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Viral Evasion of Natural Killer Cells During Human Cytomegalovirus Infection

  • Chapter
Viral Proteins Counteracting Host Defenses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 269))

Abstract

Cytotoxic T cells are major players in the immune defence against human cytomegalovirus (HCMV). The virus has, however, developed several mechanisms to escape from this control. In particular, it down-regulates cell surface expression of HLA class I molecules. Because natural killer (NK) cells recognize and eliminate cells that lack HLA class I molecules. HCMV-infected cells could be more susceptible to NK lysis. In this review, we discuss the role played by NK cells in immune defence against HCMV and we describe potential strategies the virus has developed to escape from NK cell-mediated lysis. We focus in particular on a newly described protein, HCMV gpUL40, that induces cell surface expression of HLA-E, a non-classical class I molecule known to regulate NK cell functions.

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Authors and Affiliations

  1. Centre National de la Recherche Scientifique, CNRS UMR 6097, Institut de Pharmacologie Moleculaire et Cellulaire, 660 Route des Lucioles, Sophia Antipolis, 06560, Valbonne, France

    V. M. Braud

  2. Department of Medicine, University of Wales College of Medicine, Cardiff, CF14 4XN, UK

    P. Tomasec & G. W. G. Wilkinson

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  1. V. M. Braud
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  2. P. Tomasec
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  3. G. W. G. Wilkinson
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Editors and Affiliations

  1. Max von Pettenkofer Institute, University of Munich, Pettenkoferstr. 9a, 80336, Munich, Germany

    Ulrich H. Koszinowski

  2. Robert Koch-Institut, Fachgebiet 1.2 Virale Infektionen, Nordufer 20, 13353, Berlin, Germany

    Hartmut Hengel

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Braud, V.M., Tomasec, P., Wilkinson, G.W.G. (2002). Viral Evasion of Natural Killer Cells During Human Cytomegalovirus Infection. In: Koszinowski, U.H., Hengel, H. (eds) Viral Proteins Counteracting Host Defenses. Current Topics in Microbiology and Immunology, vol 269. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59421-2_8

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  • DOI: https://doi.org/10.1007/978-3-642-59421-2_8

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