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52. Kongreß der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe pp 399–403Cite as

Klinische Einsatzmöglichkeiten der Molekularbiologie

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Zusammenfassung

Die Präimplantationsdiagnostik bezeichnet die Möglichkeit, bereits vor Beginn einer Schwangerschaft durch Entnahme von Zellen (Blastomeren) aus einem Embryo eine schwerwiegende genetische Erkrankung auszuschließen. So kann bei Paaren mit einem hohen Risiko für eine solche Erkrankung die Schwangerschaft mit der Sicherheit begonnen werden, daß diese Erkrankung sich nicht manifestieren wird. Unter einem hohen Risiko versteht man hierbei ein solches von 25% oder höher.

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Literatur

  1. Findlay I, Quirke P, Hall J, Rutherford A (1996) Fluorescent PCR: a new technique for PGD of sex and single-gene-defects. J Assist Reprod Genet 13: 96–103

    Article  PubMed  CAS  Google Scholar 

  2. Formigli L, Roccio C, Belotti G, Stangalini A, Coglitone MT, Formigli G (1990) Non-surgical flushing of the uterus for pre-embryo recovering: Possible clinical applications. Hum Reprod 5: 329–335

    PubMed  CAS  Google Scholar 

  3. Gimenez C, Egozcue J, Vidal F (1993) Cytogenetic sexing of mouse embryos. Hum Reprod 8: 470–474

    PubMed  CAS  Google Scholar 

  4. Handyside AH, Kontogianni EH, Hardy K, Winston RML (1990) Pregnancy from biopsied human preimplantation embryos sexed by specific DNA amplification. Nature 344: 768–770

    Article  PubMed  CAS  Google Scholar 

  5. Handyside AH, Lesko JG, Tarin JJ, Winston RLM, Hughes M (1992) Birth of a normal girl after in vitro fertilization and preimplantation diagnostic testing for cystic fibrosis. N Engl J Med 327: 905–909

    Article  PubMed  CAS  Google Scholar 

  6. Krzyminska UB, Lutjen J, O’Neill C (1990) Assessment of the viability and pregnancy poten- tial of mouse embryos biopsied at different preimplantation stages of development. Hum Reprod 5: 203–208

    PubMed  CAS  Google Scholar 

  7. Montag M, Van der Ven K, Delacretaz G, Rink K, Van der Ven H (1998) Laser-assisted micro-dissection of the zona pellucida facilitates polar body biopsy. Fertil Steril 69: 539–42

    Article  PubMed  CAS  Google Scholar 

  8. Bertina RM, Koeleman BP, Koster T, Rosendaal FR, Dirven RJ, de Ronde H, van der Velden PA, Reitsma, PH (1994) Hemostasis and Thrombosis Research Center, University Hospital, Leiden, The Netherlands. Nature May 5; 369 (6475): 64–67.

    Article  Google Scholar 

  9. Dahlbäck B (1997) Resistance to Activated Protein C as Risk Factor for Thombosis: Molecular Mechanisms, Lboratory Investigation, and Clinical Management. Seminars in Hematology, Vol 34, No 3: 217–234

    PubMed  Google Scholar 

  10. Koelemen BPC, Reitsma PH, Allaart CF, Bertina RM (1994) Activated Protein C Resistance as an Additional Risk Factor for Thrombosis in Protein C-Deficient Families. Blood Vol 84, no 4: 1031–1035

    Google Scholar 

  11. Olivieri O, Friso S, Manzato F, Guella A, Bernardi F, Lunghi B, Girelli D, Azzini M, Brocco G, Russo C, Corrocher R (1995) Resistance to activated protein C in healthy women taking oral contraceptives. British Journal of Hematology 91: 465–470

    Article  CAS  Google Scholar 

  12. Rosendaal FR, Koster T, Vandenbroucke JP, Reitsma PH (1995) High Risk of Thrombosis in Patients Homozygous for Factor V Leiden (Activated Protein C Resistance). Blood Vol 85, No 6: 1504–1508

    Google Scholar 

  13. Vandenbroucke JP, Koster T, Briet E, Reitsma PH, Bertina RM, Rosendahl FR (1994) Increased risk of venous thrombosts in oral-contraceptive users who are carriers of factor V Leiden mutation. Lancet 344: 1453–1457

    Article  Google Scholar 

  14. Williamsom D, Brown K, Luddington R, Baglin C, Baglin T (1998) Factor V Cambridge: A New Mutation (Arg 306 Thr) Associated With Resistance to Activated Protein C, Blood Vol 91, No 4: 1140–1144

    Google Scholar 

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Authors
  1. M. Ludwig
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  2. K. Diedrich
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Editor information

Editors and Affiliations

  1. Frauenklinik — Klinikum St. Marien, Universität Erlangen-Nürnberg, 92224, Amberg, Germany

    Dietrich Berg

  2. Klinik für Frauenheilkunde und Geburtshilfe, Medizinische Universität zu Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany

    Klaus Diedrich

  3. Gynäkologische Abteilung, Albert-Schweitzer- Krankenhaus, Sturmbäume 8–10, 37154, Northeim, Germany

    Rüdiger Rauskolb

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© 2000 Springer-Verlag Berlin Heidelberg

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Ludwig, M., Diedrich, K. (2000). Klinische Einsatzmöglichkeiten der Molekularbiologie. In: Berg, D., Diedrich, K., Rauskolb, R. (eds) 52. Kongreß der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59688-9_37

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  • DOI: https://doi.org/10.1007/978-3-642-59688-9_37

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64085-8

  • Online ISBN: 978-3-642-59688-9

  • eBook Packages: Springer Book Archive

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