Abstract
In the general surgical population, the risk of death within 30 days of an operation is estimated at between 0.7% and 1.7% for most operations and only rises to between 4 and 10% for more risky operations such as cardiac or vascular surgery. However, data from a number of sources suggests that there are a group of surgical patients whose post-operative mortality is between 15 and 35% (Table 1). In England, Wales and Northern Ireland, approximately 2.8 million surgical operations are performed each year and approximately 20000 deaths within 30 days of operation are reported to the National Confidential Enquiry into Post Operative Deaths (NCEPOD). Of these deaths 87% were aged over 60 and 77% were over 70 years of age. Eighty-five percent of these patients had coexisting medical disorders, 45% had significant cardiovascular disease and 30% had significant respiratory disease [1]. The surgeons performing the surgery considered that there was a definite risk of death in nearly 60% of these cases and death was expected in nearly 10% of cases. Respiratory disorders were implicated in nearly 40% of these deaths and cardiac disorders were implicated in over 35% of deaths. Despite this, only 32% of these patients were admitted to an intensive care unit (ICU) or other high care area such as a high dependency unit (HDU). NCEPOD has recognized that those patients who die after surgery are more likely to be elderly, have pre-existing medical disorders and that most deaths occur after abdominal, colorectal or major orthopedic surgery.
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References
Sherry KM (2000) Clinical Co-ordinator, NCEPOD. Demographics: National Confidential Enquiry into Perioperative Deaths (NCEPOD). Clin Intensive Care 11:2–3
Edwards AE, Seymour DG, McCarthy JM, Crumplin MK (1996) A 5-year survival study of general surgical patients aged 65 years and over. Anaesthesia 51:3–10
Cook TM, Day CJ (1998) Hospital mortality after urgent and emergency laparotomy in patients aged 65 yr and over. Risk and prediction of risk using multiple logistic regression analysis. Br J Anaesth 80:776–781
Boyd AD, Tremblay RE, Spencer FC, Bahnson HT (1959) Estimation of cardiac output soon after intracardiac surgery with cardiopulmonary bypass. Ann Surg 613–626
Clowes GHAJ, Del Guercio LRM (1960) Circulatory response to trauma of surgical operations. Metabolism 67–81
Clowes GH, Jr., Vucinic M, Weidner MG (1966) Circulatory and metaboUc alterations associated with survival or death in peritonitis: clinical analysis of 25 cases. Ann Surg 163:866–885
Shoemaker WC (1972) Cardiorespiratory patterns of surviving and nonsurviving postoperative patients. Surg Gynecol Obstet 134:810–814
Shoemaker WC, Montgomery ES, Kaplan E, Elwyn DH (1973) Physiologic patterns in surviving and nonsurviving shock patients. Use of sequential cardiorespiratory variables in defining criteria for therapeutic goals and early warning of death. Arch Surg 106:630–636
Shoemaker WC, Czer LS (1979) Evaluation of the biologic importance of various hemodynamic and oxygen transport variables: which variables should be monitored in postoperative shock? Crit Care Med 7:424–431
Vacanti CJ, VanHouten RJ, Hill RC (1970) A statistical analysis of the relationship of physical status to postoperative mortality in 68,388 cases. Anesth Analg 49:564–566
Deitch EA (1993) Overview of multiple organ failure. In: Lumb PD, Shoemaker WC (eds) Critical care: State of the art. Society of Critical Care Medicine, Anaheim, pp 131–168
Kirkpatrick CJ BF, Klein CJ, Hauptmann S, Klosterhalfen B (1996) The role of the microcirculation in multiple organ dysfunction syndrome: a review and perspective. Virchows Arch 427: 461–476
Livingston DH, Mosenthal AC, Deitch E A (1995) Sepsis and multiple organ dysfunction syndrome: a clinical-mechanistic overview. New Horiz 3:257–266
Granger DN (1988) Role of xanthine oxidase and granulocytes in ischemia-reperfusion injury. Am J Physiol 255:H1269–H1275
Goldman L, Caldera DL, Nussbaum SR, et al (1977) Multifactorial index of cardiac risk in non-cardiac surgical procedures. N Engl J Med 297:845–850
Gopeland GP, Jones D, Walters M (1991) POSSUM: a scoring system for surgical audit. Br J Surg 78:355–360
Eagle KA, Brundage BH, Chaitman BR, et al (1996) Guidehnes for perioperative cardiovascular evaluation for noncardiac surgery. Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidehnes. Committee on Perioperative Cardiovascular Evaluation for Noncardiac Surgery. Circulation 93:1278–1317
Shoemaker WC, Appel PL, Kram HB, Waxman K, Lee TS (1988) Prospective trial of supranormal values of survivors as therapeutic goals in high-risk surgical patients. Chest 94:1176–1186
Savino JA, Del Guercio LR (1985) Preoperative assessment of high risk surgical patients. Surg Clin North Am 65:763–791
Older P, Smith R, Courtney P, Hone R (1993) Preoperative evaluation of cardiac failure and ischemia in elderly patients by cardiopulmonary exercise testing. Chest 104:701–704
Mangano DT, Browner WS, Hollenberg M, London M J, Tubau JF, Tateo IM (1990) Association of perioperative myocardial ischemia with cardiac morbidity and mortality in men undergoing noncardiac surgery. The Study of Perioperative Ischemia Research Group. N Engl J Med 323: 1781–1788
