Skip to main content
SpringerLink
Log in

Irritative Kontaktdermatitis

  • Conference paper
Nutzen und Risiko von Kosmetika

  • 227 Accesses

Zusammenfassung

Die irritative Kontaktdermatitis ist eine nichtimmunologisch vermittelte entzündliche Reaktion uneinheitlicher Pathogenese, die bereits nach dem ersten Kontakt der Haut mit Irritanzien entstehen kann. Neben der individuellen Empfindlichkeit entscheidet v. a. die Dosis des Irritans über das Ausmaß der Reaktion. Demgegenüber beruhen allergische Reaktionen auf einer immunologischen Sensibilisierung, die zumeist erst nach wiederholter Exposition auftreten und je nach Sensibilisierungsgrad des Individuums auch bereits durch sehr geringe Mengen des Allergens ausgelöst werden können.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 59.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 79.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Andersen KE, Benezra C, Burrows D et al. (1987) Contact Dermatitis. A review. Contact Dermatitis 16: 55–78.

    Article  CAS  Google Scholar 

  • Basketter DA, Wilhelm KP (1996) Studies on non-immune immediate contact reactions in an unselected population. Contact Dermatitis 35: 237–240.

    Article  PubMed  CAS  Google Scholar 

  • Bettley FR, Donoghue E (1960) The irritant effect of soap upon the normal skin. Br J Dermatol 72: 67–76.

    Article  PubMed  CAS  Google Scholar 

  • Brand CU, Hunziker T, Braathen LR (1992) Isolation of human skin-derived lymph: Flow and output of cells following sodium lauryl sulphate-induced contact dermatitis. Arch Dermatol Res 284:123–126.

    Article  PubMed  CAS  Google Scholar 

  • Bruynzeel DP, van Ketel WG, Scheper RJ, von Blomberg-van der Flier BME (1982) Delayed time course of irritation by sodium lauryl sulfate: Observation on threshold reactions. Contact Dermatitis 8: 236–239.

    Google Scholar 

  • Cua AB, Wilhelm KP, Maibach HI (1990) Cutaneous sodium lauryl sulfate irritation potential: Age and regional variability. Br J Dermatol 123: 607–613.

    Article  PubMed  CAS  Google Scholar 

  • Downing DT, Abraham W, Wegner BK, Willman KW, Marshall JL (1993) Partition of sodium dodecyl sulfate into stratum corneum lipid liposomes. Arch Dermatol Res 285:151–157.

    Article  PubMed  CAS  Google Scholar 

  • Foussereau J, Cavelier C (1978) Toxische Dermatitis und Pseudo-Kontaktallergie. Dermatosen 26: 156–161.

    CAS  Google Scholar 

  • Froebe CL, Simion FA, Rhein LD, Cagan RH, Kligman AM (1990) Stratum corneum lipid removal by surfactants: Relation to in vivo irritation. Dermatologica 181: 277–283.

    Article  PubMed  CAS  Google Scholar 

  • Frosch PJ (1985) Hautirritation und empfindliche Haut. Grosse Scripta 7, Grosse, Berlin.

    Google Scholar 

  • Frosch PJ, Czarnetzki BM (1987) Surfactants cause in vitro chemotaxis and chemokinesis of human neutrophils. J Invest Dermatol 88: 52S–55S.

    Article  PubMed  CAS  Google Scholar 

  • Frosch PJ, Kligman AM (1977) A method for appraising the stinging capacity of topically applied substances. J Soc Cosmet Chem 28:197–209.

    Google Scholar 

  • Gollhausen R, Kligman AM (1985) Human assay for identifying substances which induce non-allergic contact urticaria: the NICU-test. Contact Dermatitis 13: 98–106.

    Article  PubMed  CAS  Google Scholar 

  • Guy RH, Wester RC, Tur E, Maibach HI (1983) Noninvasive assessments of the percutaneous absorption of methyl nicotinate in humans. J Pharm Sci 72:1077–1079.

    Article  PubMed  CAS  Google Scholar 

  • Hannuksela M (1997) Cosmetics, cosmetic ingredients, emulsifiers and moisturizers In: Amin S, Lahti A, Maibach HI (eds) Contact Urticaria Syndrome. CRC, Boca Raton, FL, pp 111–113.

    Google Scholar 

  • Imokawa G, Sumura K, Katsumi M (1975) Study on skin roughness caused by surfactants: II. Correlation between protein denaturation and skin roughness. J Am Oil Chem Soc 52: 484–489.

    CAS  Google Scholar 

  • Imokawa G, Akasaki S, Minematsu Y, Kawai M (1989) Importance of intercellular lipids in water-retention properties of the stratum corneum: Induction and recovery study of surfactant dry skin. Arch Dermatol Res 281: 45–51.

    Article  PubMed  CAS  Google Scholar 

  • Jordon JW, Dolce FA, Osborne ED (1940) Dermatitis of the hands in housewives. Role of soap in its etiology and methods for its prevention. JAMA 115:1001–1006.

    CAS  Google Scholar 

  • Kligman AM, Epstein W (1975) Updating the maximization test for identifying contact allergens. Contact Dermatitis 1: 231–239.

