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Homozygote CCR5Δ32 bp Deletion bei zwei HIV-1 infizierten Patienten

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HIV-Infekt

Zusammenfassung

Die Deletion (Δ) von 32 bp im CCR5 (Chemokin Rezeptor 5) führt zu einer Nicht-Expression dieses G-Proteins auf der Lymphozytenplasma-Membran und damit zum Fehlen des Corezeptors den makrophagotrope HIV zum Zelleintritt benötigen [1–5]. Lymphotrope Viren, die häufig auch Synzytien induzieren, gelangen zum Zelleintritt unter Umgehen des CCR5, da sie neben dem CD4 Rezeptor den CXCR-4 (Chemokin Rezeptor 4) benutzen [6]. Mehrere Arbeiten haben beschrieben, daß das homozygote mutante Allel des CCR5 vor HIV Infektion schützt [7], während zeitgleich weitere Berichte belegten, daß auch die Individuen mit der homozygoten Deletion mit HIV infiziert werden können [8–11]. Wir berichten über 2 weitere Patienten, die trotz der genetischen Deletion des CCR5 mit aggressiv wachsenden, lymphotropen HIV-1B Stämmen infiziert sind und deren V3-loop Kronenmotif sehr seltene Varianten enthält.

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Authors
  1. W. Siffert
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  2. N. H. Brockmeyer
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  3. S. Staszewski
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  4. L. Gürtler
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Editors and Affiliations

  1. Klinik für Dermatologie, Allergologie und Venerologie, Ruhr-Universität Bochum, Gudrunstraße 56, Deutschland

    Norbert H. Brockmeyer , Klaus Hoffmann , G. Reimann , Markus Stücker  & Peter Altmeyer , , ,  & 

  2. Medizinische Klinik III, Universitätsklinikum Frankfurt, Theodor-Stern-Kai 7, 60590, Frankfurt, Deutschland

    R. Brodt

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© 2000 Springer-Verlag Berlin Heidelberg

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Siffert, W., Brockmeyer, N.H., Staszewski, S., Gürtler, L. (2000). Homozygote CCR5Δ32 bp Deletion bei zwei HIV-1 infizierten Patienten. In: Brockmeyer, N.H., Hoffmann, K., Reimann, G., Stücker, M., Altmeyer, P., Brodt, R. (eds) HIV-Infekt. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59683-4_15

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  • DOI: https://doi.org/10.1007/978-3-642-59683-4_15

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64082-7

  • Online ISBN: 978-3-642-59683-4

  • eBook Packages: Springer Book Archive

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