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Clinical Imaging in Non-Pulmonary Tuberculosis pp 177–188Cite as

Radionuclides in the Evaluation of Extra-Pulmonary Tuberculosis

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Abstract

It is widely acknowledged that nuclear medicine procedures are generally more sensitive than morphological imaging techniques for the localisation of sites of infection. With tuberculosis (TB), radionuclide imaging offers an indicator, of both the presence and the extent of active disease, which has been proven to be effective in the evaluation of suspected extra-pulmonary localisation, potentially revealing early abnormalities at unsuspected sites of sub-clinical disease [1–4]. It should be emphasised, however, that usually these techniques suffer a low specificity. In particular, multi-focal presentation can be confused with metastatic disease unless the scan appearances are interpreted in conjunction with a careful consideration of the clinical history.

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References

  1. Moody EB, Glassmar SB, Hansen AV, Lawrence SK, Delbeke D (1992) Nuclear medicine case of the day. Case 1: miliary tuberculosis. Am J Roentgenol 158: 1382–1386

    CAS  Google Scholar 

  2. Yang S-O, Lee YI, Chung DH, Lee MC, Koh C-S, Choi BI, Im J-G, Park JH, Han MC, Kim C-W (1992) Detection of extrapulmonary tuberculosis with gallium-67 scan and computed tomography. J Nucl Med 33: 2118–2123

    PubMed  CAS  Google Scholar 

  3. Kao C-H, Wang S-J, Liao S-Q, Lin W-Y, Hsu C-Y (1993) Usefulness of gallium-67-citrate scans in patients with acute disseminated tuberculosis and comparison with chest X-rays. J Nucl Med 34: 1918–1921

    PubMed  CAS  Google Scholar 

  4. Abdel-Daye HM, Naddaf S, Aziz M, Mina B, Turoglu T, Akisik MF, Omar WS, Di Fabrizio L, LaBombardi V, Kempf JS (1997) Sites of tuberculous involvement in patients with AIDS. Autopsy findings and evaluation of gallium imaging. Clin Nucl Med 22: 310–314

    Article  Google Scholar 

  5. McAfee JG (1996) Editorial comment. In: The year book of nuclear medicine. Mosby, London, pp 94–95

    Google Scholar 

  6. Sarkar SD, Ravikrishman KP, Woodbury DH, Carson JJ, Daley K (1979) Gallium-67 citrate scanning-a new adjunct in the detection and follow-up of extrapulmonary tuberculosis: concise communication. J Nucl Med 20: 833–836

    PubMed  CAS  Google Scholar 

  7. Bekerman C, Bitran J (1988) Gallium-67 scanning in the clinical evaluation of human immunodeficiency virus infection: indications and limitations. Semin Nucl Med 18: 273–286

    Article  PubMed  CAS  Google Scholar 

  8. Lisbona R, Derbekyan V, Novales-Diaz J, Veksler A (1993) Gallium-67 scintigraphy in tuberculous and non-tuber-culous infectious spondylitis. J Nucl Med 34: 853–859

    PubMed  CAS  Google Scholar 

  9. Tsan M-F (1985) Mechanism of gallium-67 accumulation in inflammatory lesions. J Nucl Med 26: 88–92

    PubMed  CAS  Google Scholar 

  10. Sarkar SD, Ravikrishman KP (1978) Gallium-67 citrate scanning in extra-pulmonary tuberculosis. Nucl Med 19: 734

    Google Scholar 

  11. Kao P-F, Tzen K-Y, Chou Y-H, Lu S-Y, You D-L (1996) Accumulation of Ga-67 citrate in a tuberculous splenic abscess: report of a rare case. Clin Nucl Med 21: 49–52

    Article  PubMed  CAS  Google Scholar 

  12. Ohta H, Fukuyama T, Sakamoto M, Kombuchi T, Shintaku M (1995) Liver tuberculoma detected by Ga-67 imaging. Clin Nucl Med 7: 577

    Google Scholar 

  13. Young T-H, Hsieh J-P, Chao Y-C, Hsu C-T, Ho-Tom, Tang H-S (1996) Esophageal tuberculosis with supraclavicular lymph node involvement demonstrated by Ga-67 imaging. Clin Nucl Med 21: 344

    Article  PubMed  CAS  Google Scholar 

  14. Brophey M, Lamki L, Barron B, Shah S (1995) Prominent small bowel Ga-67 uptake associated with yersinial and tuberculous enterocolitis. Clin Nucl Med 20: 107–110

    Article  PubMed  CAS  Google Scholar 

  15. Goldfarb CR, Ongseng F, Finestone H, Colp C, Parmett SR (1995) Ga-67 scintigraphic appearances of tuberculosis in the “new” tuberculosis. J Nucl Med 36: 23

    Google Scholar 

  16. Hardoff R, Efrat M, Gips A (1995) Multifocal osteoarticular tuberculosis resembling skeletal metastatic disease. Evaluation with Tc-99m MDP and Ga-67 citrate. Clin Nucl Med 20: 279–281

    Article  PubMed  CAS  Google Scholar 

  17. Santin M, Podzamczer D, Ricart I, Mascaro J, Ramon JM, Dominguez A, Rufi G, Gudiol F (1995) Utility of the gal-lium-67 citrate scan for the early diagnosis of tuberculosis in patients infected with the human immunodeficiency virus. Clin Infect Dis 20: 652–656

