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Strategies for the Identification and Analysis of Viral Immune-Evasive Genes — Cytomegalovirus as an Example

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Viral Proteins Counteracting Host Defenses

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 269))

Abstract

Co-evolution of herpesviruses with their hosts has resulted in multiple interactions between viral genes and cellular functions. Some interactions control genomic maintenance and replication in specific tissues, others affect the immune control at various stages. Few immunomodulatory functions of genes can be predicted by sequence homology. The majority of genes with immunomodulatory properties only become apparent in functional assays. This chapter reviews procedures which have been used for successful identification of immunomodulatory genes in the past and deals with recent methods which may be applicable for the identification of additional immunomodulatory functions unknown so far.

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Authors and Affiliations

  1. Max-von-Pettenkofer Institut, Ludwig-Maximilians-Universität München, 80336, München, Germany

    A. Gutermann, A. Bubeck, M. Wagner, U. Reusch, C. Ménard & U. H. Koszinowski

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  1. A. Gutermann
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  2. A. Bubeck
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  3. M. Wagner
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  4. U. Reusch
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  5. C. Ménard
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  6. U. H. Koszinowski
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Editor information

Editors and Affiliations

  1. Max von Pettenkofer Institute, University of Munich, Pettenkoferstr. 9a, 80336, Munich, Germany

    Ulrich H. Koszinowski

  2. Robert Koch-Institut, Fachgebiet 1.2 Virale Infektionen, Nordufer 20, 13353, Berlin, Germany

    Hartmut Hengel

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© 2002 Springer-Verlag Berlin Heidelberg

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Gutermann, A., Bubeck, A., Wagner, M., Reusch, U., Ménard, C., Koszinowski, U.H. (2002). Strategies for the Identification and Analysis of Viral Immune-Evasive Genes — Cytomegalovirus as an Example. In: Koszinowski, U.H., Hengel, H. (eds) Viral Proteins Counteracting Host Defenses. Current Topics in Microbiology and Immunology, vol 269. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59421-2_1

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  • DOI: https://doi.org/10.1007/978-3-642-59421-2_1

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63974-6

  • Online ISBN: 978-3-642-59421-2

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