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Anomalien des Urogenitalsystems im Rahmen multipler Fehlbildungen

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Genetik von Krankheiten des Urogenitalsystems

Zusammenfassung

Morphologische und funktionelle Störungen des menschlichen Urogenitaltrakts sind besonders häufig mit Minor- und Majoranomalien anderer Entwicklungsfelder verknüpft. Beinah synchron laufen während der Embryonalentwicklung ähnliche epithelial-mesenchymale Interaktionen auch in anderen Organsystemen ab, die dann in gleicher Weise störanfällig sind. Auch das für die Entwicklung des Urogenitaltraktes wichtige Wechselspiel von Testosteron, Anti-Müller-Hormon und Östrogenen beschränkt sich offenbar nicht nur auf das urogenitale Entwicklungsfeld. Schließlich muß bedacht werden, daß es sich beim Harntrakt um ein exkretorisches Organsystem handelt, bei dem auch Funktionsstörungen der Harnproduktion und -ausscheidung Einfluß auf den Gesamtorganismus nehmen können, wie die PotterSequenz und Prune-belly-Sequenz jeweils eindrucksvoll belegen.

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Authors
  1. J. Mücke
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  2. J. Kunze
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Editors and Affiliations

  1. Klinik und Poliklinik für Urologie und Kinderurologie, der Universität des Saarlandes, 66421, Homburg/Saar, Deutschland

    Bernd Wullich Priv. Doz. Dr. med.

  2. Leiter des Instituts für Humangenetik, der Universität des Saarlandes, 66421, Homburg/Saar, Deutschland

    Klaus Dieter Zang Prof. Dr. med.

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© 2000 Springer-Verlag Berlin Heidelberg

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Mücke, J., Kunze, J. (2000). Anomalien des Urogenitalsystems im Rahmen multipler Fehlbildungen. In: Wullich, B., Zang, K.D. (eds) Genetik von Krankheiten des Urogenitalsystems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59589-9_6

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  • DOI: https://doi.org/10.1007/978-3-642-59589-9_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-64039-1

  • Online ISBN: 978-3-642-59589-9

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