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Live Attenuated AIDS Virus Vaccines: Where to go from Here?

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HIV-Infekt

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Abstract

Human immunodeficiency virus type 1 (HIV-1) infections continue to escalate world-wide. Still, no safe and effective AIDS vaccine has been found, even though a number of vaccine strategies, including live attenuated lentiviruses, have been evaluated in primate models. Live attenuated virus vaccines have played important roles in preventing a number of viral illnesses, such as smallpox, poliomyelitis, measles, and chicken pox [23]. These vaccines induce broad-based, long-lived immune responses. Live attenuated vaccine viruses cause acute infections in the vaccine recipients and induce both specific antiviral anti-bodies and T-cell immunity that limit further virus spread and ultimately clear the vaccine virus infection.

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References

  1. Baba TW, Jeong YS, Penninck D, Bronson R, Greene MF, Ruprecht RM (1995) Pathogenicity of live, attenuated SIV after mucosal infection of neonatal macaques. Science 267: 1820–1825

    Article  PubMed  CAS  Google Scholar 

  2. Baba et al. (1995) Technical comments. Attenuated retrovirus vaccines and AIDS. Science 270: 1220–1221

    CAS  Google Scholar 

  3. Baba et al. (1999) Live attenuated, multiply deleted simian immunodeficiency virus causes AIDS in infant and adult macaques. Nat Med 5: 194–203

    Article  PubMed  CAS  Google Scholar 

  4. Cohen J (1994) At conference, hope for success is further attenuated. Science 266: 1154

    Article  PubMed  CAS  Google Scholar 

  5. Cohen J (i997) Weakened SIV vaccine still kills (news). Science 278:24–25

    Google Scholar 

  6. Daniel MD, Kirchhoff, Czajak SC, Sehgal PK, Desrosiers RC (1992) Protective effects of a live attenuated SIV vaccine with a deletion in the nef gene. Science 258: 1938–1941

    Article  PubMed  CAS  Google Scholar 

  7. Deacon et al. (1995) Genomic structure of an attenuated quasi species of HIV-1 from a blood transfusion donor and recipients. Science 270: 988–991

    Article  PubMed  CAS  Google Scholar 

  8. Denesvre C et al. (1995) Highly attenuated SIVmac142 is immunogenic but does not protect against SIVmac251 challenge. AIDS Res Hum Retroviruses 11: 1397–1406

    Article  PubMed  CAS  Google Scholar 

  9. Desrosiers R, Daniel M, Lifson J, Arthur LO (1995) Infection of chimpanzees with attenuated HIV-1 deletion mutants. In: Girard M, Dodet B eds. 10e Colloque des Cents Gardes, Retroviruses of human AIDS and related animal diseases. Amsterdam: Elsevier; pp 197–200

    Google Scholar 

  10. Editorial (1997) Live-attenuated AIDS vaccines: new safety findings reported. IAVI Report 2: 1–3

    Google Scholar 

  11. Farthing CF, Sullivan JL (1998) SIV vaccine for AIDS. Science 279: 14–15

    Article  PubMed  CAS  Google Scholar 

  12. Gibbs JS, Regier DA, Desrosiers RC (1994) Construction and in vitro properties of SIVmac mutants with deletions in ≫nonessential≪ genes. AIDS Res Hum Retroviruses 10: 607–616

    Article  PubMed  CAS  Google Scholar 

  13. Gibbs JS, Regier DA, Desrosiers RC (1994) Construction and in vitro properties of HIV-1 mutants with deletions in ≫nonessential≪ genes. AIDS Res Hum Retroviruses 10: 343–350

    Article  PubMed  CAS  Google Scholar 

  14. Greenough TC, Sullivan JL, Desrosier RC (1999) Declining CD4 T-cell counts in a person infected with nef-deleted HIV-1. N Engl J Med 340: 236–237

    Article  PubMed  CAS  Google Scholar 

  15. Havlir DV, Barnes PF (1999) Tuberculosis in patients with human immunodeficiency virus infection. Curr Concepts 340: 367–373

    CAS  Google Scholar 

  16. Johnson RP et al. (1999) Highly attenuated vaccine strains of simian immunodeficiency virus protect against vaginal challenge: inverse relationship of degree of protection with level of attenuation. J Virol 73: 4952–4961

    PubMed  CAS  Google Scholar 

  17. Kestler HW 3rd, Ringler DJ, Mori K, Panicali DL, Sehgal PK, Daniel MD, Desrosiers RC (1991) Importance of the nef gene for maintenance of high virus loads and for development of AIDS. Cell 65:651–662

