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Biochemical Sites of Insecticide Action and Resistance pp 255–267Cite as

Cytochrome P450 Monooxygenases and Insecticide Resistance: Lessons from CYP6D1

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Abstract

The cytochrome P450-dependent monooxygenases (monooxygenases) are a vital biochemical system because they metabolize xenobiotics such as drugs, pesticides and plant toxins, and because they regulate the titers of endogenous compounds such as hormones, fatty acids and steroids. Cytochrome P450 (P450) is a hemoprotein which acts as the terminal oxidase in monooxygenase systems, and there are multiple P450 isoforms in eukaryotic species. Monooxygenases are remarkable in that they can oxidize widely diverse substrates and are capable of producing a bewildering array of reactions (Kulkarni and Hodgson 1980; Rendic and Di Carlo 1997; Mansuy 1998).

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  1. Department of Entomology, Comstock Hall, Cornell University, Ithaca, NY, 14853-0901, USA

    Jeffrey G. Scott

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  1. Department of Entomology Agricultural Research Organization, The Volcani Center, Bet Dagan, 50250, Isarael

    Isaac Ishaaya

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Scott, J.G. (2001). Cytochrome P450 Monooxygenases and Insecticide Resistance: Lessons from CYP6D1 . In: Ishaaya, I. (eds) Biochemical Sites of Insecticide Action and Resistance. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59549-3_12

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  • DOI: https://doi.org/10.1007/978-3-642-59549-3_12

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