal tranduction (reviewed in Shyy and Chien 1997; Chicurel et al.1997). Cells are also interconnected with neighboring cells and transmitting forces to their neighbors. These mechanical interactions between groups of cells and the ECM, which joins these cells together, are important in tissue structure maintenance, physiological organ function, morphogenesis, and wound healing.

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  1. Department of Pathology, Mie University School of Medicine, 2-174 Edobashi, Tsu, Mie, 514-8507, Japan

    Kyoko Imanaka-Yoshida

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  1. University of Paris VI, 73 bis rue Maréchal Foch, 78000, Versailles, France

    Alvaro Macieira-Coelho

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Imanaka-Yoshida, K. (2000). The Transmission of Contractility Through Cell Adhesion. In: Macieira-Coelho, A. (eds) Signaling Through the Cell Matrix. Progress in Molecular and Subcellular Biology, vol 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59766-4_2

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  • DOI: https://doi.org/10.1007/978-3-642-59766-4_2

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-67220-3

  • Online ISBN: 978-3-642-59766-4

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