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Regional Differences in Vascular Reactivity in Sepsis and Endotoxemia

  • Conference paper
Yearbook of Intensive Care and Emergency Medicine 2001

Part of the book series: Yearbook of Intensive Care and Emergency Medicine 2001 ((YEARBOOK,volume 2001))

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Abstract

During human sepsis and shock, hypotension is associated with a high blood flow from the heart, particularly after fluid loading [1]. The hypotension is relatively refractory to vasoconstricting drugs, such as norepinephrine, used in attempts to treat the syndrome. The fall in vascular resistance is presumably not equally distributed among vascular beds, with hyperperfusion in some, and hypofusion in other, regions. For instance, human studies have documented a rise in coronary blood flow for a given cardiac workload and a decreased blood flow in the renal vascular bed [2]. Similarly, the hepatosplanchnic region can suffer from a decreased blood flow, while skeletal muscle may be relatively‘overperfused’. Studies in humans are hampered by methodological difficulties and none has been able to address the various regional changes at the same time [2].

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Authors
  1. A. B. J. Groeneveld
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  2. H. A. Piepot
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  3. P. Sipkema
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Editors and Affiliations

  1. Department of Intensive Care Erasme Hospital, Free University of Brussels, Route de Lennik 808, B-1070, Brussels, Belgium

    Jean-Louis Vincent (Head) (Head)

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Groeneveld, A.B.J., Piepot, H.A., Sipkema, P. (2001). Regional Differences in Vascular Reactivity in Sepsis and Endotoxemia. In: Vincent, JL. (eds) Yearbook of Intensive Care and Emergency Medicine 2001. Yearbook of Intensive Care and Emergency Medicine 2001, vol 2001. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59467-0_19

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  • DOI: https://doi.org/10.1007/978-3-642-59467-0_19

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