    Article  PubMed  CAS  Google Scholar 

  • Kligman AM (1982) Assessment of mild irritants. In: Frost P, Horwitz SN, Principles of cosmetics for the dermatologist. Mosby, London pp 265–274.

    Google Scholar 

  • Lahti A, Maibach HI (1989) Immediate Contact Reactions. Immunology and Allergy Clinics North Am 9: 463–478.

    Google Scholar 

  • Magnusson B, Kligman AM (1977) Factors influencing allergic contact sensitization. In: Marzulli MN, Maibach HI (eds) Dermatotoxicology and Pharmacology. Hemisphere, Washington, pp 289–304.

    Google Scholar 

  • Malten KE (1981) Thoughts on irritant contact dermatitis. Contact Dermatitis 7: 238–247.

    Article  PubMed  CAS  Google Scholar 

  • Malten KE, den Arend JAC (1985) Irritant contact dermatitis. Dermatosen 33:125–132.

    CAS  Google Scholar 

  • Metker C, Welzel J, Wilhelm KP (1995) Epidermal proliferation is related to the integrity of the skin permeability barrier (abstract). Allergologie 17: 262–263.

    Google Scholar 

  • Patrick E, Maibach HI, Burkhalter A (1985) Mechanisms of chemically induced skin irritation. Toxicol Appl Pharmacol 81: 476–490.

    Article  PubMed  CAS  Google Scholar 

  • Proksch E, Elias PM, Feingold KR (1990) Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity in murine epidermis. Modulation of enzyme content and activation state by barrier requirements. J Clin Invest 85: 874–882.

    CAS  Google Scholar 

  • Proksch E, Feingold KR, Mao-Qiang M, Elias PM (1991) Barrier function regulates epidermal DNA synthesis. J Clin Invest 87:1668–1673.

    Article  PubMed  CAS  Google Scholar 

  • Reinartz J, Boukamp P, Schickel E, Fusenig NE, Kramer MD (1991) Activation of the plasminogen activator system in a keratinocyte cell line (HaCaT) by alkyl sulfates. Biomed Biochim Acta 50:743–748.

    PubMed  CAS  Google Scholar 

  • Ring J, Gollhausen R (1990) Allergologische Bewertung von Syndets zur Hautreinigung. In: Braun Falco O, Korting HC (Hrsg) Hautreinigung mit Syndets. Springer, Berlin Heidelberg New York Tokyo, pp 181–188.

    Google Scholar 

  • Scheuplein R, Ross L (1970) Effects of surfactants and solvents on the permeability of epidermis. J Soc Cosmet Chem 21: 853–873.

    CAS  Google Scholar 

  • Van der Valk PGM, Nater JP, Bleumink E (1985) The influence of low concentrations of irritants on skin barrier function as determined by water vapour loss. Dermatosen 33: 89–91.

    Google Scholar 

  • Wilhelm KP, Surber C, Maibach HI (1989) Quantification of sodium lauryl sulfate irritant dermatitis in man. Comparison of four techniques: Skin color reflectance, transepidermal water loss, laser Doppler flow measurement and visual scores. Arch Dermatol Res 281: 293–295.

    Article  PubMed  CAS  Google Scholar 

  • Wilhelm KP, Samblebe M, Siegers CP (1994) Quantitative in vitro assessment of N-alkyl sulfate-induced cytotoxicity in human keratinocytes (HaCaT). Comparison with in vivo human irritation tests. Br J Dermatol 130:18–23.

    CAS  Google Scholar 

  • Wilhelm KP, Freitag G, Wolff HH (1994) Surfactant-induced skin irritation and skin repair: Evaluation of a cumulative human irritation model by non-invasive techniques. J Am Acad Dermatol 31: 981–987.

    Article  PubMed  CAS  Google Scholar 

  • Wilkinson JD, Rycroft RJG (1992) Contact dermatitis. In: Champion RH, Burton JL, Ebling FJG (eds) Textbook of dermatology, 5th edn, Vol 1. Blackwell, Oxford, United Kingdom, pp 611–716.

    Google Scholar 

  • Willis CM, Stephens CJM, Wilkinson JD (1992) Differential effects of structurally unrelated chemical irritants on the density of proliferating keratinocytes in 48I1 patch test reactions. J Invest Dermatol 99:449–453.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. K.-P. Wilhelm
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. Wilhelm
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Dermatologie und Allergologie, Ludwig-Maximilians-Universität München, Frauenlobstraße 9–11, 80337, München, Germany

    O. Braun-Falco  & H. C. Korting  & 

  2. Hautklinik am Städtischen Klinikum Karlsruhe gGmbH, Moltkestraße 120, 76133, Karlsruhe, Germany

    Max Gloor

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Wilhelm, KP., Wilhelm, D. (2000). Irritative Kontaktdermatitis. In: Braun-Falco, O., Gloor, M., Korting, H.C. (eds) Nutzen und Risiko von Kosmetika. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59747-3_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59747-3_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64108-4

  • Online ISBN: 978-3-642-59747-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation