Skip to main content

Postoperative Übelkeit und Erbrechen — Inzidenz, Prophylaxe, Therapie

  • Conference paper
  • 35 Accesses

Part of the book series: Refresher Course Aktuelles Wissen für Anästhesisten ((REFRESHER COUR,volume 26))

Zusammenfassung

Die Bedeutung der postoperativen Übelkeit und des postoperativen Erbrechens (PONV) wird nach wie vor unterschiedlich eingeschätzt. Die Beeinträchtigung des Wohlbefindens des Patienten durch PONV ist unbestritten. Neben der Angst vor dem operativen Eingriff ist die Angst vor Schmerzen und Erbrechen bei den Patienten sehr stark ausgeprägt. Postoperative Übelkeit und postoperatives Erbrechen können, insbesondere nach abdominellen Eingriffen, auch den postoperativen Schmerz verstärken. Darüber hinaus besteht die Gefahr der Aspiration und Störung des Elektrolythaushaltes. Gerade nach ambulanten Anästhesien kann sich eine verlängerte Zeit im Aufwachraum oder die Notwendigkeit der stationären Aufnahme bzw. Wiederaufnahme bei schwerer Übelkeit und schwerem Erbrechen als problematisch erweisen. In ganz seltenen Fällen kommt es durch gehäuftes Erbrechen zur Nahtdehiszenz.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Allen RW (1990) Metoclopramide–a safe anti-emetic? S Afr Med J 77: 219–221

    PubMed  CAS  Google Scholar 

  2. Alon E, Buchser E, Herrera E (1998) Tropisetron for treating established postoperative nausea and vomiting: a randomized, double-blind, placebo-controlled study. Anesth Analg 86: 617–623

    PubMed  CAS  Google Scholar 

  3. Alon E, Himmelseher S (1992) Ondansetron in the treatment of postoperative vomiting: a randomized double-blind comparison with droperidol and metoclopramide. Anesth Analg 75: 561–565

    Article  PubMed  CAS  Google Scholar 

  4. Andrews PLR (1992) Physiology of nausea and vomiting. Br J Anaesth 69 (Suppl 1): S 2-S 19

    Article  Google Scholar 

  5. Borison HL (1989) Area postrema: chemoreceptor circumventricular organ of the medulla oblongata. Prog Neurobiol 32: 351–390

    Article  PubMed  CAS  Google Scholar 

  6. Capouet V, Depauw C, Vernet B (1996) Single dose iv tropisetron in the prevention of postoperative nausea and vomiting after gynaecological. Br J Anaesth 76: 54–60

    PubMed  CAS  Google Scholar 

  7. Cohen SE, Woods WA, Wyner J (1984) Antiemetic efficacy of droperidol and metoclopramide. Anesthesiology 60: 67–69

    Article  PubMed  CAS  Google Scholar 

  8. Cohen MM, Duncan PG, DeBoer DP, Tweed WA (1994) The postoperative interview: assessing risk factors for nausea and vomiting. Anesth Analg 78: 7–16

    Article  PubMed  CAS  Google Scholar 

  9. Diemunsch P, Conseiller C, Clyti N (1997) Ondansetron compared with metoclopramide in the treatment of established postoperative nausea and vomiting. Br J Anaesth 79: 322–326

    PubMed  CAS  Google Scholar 

  10. Diemunsch P, Kortilla K, Leeser J (1998) Oral dolasetron mesylate for prevention of postoperative nausea and vomiting: a multicenter, double-blind, placebo-controlled study. J Clin Anesth 10: 145–152

    Article  PubMed  CAS  Google Scholar 

  11. Fisher DM (1997) The „big little problem“ of postoperative nausea and vomiting: do we know the answer yet? Anesthesiology 87: 1271–1273

    Article  PubMed  CAS  Google Scholar 

  12. Foster PN, Stickle BR, Laurence AS (1996) Akathisia following low-dose droperidol for antiemesis in day case patients. Anaesthesia 51: 491–494

    Article  PubMed  CAS  Google Scholar 

  13. Fujii Y, Tanaka H, Toyooka H (1994) Optimal anti-emetic dose of granisetron for prevention of postoperative nausea and vomiting. Can J Anaesth 41: 794–797

    Article  PubMed  CAS  Google Scholar 

  14. Kapur PA (1991) The big „little problem“. Anesth Analg 73: 243–245

    Article  PubMed  CAS  Google Scholar 

  15. Kauste A, Tuominen M, Heikkinen H (1986) Droperidol, alizapride and metoclopramide in the prevention and treatment of postoperative emetic sequelae. Eur J Anaesthesiol 3: 1–9

    PubMed  CAS  Google Scholar 

  16. Koivuranta M, Jokela R, Kiviluoma K, Alahuhta S (1997) The antiemetic efficacy of a combination of ondansetron and droperidol. Anaesthesia 52: 863–868

    Article  PubMed  CAS  Google Scholar 

  17. Kortilla K, Kauste A, Auvinen J (1979) Comparison of domperidone, droperidol, and metoclopramide in the prevention and treatment of nausea and vomiting after balanced anesthesia. Anesth Analg 66: 761–765

