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Antiretrovirale Therapie (ART) mit nukleosidalen reverse Transkriptaseinhibitoren (NRT)

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HIV-Infekt

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Zusammenfassung

Mittlerweile stehen 6 nukleosidale reverse Transkriptaseinhibitoren als Bausteine für die anti- retrovirale Kombinationstherapie zur Verfügung (Tabelle 1). Alle Nukleosidanaloga stellen leicht veränderte Nukleotide dar. Sie unterscheiden sich jeweils nur durch einzelne Atome an ganz bestimmten Stellen des Moleküls. Die Nukleosidanaloga werden dann anstelle der natürlichen Nukleotide als ≫falsche≪ Bausteine in die DNA-Kette eingebaut and die DNA-Kette kann somit nicht mehr verldngert werden and es kommt zum Kettenabbruch. Autßerdem findet dabei eine Hemmung der reversen Transkriptase statt. Tabelle 1 fatßt die derzeit verfugbaren Nukleosidanaloga hinsichtlich Handelsname, Nebenwirkungen, Dosierung, Einnahmeabstand and Einnahmehinweise zusammen.

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Authors
  1. J. K. Rockstroh
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Editors and Affiliations

  1. Klinik für Dermatologie, Allergologie und Venerologie, Ruhr-Universität Bochum, Gudrunstraße 56, Deutschland

    Norbert H. Brockmeyer , Klaus Hoffmann , G. Reimann , Markus Stücker  & Peter Altmeyer , , ,  & 

  2. Medizinische Klinik III, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Deutschland

    R. Brodt

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© 2000 Springer-Verlag Berlin Heidelberg

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Rockstroh, J.K. (2000). Antiretrovirale Therapie (ART) mit nukleosidalen reverse Transkriptaseinhibitoren (NRT). In: Brockmeyer, N.H., Hoffmann, K., Reimann, G., Stücker, M., Altmeyer, P., Brodt, R. (eds) HIV-Infekt. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59683-4_35

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  • DOI: https://doi.org/10.1007/978-3-642-59683-4_35

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64082-7

  • Online ISBN: 978-3-642-59683-4

  • eBook Packages: Springer Book Archive

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