Abstract
An endoluminal surface coil: Esophageal cancer was studied by high resolution magnetic resonance imaging (MRI) to determine the histopathologic basis for signal intensity in these lesions and to determine the potential of this modality for evaluating the depth of cancer invasion. In a basic study, 14 tumors were examined with a 1.5-T superconductive MR system using a surface coil. The esophageal wall could be differentiated into four layers on the T1-weighted images and seven layers on the T2-weighted images. The signal intensity of the tumor varied from low to intermediate on the T1- and T2-weighted images. The submucosal layer is important in evaluating cancer invasion on the T2-weighted images. In a clinical study, 30 patients with esophageal cancer were examined with a 1.5-T superconductive MR system using an endoluminal surface coil. In terms of depth of cancer invasion, the accuracy rate of MRI using the endoluminal surface coil was 83%. In conclusion, MRI with an endoluminal surface coil will be a useful examination for esophageal cancer in the future.
Antibody-coated magnetite particles: A highly specific and effective MRI contrast agent was prepared by coating superparamagnetite particles with monoclonal antibodies (MAbs) directed against epidermal growth factor receptors (EGFRs), which are overexpressed in esophageal squamous cell carcinoma. The agent was shown to have EGFR-specific MRI contrast capacity in vivo in athymic rats bearing TE8 or H69 tumors Immunospecific MRI using magnetite particles coated with MAbs against EGFR seems to be useful in the diagnosis of squamous cell carcinoma of the esophagus.
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References
Holscher AH, Dittler HJ, Siewert JR (1994) Staging of squamous esophageal cancer: accuracy and value. World J Surg 18: 312–320
Imai Y, Kressel HY, Saul SH, Chao PH et al (1990) Colorectal tumors: an in vitro study of high-resolution MR imaging. Radiology 177: 695–701
Japanese Society for Esophageal Disease. Guide lines for the clinical and pathologic studies on carcinoma of the esophagus, 8th edn
Schnall MD, Imai Y, Tomaszewski J et al (1991) Prostate cancer: local staging with endorectal surface coil MR imaging. Radiology 178: 797–802
Corn BW, Lanciano RM, Rosenblum N et al (1995) Improved treatment planning for the Syed-Neblett template using endorectal coil magnetic resonance and intraoperative (laparotomy/laparoscopy) guidance: a new integrated technique for hysterectomized women with vaginal tumors. Gynecol Oncol 56: 255–261
Ozawa S, Ueda M, Ando N et al (1987) High incidence of EGF receptor hyperproduction in esophageal squamous cell carcinomas. Int J Cancer 39: 333–337
Ozawa S, Ueda M, Ando N et al (1989) Prognostic significance of epidermal growth factor receptor in esophageal squamous cell carcinomas. Cancer 63: 2169–2173
Vogl TJ, Hammerstingl R, Schwarz W et al (1996) Magnetic resonance imaging of focal liver lesions. Comparison of the superparamagnetic iron oxide resovist versus gadolinium-DTPA in the same patient. Invest Radiol 31: 696–708
Cerdan S, Lotscher H, Kunnecke B et al (1989) Monoclonal antibody-coated magnetite particles as contrast agents in magnetic resonance of tumors. Magn Reson Med 12: 151–163
Weissleder R, Elizondo G, Wittenberg J et al (1990) Ultrasmall superparamagnetic iron oxide: characterization of a new class of contrast agents for MR imaging. Radiology 175: 489–493
Renkin E, Curry F (1982) Endothelial permeability: pathways and modulations. Ann N Y Acad Sci 401: 248–259
Tiefenauer LX, Kuhne G, Andres RY (1993) Antibody magnetite nanoparticles: in vitro characterization of a potential tumor-specific contrast agent for magnetic resonance imaging. Bioconjug Chem 4: 347–352
Renshaw PF, Owen CS, Evans AE et al (1986) Immunospecific NMR contrast agents. Magn Reson Imaging 4: 351–357
Cohen B, Arai SF, Brain JD (1979) Smoking impairs long-term dust clearance from the lung. Science 204: 514–516
Ozawa S, Imai Y, Ando N et al (1996) High-resolution magnetic resonance imaging of esophageal cancer using an endoluminal surface coil. In: Peracchia A et al (eds) Recent advances in diseases of the esophagus. Monduzzi, Bologna, pp 165–175
Suwa T, Ozawa S, Ueda M et al (1997) Magnetic resonance imaging of squamous cell carcinoma using magnetite particle coated with anti-epidermal growth factor receptor antibody. Int J Cancer 75: 626–634
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© 2000 Springer-Verlag Berlin Heidelberg
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Ozawa, S., Imai, Y., Suwa, T., Kitajima, M. (2000). What’s New in Imaging?. In: Lange, J., Siewert, J.R. (eds) Esophageal Carcinoma. Recent Results in Cancer Research, vol 155. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59600-1_7
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DOI: https://doi.org/10.1007/978-3-642-59600-1_7
Publisher Name: Springer, Berlin, Heidelberg
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