    Google Scholar 

  18. Lawhorn CD, Kymer PJ, Stewart FC, Stoner JM, Shirey R, Volpe P (1997) Ondansetron dose response curve in high-risk pediatric patients. J Clin Anesth 9: 637–642

    Article  PubMed  CAS  Google Scholar 

  19. Lopez-Olaondo L, Carrascosa F, Pueyo FJ, Monedero P, Busto N, Saez A (1996) Combination of ondansetron and dexamethasone in the prophylaxis of postoperative nausea and vomiting. Br J Anaesth 76: 835–840

    PubMed  CAS  Google Scholar 

  20. McKenzie R, Tantisira B, Karambelkar DJ, Riley TJ, Abdelhady H (1994) Comparison of ondansetron with ondansetron plus dexamethasone in the prevention of postoperative nausea and vomiting. Anesth Analg 79: 961–964

    Article  PubMed  CAS  Google Scholar 

  21. Melnick B, Sawyer R (1989) Delayed side effects of droperidol after ambulatory anesthesia. Anesth Analg 69: 748–751

    Article  PubMed  CAS  Google Scholar 

  22. Mikawa K, Takao Y, Nishina K (1995) The antiemetic efficacy of prophylactic granisetron in gynecologic surgery. Anesth Analg 80: 970–974

    PubMed  CAS  Google Scholar 

  23. Naylor RJ, Inall FC (1994) The physiology and pharmacology of postoperative nausea and vomiting. Anaesthesia 49 (Suppl): 2–5

    Article  PubMed  Google Scholar 

  24. Palacios JM, Wamsley JK, Kuhar MJ (1981) The distribution of histamine H1-receptors in the rat brain: an autoradiographic study. Neuroscience 6: 15–17

    Article  PubMed  CAS  Google Scholar 

  25. Pandit SJ, Kothary SP (1989) Dose response study of droperidol and metoclopramide as antiemetics for outpatients anesthesia. Anesth Analg 68: 798–802

    Article  PubMed  CAS  Google Scholar 

  26. Pearman MH (1994) Single dose intravenous ondansetron in the prevention of postoperative nausea and vomiting. Anaesthesia 49: 11–15

    Article  PubMed  Google Scholar 

  27. Polati E, Verlato G, Finco G (1997) Ondansetron vs. metoclopramide in the treatment of postoperative nausea and vomiting. Anesth Analg 85: 395–399

    PubMed  CAS  Google Scholar 

  28. Rose JB, Watcha MF (1999) Postoperative nausea and vomiting in paediatric patients. Br J Anaesth 83: 104–117

    PubMed  CAS  Google Scholar 

  29. Rowbothan DJ (1992) Current management of postoperative nausea and vomiting. Br J Anaesth 69 (Suppl 1): S 46-S 59

    Google Scholar 

  30. Scholz J, Hennes HJ, Steinfath M et al. (1998) Tropisetron or ondansetron compared with placebo for prevention of postoperative nausea and vomiting. Eur J Anaesthesiol 15: 676–685

    Article  PubMed  CAS  Google Scholar 

  31. Scholz J, Steinfath M, Tonner PH (1999) Postoperative nausea and vomiting. Curr Opin Anaesth 12:

    Google Scholar 

  32. Splinter WM, Rhine EJ (1998) Low-dose ondansetron with dexamethasone more effectively decreases vomiting after strabismus surgery in children than does high-dose ondansetron. Anesthesiology 88: 72–75

    Article  PubMed  CAS  Google Scholar 

  33. Stefani E, Clement-Cormier Y (1981) Detection of receptors in the area postrema. Eur J Pharmacol 74: 257–260

    Article  Google Scholar 

  34. Tang J, Wang B, White PF, Watcha MF, Qi J, Wender RH (1998) The effect of timing of ondansetron administration on its efficacy, cost-effectiveness, and cost-benefit as a prophylactic antiemetic in the ambulatory setting. Anesth Analg 86: 274–282

    PubMed  CAS  Google Scholar 

  35. Waeber C, Dixon K, Hoyer D (1988) Localisation by autoradiography of neuronal 5-HT3 receptors in the mouse. Eur J Pharmacol 151: 351–352

    Article  PubMed  CAS  Google Scholar 

  36. Wamsley JK, Lewis MS (1981) Auto radiographic localization of muscarinic cholinergic receptors in rat brainstem. J Neurosci 1: 176–191

    PubMed  CAS  Google Scholar 

  37. Watcha MF, White PF (1992) Postoperative nausea and vomiting. Anesthesiology 77: 162–184

    Article  PubMed  CAS  Google Scholar 

  38. Wilder-Smith OH, Martin NC, Morabia A (1997) Postoperative nausea and vomiting: a comparative survey of the attitudes, perceptions, and practice of Swiss anesthesiologists and surgeons. Anesth Analg 84: 826–831

    PubMed  CAS  Google Scholar 

Download references

Authors

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Scholz, J., Hennes, HJ., Bardenheuer, H.J., Kretz, FJ. (2000). Postoperative Übelkeit und Erbrechen — Inzidenz, Prophylaxe, Therapie. In: Refresher Course Aktuelles Wissen für Anästhesisten. Refresher Course Aktuelles Wissen für Anästhesisten, vol 26. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59720-6_16

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59720-6_16

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-66777-3

  • Online ISBN: 978-3-642-59720-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics