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Sonderformen der Multiplen Sklerose

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Multiple Sklerose

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Zusammenfassung

Als Grundlagen der Klassifikation einer entzündlichen ZNS-Erkrankung als Multiple Sklerose (MS) dienen zum einen klinische und verlaufskinetische Parameter, zum anderen zusatzdiagnostische Befunde (Noseworthy et al. 2000). Zu letzteren gehören charakteristische Liquorveränderungen mit intrathekaler IgG-Synthese, Latenzverzögerungen in den zentralen Leitungsstudien als neurophysiologisches Korrelat der Entmarkung und periventrikuläre Marklagerherde in der Magnetresonanztomografie. Die Zusammenschau dieser Befunde lässt die Diagnose MS mehr oder weniger wahrscheinlich bzw. als sicher erscheinen, entsprechend den international anerkannten Poser-Kriterien (Poser et al. 1983). Es gibt eine ganze Reihe entzündlicher ZNS-Erkrankungen, die die oben genannten Kriterien teilweise erfüllen, darüber hinaus aber charakteristische Unterschiede aufweisen. Dazu gehört die Marburg-Variante der MS und die davon abzugrenzende akute disseminierte Enzephalomyelitis (ADEM), die Neuromyelitis optica (Devic-Syndrom) und der Symptomenkomplex, der sich hinter dem Epinym der Schilder-Erkrankung verbirgt. Entsprechend der relativen Seltenheit dieser Krankheitsbilder im Vergleich zur MS ist nicht nur deren Klassifikation häufig schwierig und erfordert teils eine bioptische Abklärung, es fehlen auch größere kontrollierte Therapiestudien. Die Behandlungsoptionen basieren deshalb häufig auf Einzelfallbeschreibungen.

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Authors
  1. G. Stoll
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  2. W. Brück
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Editor information

Editors and Affiliations

  1. Klinik und Poliklinik für Neurologie, Universität Rostock, Gehlsheimer Str. 20, 18055, Rostock, Germany

    Uwe K. Zettl  & Eilhard Mix PhD  & 

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© 2001 Springer-Verlag Berlin Heidelberg

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Stoll, G., Brück, W. (2001). Sonderformen der Multiplen Sklerose. In: Zettl, U.K., Mix, E. (eds) Multiple Sklerose. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59453-3_7

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  • DOI: https://doi.org/10.1007/978-3-642-59453-3_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41121-5

  • Online ISBN: 978-3-642-59453-3

  • eBook Packages: Springer Book Archive

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