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Neuro-Immune Interactions in Neurologic and Psychiatric Disorders pp 57–72Cite as

Mechanistic and Metaphorical Connections Between NF-KB and the Secreted Alzheimer’s β-Amyloid Precursor Protein

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Part of the book series: Research and Perspectives in Neurosciences ((NEUROSCIENCE))

Summary

NF- K B is a designation originally referring to a DNA-binding activity that bound the K B enhancer of immunoglobulin K light chain and stimulated transcription. The proteins responsible for this activity have since been cloned and studied extensively by immunologists, structural biochemists, and cell biologists. Only recently have neurobiologists turned their attention to NF- K B to study its role in the nervous system. Predictable roles for NF- K B in the regulation of glial cytokines have been confirmed. Less obvious roles have been suggested for NF- K B in processes peculiar to neurons, such as synaptic plasticity. Its participation in inflammation and its induction by toxic stimuli such as tumor necrosis factor (TNF) led to the common interpretation of NF- K B as a pathogenic factor. An alternative interpretation, that NF- K B is involved in compensatory responses to pathogens, was supported by our demonstration that some neuroprotective factors can activate NF- K B or a similar activity in neurons. At least one of these factors - secreted β-amyloid precursor protein (sAPP) - can also induce NF- K B and inflammatory reactions in microglia, the phagocytic inflammatory cells of the central nervous system. This fact makes sAPP a factor with both beneficial and harmful effects on neuronal health. This “double-edged” phenomenon and the factors that influence the balance of sAPP’s effects are discussed herein.

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  1. S. W. Barger
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  2. X. Mao
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  3. A. M. Moerman
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  4. A. Ranganathan
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Editors and Affiliations

  1. Biology Division, California Institute of Technology, Pasadena, CA, 91125, USA

    Paul Patterson

  2. Centre Paul Broca, INSERM U159, 2ter, Rue d’Alesia, 75014, Paris, France

    Claude Kordon

  3. Fondation IPSEN, 24, Rue Erlanger, 75781, Paris Cedex 16, France

    Yves Christen

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© 2000 Springer-Verlag Berlin Heidelberg

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Barger, S.W., Mao, X., Moerman, A.M., Ranganathan, A. (2000). Mechanistic and Metaphorical Connections Between NF-KB and the Secreted Alzheimer’s β-Amyloid Precursor Protein. In: Patterson, P., Kordon, C., Christen, Y. (eds) Neuro-Immune Interactions in Neurologic and Psychiatric Disorders. Research and Perspectives in Neurosciences. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59643-8_6

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  • DOI: https://doi.org/10.1007/978-3-642-59643-8_6

  • Publisher Name: Springer, Berlin, Heidelberg

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