    Article  PubMed  CAS  Google Scholar 

  18. Lee VW, Cooley TP, Fuller JD, Ward RJ, Farher HW (1994) Pulmonary mycobacterial infections in AIDS: characteristic pattern of thallium and gallium scan mismatch. Radiology 193: 389–392

    PubMed  CAS  Google Scholar 

  19. Sfakianalkis GN, Al-Sheikh W, Head A (1982) Comparison of scintigraphy with In-111 leukocytes and Ga–67 in the diagnosis of occult sepsis. J Nucl Med 23: 618

    Google Scholar 

  20. Palestro CJ, Swyer AJ, Kim CK, Goldsmith SJ (1991). Relative efficacy of In-111 leukocyte and Ga-67 imaging in HIV (+) patients. J Nucl Med 32: 1003

    Google Scholar 

  21. Pettengell K, Garb M, Houlder A, Becker P, Simjee A (1990) Radionuclide scintigraphy in tuberculous enteritis. Gastrointest Radiol 15: 148–150

    Article  PubMed  CAS  Google Scholar 

  22. Fanning A, Dierich H, Lentle B (1974) Bone scanning with 99mTc polyphosphate in tuberculous osteomyelitis. Tubercle 55: 227–230

    Article  PubMed  CAS  Google Scholar 

  23. Abdelwahab IF, Kenan S, Hermann G, Lewis M, Klein M, Rabinowitz JG (1991) Atypical skeletal tuberculosis mi-micking neoplasm. Br J Radiol 64: 551–555

    Article  PubMed  CAS  Google Scholar 

  24. Pui MH, Chin-Sang HR, Rubenstein JD (1986) False-normal bone imaging in spinal tuberculosis. Clin Nucl Med 11: 245–248

    Article  PubMed  CAS  Google Scholar 

  25. Muradali D, Gold WL, Vellend H, Becker E (1993) Multi-focal osteoarticular tuberculosis: report of four cases and review of management. Clin Infect Dis 17: 204–208

    Article  PubMed  CAS  Google Scholar 

  26. Nocera RM, Sayle B, Rogers C, Wilkey D (1983) Tc-99m MDP Indium-111 chloride scintigraphy in skeletal tuberculosis. Clin Nucl Med 8: 418–420

    Article  PubMed  CAS  Google Scholar 

  27. Rust RJ, Park HM, Robb JA (1981) Skeletal scintigraphy in miliary tuberculosis: photopenia after treatment. Am J Radiol 137: 877–879

    CAS  Google Scholar 

  28. Tamgac F, Baillet G,Alper E, Delporte MP, Moretti JL (1995) Extraskeletal accumulation of Tc-99m HMDP in a tuberculous cold abscess. Clin Nucl Med 20: 1092

    Article  PubMed  CAS  Google Scholar 

  29. Greenspan A, Stadainik RC (1995) Increased uptake around the hip joint. Semin Nucl Med 25: 283–286

    Article  PubMed  CAS  Google Scholar 

  30. Sciuk J, Brandau W, Vollet B, Stucker R, Erlemann R, Bartenstein P, Peters PE, Schober O (1991) Comparison of technetium-99m polyclonal human immunoglobulin and technetium 99m monoclonal antibodies for imaging chronic osteomyelitis. First clinical results. Eur J Nucl Med 18: 401–407

    Article  PubMed  CAS  Google Scholar 

  31. Sharif HS, Aideyan OA, Clark DC, Madkour MM, Aabed MY, Mattsson TA, Al-Deeb SM, Moutaery KR (1989) Brucellar and tuberculous spondylitis: comparative imaging features. Radiology 171: 419–425

    PubMed  CAS  Google Scholar 

  32. Kimmel DJ, Klingensmith WC III (1980) Unusual scintigraphic appearance of osteomyelitis secondary to atypical myobacterium. Clin Nucl Med 5: 189–190

    Article  PubMed  CAS  Google Scholar 

  33. Ohta H, Ichii H, Arimoto A, Ukikusa M, Awane H (1998) Tc-99m sestamibi uptake in tuberculosis of the breast. Clin Nucl Med 23: 106–108

    Article  PubMed  CAS  Google Scholar 

  34. Kobayashi H, Kotoura Y, Hosono M, Tsuboyama T, Sakahara H, Konishi J (1995) Solitary muscular involvement by tuberculosis: CT, MRI and scintigraphic features. Comput Med Imaging Graph 19: 237–240

    Article  PubMed  CAS  Google Scholar 

  35. Somawardhana CW, Lambrecht RM (1989) [Iodine-124]-2- iodoisonicotinic acid hydrazide: a potential radiotracer for tuberculoma. J Nucl Med 30:1756

    Google Scholar 

  36. Somawardhana CW, Sajjad M, Amartey JK, Lambrecht RM (1991) Synthesis of 2-[123I and 124I]-iodoisonicotinic acid hydrazide: potential radiotracers for tuberculosis. Appl Radiat Isot 42: 215–220

    Article  CAS  Google Scholar 

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Authors
  1. D. Hamilton
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  2. J. Al Nabulsi
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© 2000 Springer-Verlag Berlin Heidelberg

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Hamilton, D., Al Nabulsi, J. (2000). Radionuclides in the Evaluation of Extra-Pulmonary Tuberculosis. In: Clinical Imaging in Non-Pulmonary Tuberculosis. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59635-3_11

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  • DOI: https://doi.org/10.1007/978-3-642-59635-3_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64061-2

  • Online ISBN: 978-3-642-59635-3

  • eBook Packages: Springer Book Archive

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