Skip to main content
SpringerLink
Log in

Neue Forschungsergebnisse zur Clozapin-induzierten Agranulozytose

  • Conference paper
Leponex

  • 59 Accesses

Zusammenfassung

Seit den ersten Berichten über das gehäufte Auftreten von Agranulozytosen unter Clozapin-Behandlung im Jahr 1975 in Finnland stellen medikamentös induzierte Blutbildstörungen auch für den Psychiater eine zwar seltene, jedoch klinisch wichtige Nebenwirkung dar. Insbesondere die frühzeitige Erkennung einer Agranulozytose ist für die betroffenen Patienten von vitaler Bedeutung, weil in diesem Fall ein sofortiges Absetzen des Clozapins und eine Zuweisung an eine entsprechende internistische Fachabteilung erforderlich ist.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 49.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 84.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Corzo D, Yunis JJ, Salazar M et al. (1995) The major histocompatibility complex region marked by hsp70–1 and hsp70–2 variants is associated with clozapine–induced agranulocytosis in 2 different ethnic–groups. Blood 86: 3835–3840

    PubMed  CAS  Google Scholar 

  • Drexler HG, Zaborski M, Quentmeier H (1997) Cytokine response profiles of human myeloid factor-dependent leukemia cell lines. Leukemia 11 (5): 701–708

    Article  PubMed  CAS  Google Scholar 

  • Fehsel K, Löffler S, Henning U, Kolb-Bachofen V, Klimke A (2000) The atypical antipsychotic drug clozapine sensitizes for granulocyte apoptosis. Blood (submitted )

    Google Scholar 

  • Furusawa S, Ohashi Y, Asanoi H (1996) Vesnarinone-induced granulocytopenia: incidence in Japan and recommendations for safety. J Clin Pharmacol 36 (5): 477–481

    PubMed  CAS  Google Scholar 

  • Gardner I, Zahid N, MacCrimmon D et al. (1998a) A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes. Molecular Pharmacology 53:991–998

    CAS  Google Scholar 

  • Gardner I, Leeder JS, Chin T, Zahid N, Uetrecht JP (1998b) A comparison of the covalent binding of clozapine and olanzapine to human neutrophils in vitro and in vivo. Mol Pharmacol 53: 999–1008

    CAS  Google Scholar 

  • Gerson SL, Arce C, Meltzer HY (1994) N-desmethylclozapine: a clozapine metabolite that suppresses haemopoesis. Br J Haematol 86: 555–561

    Article  PubMed  CAS  Google Scholar 

  • Grimm R (1987) Leponex (Clozapin) - Prototyp atypischer Neuroleptika. Wander Pharma, Bern

    Google Scholar 

  • Guest I, Sokoluk B, MacCrimmon J et al. (1998) Examination of possible toxic and immune mechanisms of clozapine-induced agranulocytosis. Toxicology 131: 53–65

    Article  PubMed  CAS  Google Scholar 

  • Idanpaan-Heikkila J, Aihava E, Olkinoura M, Palva I (1975) Clozapine and agranulocytosis. Lancet 6: 11

    Google Scholar 

  • Klimke A, Klieser E (1995) Das atypische Neuroleptikum Clozapin. Aktueller Kenntnisstand and neuere klinische Aspekte. Fortschritte Neurologie Psychiatrie 63: 173–193

    Article  CAS  Google Scholar 

  • Henning U, Löffler S, Krieger K, Klimke A (2000) Intracellular uptake of the atypical neuro-leptic clozapine. Pharmacopsychiatry (submitted )

    Google Scholar 

  • Lieberman JA, Yunis J, Egea E et al. (1990) HLA-B38, DR4, DQw3 and clozapine-induced agranulocytosis in Jewish patients with schizophrenia. Arch Gen Psychiatry 47: 945–948

    PubMed  CAS  Google Scholar 

  • Liu ZC, Uetrecht JP (1995) Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells. Journal of Pharmacology and Experimental Therapeutics 275: 1476–1483

    PubMed  CAS  Google Scholar 

  • Löffler S, Fehsel K, Fischer J, Henning U, Kolb-Bachofen V, Klimke A (2000) Markers for apoptosis and cytokine levels during clozapine-induced agranulocytosis: a case report. British Journal of Psychiatry (submitted)

    Google Scholar 

  • Nabeshima R, Aizawa S, Nakano M et al. (1997) Effects of vesnarinone on the bone marrow stromal cell-dependent proliferation and differentiation of HL60 cells in vitro. Exp Hematology 25: 509–515