Mella J, Biffin A, Radcliffe AG, Stamatakis JD, Steele RJ (1997) Population-based audit of colorectal cancer management in two UK healthcare regions. Colorectal Cancer Working Group Royal College of Surgeons Clinical Epidemiology and Audit Unit. Br J Surg 84:1731–1736
Anderson I (2000) The surgeon. Consensus Meeting: Management of the High Risk Surgical patient. Clin Intensive Care 11:8–10
Porter GS, Soskolne GL, Yakimets WW, Newman SC (1998) Surgeon-related factors and outcome in rectal cancer. Ann Surg 227:157–167
Shoemaker WC, Appel PL, Waxman K, Schwartz S, Chang P (1982) Clinical trial of survivors’ cardiorespiratory patterns as therapeutic goals in critically ill postoperative patients. Crit Care Med 10:398–403
Schultz RJ, Whitfield GF, LaMura JJ, Raciti A, Krishnamurthy S (1985) The role of physiologic monitoring in patients with fractures of the hip. J Trauma 25:309–316
Berlauk JF, Abrams JH, Gilmour I J, O’Connor SR, Knighton DR, Cerra FB (1991) Preoperative optimization of cardiovascular hemodynamics improves outcome in peripheral vascular surgery. A prospective, randomized clinical trial. Ann Surg 214:289–297
Fleming A, Bishop M, Shoemaker W, et al (1992) Prospective trial of supranormal values as goals of resuscitation in severe trauma. Arch Surg 127:1175–1179
Boyd O, Grounds RM, Bennett ED (1993) A randomized clinical trial of the effect of deliberate perioperative increase of oxygen delivery on mortality in high-risk surgical patients. JAMA 270: 2699–2707
Bishop MH, Shoemaker WC, Appel PL, et al (1995) Prospective, randomized trial of survivor values of cardiac index, oxygen delivery, and oxygen consumption as resuscitation endpoints in severe trauma. J Trauma 38:780–787
Ziegler DW, Wright JG, Choban PS, Flancbaum L (1997) A prospective randomized trial of preoperative “optimization” of cardiac function in patients undergoing elective peripheral vascular surgery. Surgery 122:584–592
Sinclair S, James S, Singer M (1997) Intraoperative intravascular volume optimisation and length of hospital stay after repair of proximal femoral fracture: randomised controlled trial. Br Med J 315:909–912
Wilson J, Woods I, Fawcett J, et al (1999) Reducing the risk of major elective surgery: randomised controlled trial of preoperative optimisation of oxygen delivery. Br Med J 318:1099–1103
Polonen P, Ruokonen E, Hippelainen M, Poyhonen M, Takala J (2000) A prospective, randomized study of goal-oriented hemodynamic therapy in cardiac surgical patients. Anesth Analg 90: 1052–1059
Lobo SMA, Salgado PF, Castillo VGT, et al (2000) Effects of maximizing oxygen delivery on morbidity and mortality in high-risk surgical patients. Crit Care Med 28:3396–3404
Bender JS, Smith-Meek MA, Jones CE (1997) Routine pulmonary artery catheterization does not reduce morbidity and mortality of elective vascular surgery: results of a prospective, randomized trial. Ann Surg 226:229–236
Valentine RJ, Duke ML, Inman MH, et al (1998) Effectiveness of pulmonary artery catheters in aortic surgery: a randomized trial. J Vasc Surg 27:203–211
Hayes MA, Timmins AC, Yau EH, Palazzo M, Hinds CJ, Watson D (1994) Elevation of systemic oxygen delivery in the treatment of critically ill patients. N Engl J Med 330:1717–1722
Gattinoni L, Brazzi L, Pelosi P, et al (1995) A trial of goal-oriented hemodynamic therapy in critically ill patients. SvO2 Collaborative Group. N Engl J Med 333:1025–1032
Tuchschmidt J, Fried J, Astiz M, Rackow E (1992) Elevation of cardiac output and oxygen delivery improves outcome in septic shock. Chest 102:216–220
Mangano DT, Layug EL, Wallace A, Tateo I (1996) Effect of atenolol on mortality and cardiovascular morbidity after noncardiac surgery. Multicenter Study of Perioperative Ischemia Research Group. N Engl J Med 335:1713–1720
Poldermans D, Boersma E, Bax JJ, et al (1999) The effect of bisoprolol on perioperative mortality and myocardial infarction in high-risk patients undergoing vascular surgery. Dutch Echocardiographic Cardiac Risk Evaluation Applying Stress Echocardiography Study Group. N Engl J Med 341:1789–1794
Lee TH (1999) Reducing cardiac risk in noncardiac surgery. N Engl J Med 341:1838–1840
Mythen MG, Webb AR (1995) Perioperative plasma volume expansion reduces the incidence of gut mucosal hypoperfusion during cardiac surgery. Arch Surg 130:423–429
Guest JF, Boyd O, Hart WM, Grounds RM, Bennett ED (1997) A cost analysis of a treatment policy of a deliberate perioperative increase in oxygen delivery in high risk surgical patients. Intensive Care Med 23:85–90
Grocott MPW, Ball JAS (2000) Consensus Meeting: Management of the high risk surgical patient. 13–14 April 2000. Christ’s College Cambridge. Clin Intensive Care 11:1–19
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Grounds, R.M., Rhodes, A., Bennett, E.D. (2001). Reducing Surgical Mortality and Complications. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2001. Yearbook of Intensive Care and Emergency Medicine 2001, vol 2001. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59467-0_6
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DOI: https://doi.org/10.1007/978-3-642-59467-0_6
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