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The Role of Bacterial DNA in Autoantibody Induction

  • Chapter
Immunobiology of Bacterial CpG-DNA

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 247))

Abstract

Antibodies to DNA (anti-DNA) are prototypic autoantibodies that occur prominently in systemic lupus erythematosus (SLE). These antibodies target sites on single- as well as double-stranded DNA and serve as markers of diagnostic and prognostic significance. In addition, anti-DNA play a direct role in disease pathogenesis, provoking renal injury through immune-complex deposition (Pisetsky 1992). Because of their close association with SLE, anti-DNA have been considered virtually synonymous with autoimmunity and key to understanding disease mechanisms (Eilat and Anderson 1994; Radic and Weigert 1994).

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Authors and Affiliations

  1. VA Medical Center, Box 151G, Room E-1008, 508 Fulton Street, Durham, NC, 27705, USA

    D. S. Pisetsky

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  1. D. S. Pisetsky
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Editors and Affiliations

  1. Institut für Medizinische Mikrobiologie, Immunologie und Hygiene der Technischen Universität München, Trogerstr. 9, D-81675, München, Germany

    Hermann Wagner Ph.D.

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© 2000 Springer-Verlag Berlin Heidelberg

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Pisetsky, D.S. (2000). The Role of Bacterial DNA in Autoantibody Induction. In: Wagner, H. (eds) Immunobiology of Bacterial CpG-DNA. Current Topics in Microbiology and Immunology, vol 247. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59672-8_10

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  • DOI: https://doi.org/10.1007/978-3-642-59672-8_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64077-3

  • Online ISBN: 978-3-642-59672-8

  • eBook Packages: Springer Book Archive

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