Abstract
Evidence has accumulated suggesting that melatonin, the major endocrine product of the pineal gland - as a well-preserved molecule through evolution - is involved in the feedback between neuroendocrine and immune functions. At present, we are beginning to understand the mechanisms of action by which melatonin affects cellular functions. In this article, we present a critical review of the numerous reports on the influence of melatonin on immune functions, focussing especially on possible underlying molecular pathways.
Keywords
- Vasoactive Intestinal Peptide
- Jurkat Cell
- Pineal Gland
- Melatonin Receptor
- Human Peripheral Blood Lymphocyte
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Liebmann, P.M., Wölfler, A., Schauenstein, K. (2001). Melatonin and Immune Functions. In: Bartsch, C., Bartsch, H., Blask, D.E., Cardinali, D.P., Hrushesky, W.J.M., Mecke, D. (eds) The Pineal Gland and Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59512-7_19
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