    Article  PubMed  CAS  Google Scholar 

  18. Kirchhoff F, Greenough TC, Brettler DB, Sullivan JL, Desrosiers RC (1995) Absence of intact nef sequences in a long term survivor with nonprogressive HIV-1 infection. N Engl J Med 332: 228–232

    Article  PubMed  CAS  Google Scholar 

  19. Learmont J et al. (1992) Long-term symptomless HIV-i infection in recipients of blood products from a single donor. Lancet 340: 863–867

    Article  PubMed  CAS  Google Scholar 

  20. Learmont J et al. (1999) Immunologic and virologie status after 14 to 18 years of infection with an attenuated strain of HIV-1. N Engl J Med 234: 1715–1722.

    Article  Google Scholar 

  21. Lohman BL et al. (1994) A partially attenuated simian immunodeficiency virus induces host immunity that correlates with resistance to pathogenic virus challenge. J Virol 68: 7021–7029

    PubMed  CAS  Google Scholar 

  22. Mariani R et al. (1996) High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection. J Virol 70: 7752–7764

    PubMed  CAS  Google Scholar 

  23. Plotkin SA, Orenstein WA eds. (1999) Vaccines. Philadelphia: W.B. Saunders Company

    Google Scholar 

  24. Rey-Cuillé A, Berthier J-L, Bomsel-Demontoy C, Chaduc Y, Montagnier L, Hovanessian AG, Chakrabarti LK (1998) Simian immunodeficiency virus replicates to high levels in sooty mangabeys without inducing disease. J Virol 72: 3872–3886

    PubMed  Google Scholar 

  25. Ruprecht RM (1999) Live attenuated AIDS viruses as vaccines: Promise or peril? Immunol Rev (in press)

    Google Scholar 

  26. Ruprecht RM, Baba TW, Rasmussen R, Hu Y, Sharma PL (1996) Murine and simian retrovirus models: the threshold hypothesis. AIDS 10 (Suppl A): S33–S40

    Article  PubMed  Google Scholar 

  27. Ruprecht RM et al. (1996) Live attenuated HIV as a vaccine for AIDS: pros and cons. Seminars in Virology 7: 147–155

    Article  Google Scholar 

  28. Sabin AB (1985) Oral poliovirus vaccine: history of its development and use and current challenge to eliminate poliomyelitis from the world. J Infect Dis 151: 420–436

    Article  PubMed  CAS  Google Scholar 

  29. Ten Haaft P, Verstrepen B, Überla K, Rosenwirth B, Heeney J (1998) A pathogenic threshold of virus load defined in simian immunodeficiency virus- or simian-human immunodeficiency virus-infected macaques. J Virol 72: 10281–10285

    PubMed  Google Scholar 

  30. Wyand MS, Manson KH, Garcia-Moll, M, Montefiori D, Desrosiers RC (1996) Vaccine protection by a triple deletion mutant of simian immunodeficiency virus. J Virol 70: 3724–3733

    PubMed  CAS  Google Scholar 

  31. Wyand MS, Manson KH, Lackner A, Desrosiers RC (1997) Resistance of neonatal monkeys to live attenuated vaccine strains of simian immunodeficiency virus. Nat Med 3: 32–361

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. R. M. Ruprecht
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  2. V. Liska
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  3. R. Hofmann-Lehmann
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  4. A. H. Khimani
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  5. R. A. Rasmussen
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  6. J. Vlasak
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  7. H. M. McClure
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Editor information

Editors and Affiliations

  1. Klinik für Dermatologie, Allergologie und Venerologie, Ruhr-Universität Bochum, Gudrunstraße 56, Deutschland

    Norbert H. Brockmeyer , Klaus Hoffmann , G. Reimann , Markus Stücker  & Peter Altmeyer , , ,  & 

  2. Medizinische Klinik III, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Deutschland

    R. Brodt

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© 2000 Springer-Verlag Berlin Heidelberg

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Ruprecht, R.M. et al. (2000). Live Attenuated AIDS Virus Vaccines: Where to go from Here?. In: Brockmeyer, N.H., Hoffmann, K., Reimann, G., Stücker, M., Altmeyer, P., Brodt, R. (eds) HIV-Infekt. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59683-4_3

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  • DOI: https://doi.org/10.1007/978-3-642-59683-4_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64082-7

  • Online ISBN: 978-3-642-59683-4

  • eBook Packages: Springer Book Archive

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