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Hematopoietic Cell Transplantation: The First 50 Years and a Glimpse of the Future

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Transplantation in Hematology and Oncology

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Abstract

In the early part of the twentieth century, through the work of Alexis Carrel and others, it was quite well established that allografts of organs such as skin or kidney would function for a time but after one or two weeks the graft would be lost. In the 1940s Medawar and colleagues established clearly the immunological basis of allograft rejection. That allografts might not always be incompatible was suggested by Owen who found that “freemartin” bovine dizygotic twins had a mixture of red blood types from each partner. It remained for Billingham, Brent and Medawar to show that donor specific tolerance could be induced by injection of donor cells into newborn mice. The exciting early days of transplantation immunology are described in detail in the 1960 monograph of Woodruff [1], written near the time of action, and the 1997 monograph of Brent [2], written with the clarity made possible by the passage of three decades.

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Authors
  1. E. D. Thomas
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Editors and Affiliations

  1. Department of Internal Medicine Hematology/Oncology, University of Muenster, Albert-Schweitzer-Straße 33, 48129, Muenster, Germany

    W. E. Berdel (Prof. Dr. med.), Th. Büchner (Prof. Dr. med.), J. Kienast  & J. Van De Loo (Prof. Dr. med.) (Prof. Dr. med.),  (Prof. Dr. med.),  &  (Prof. Dr. med.)

  2. Department of Pediatrics, University of Münster, Albert-Schweitzer-Straße 33, 48129, Muenster, Germany

    H. Jürgens (Prof. Dr. med.), J. Ritter (Prof. Dr. med.) & J. Vormoor (Dr. med.) (Prof. Dr. med.),  (Prof. Dr. med.) &  (Dr. med.)

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© 2000 Springer-Verlag Berlin Heidelberg

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Thomas, E.D. (2000). Hematopoietic Cell Transplantation: The First 50 Years and a Glimpse of the Future. In: Berdel, W.E., et al. Transplantation in Hematology and Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59592-9_1

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  • DOI: https://doi.org/10.1007/978-3-642-59592-9_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64041-4

  • Online ISBN: 978-3-642-59592-9

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