Abstract
Mice suffering from melanoma can be cured by treatment with a recombinant antibody-lymphotoxin-a fusion protein. In order to characterize the involvement of T cells in this syngeneic tumor model, the T cell receptor repertoire was analyzed both quantitatively and qualitatively. In this connection, quantitative analysis of the T cell receptors displayed only a modest overexpression in some of the variable beta chain families over the course of therapy. Clonotypic mapping, however, revealed a marked increase in the number of clonally expanded T cells among the tumor-infiltrating T cells, suggesting a specific activation.
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© 2002 Springer-Verlag Berlin Heidelberg
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Schrama, D., >thor Straten, P., Bröcker, EB., Reisfeld, R.A., Becker, J.C. (2002). Cytokine Fusion Protein Treatment. In: Dummer, R., Nestle, F.O., Burg, G. (eds) Cancers of the Skin. Recent Results in Cancer Research, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59410-6_22
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DOI: https://doi.org/10.1007/978-3-642-59410-6_22
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