    CAS  Google Scholar 

  • Pirmohamed M, Park K (1997) Mechanism of clozapine-induced agranulocytosis: current status of research and implications for drug development. CNS Drugs 7: 139–158

    Article  CAS  Google Scholar 

  • Pisciotta AV, Konings SA (1994) 51Cr release assay of clozapine-induced cytotoxicity: evidence for immunogenic mechanism. Journal of Clinical Psychiatry 55:143–148

    PubMed  Google Scholar 

  • Pollmächer T, Hinze-Selch D, Mullington J (1996) Effects of clozapine on plasma cytokine and soluble cytokine receptor levels. Journal of Clinical Psychopharmacology 16: 403–409

    Article  PubMed  Google Scholar 

  • Safa AR, Agresti M, Bryk D, Tamai I (1994) N-(p-azido-3-[125I]iodophenethyl)spiperone binds to specific regions of p-glycoprotein and another multidrug binding protein, spiperophilin, in human neuroblastoma cells. Biochemistry 33 (1): 256–265

    Article  PubMed  CAS  Google Scholar 

  • Sato Y, Matsumori A, Sasayama S (1995) Inotropic agent vesnarinone inhibits cytokine production and E-selectin expression in human umbilical vein endothelial cells. J Mol Cell Cardiol 27 (10): 2265–2273

    Article  PubMed  CAS  Google Scholar 

  • Sperner-Unterweger B, Gaggl S, Fleischhacker WW et al. (1993) Effects of clozapine on hematopoiesis and the cytokine system. Biological Psychiatry 34: 536–543

    Article  PubMed  CAS  Google Scholar 

  • Sperner-Unterweger B, Czeipek I, Gaggl S et al. (1998) Treatment of severe clozapine-induced neutropenia with granulocyte colony-stimulating factor (G-CSF). Remission despite continuous treatment with clozapine. British Journal of Psychiatry 172: 82–84

    Article  PubMed  CAS  Google Scholar 

  • Syed SK, Christopherson RI, Roufogalis BD (1998) Reversal of vinblastine transport by chlorpromazine in membrane vesicles from multidrug-resistant human CCRF-CEM leukaemia cells. Br J Cancer 78 (3): 321–327

    Article  PubMed  CAS  Google Scholar 

  • Uetrecht JP (1992) The role of leukocyte-generated reactive metabolites in the pathogenesis of idiosyncratic drug reactions. Drug Metabolism Reviews 24 (3): 299–366

    Article  PubMed  CAS  Google Scholar 

  • Uetrecht JP, Mo HH, McKnight E, McClelland R (1995) Oxidation of aminopyrine by hypo-chlorite to a reactive dication: Possible implications for aminopyrine-induced agranulocytosis. Chem Res Toxicol 8: 226–233

    Article  PubMed  CAS  Google Scholar 

  • Valevski A, Klein T, Gazit E, Meged S, Stein D, Elizur A, Narinsky ER, Kutzuk D, Weizman A (1998) HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients. Eur J Immunogenet 25 (1): 11–13

    Article  PubMed  CAS  Google Scholar 

  • Weinmann P, Gaehtgens P, Walzog B (1999) Bel-X1- and Bax-a-mediated regulation of apoptosis of human neutrophils via caspase-3. Blood 93: 3106–3115

    PubMed  CAS  Google Scholar 

  • Yunis JJ, Corzo D, Salazar M et al. (1995) HLA associations in clozapine—induced agranulocytosis. Blood 86: 1177–1183

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. A. Klimke
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. S. Löffler
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. K. Fehsel
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. U. Henning
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Psychiatrische Klinik und Poliklinik, Univ.-Krankenhaus Eppendorf, Martinistraße 52, D-20246, Hamburg, Deutschland

    D. Naber

  2. Psychiatrische Universitätskliniken Basel, Wilhelm-Kleine-Straße 27, CH-4025, Basel, Switzerland

    F. Müller-Spahn

Rights and permissions

Reprints and permissions

Copyright information

© 2001 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Klimke, A., Löffler, S., Fehsel, K., Henning, U. (2001). Neue Forschungsergebnisse zur Clozapin-induzierten Agranulozytose. In: Naber, D., Müller-Spahn, F. (eds) Leponex. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59454-0_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59454-0_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41135-2

  • Online ISBN: 978-3-642-59454-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation