Abstract
In discussions amongst the public and the scientific community, doubts are repeatedly raised concerning the efficacy of sunscreens in preventing cutaneous malignancy. This article summarizes the most reliable references on UV protection and epithelial skin cancer and discusses the role of UV protection in melanoma prevention. We conclude that there is substantial evidence that UV protection is able to reduce the risk of actinic keratosis, squamous cell carcinoma and probably also the risk of melanoma.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Applegate LA, Scaletta C, Panizzon R, Niggli H, Frenk E (1999) In vivo induction of pyrimidine dimers in human skin by UVA radiation: initiation of cell damage and/or intercellular communication? Int J Mol Med 3:467–472.
Autier P, Dor JF, Ng S, Linard D, Panizzon R, Lejeune FJ, Guggisberg D, Eggermont AM (1999) Sunscreen use and duration of sun exposure: a double-blind, randomized trial (see comments). J Natl Cancer Inst 91:1304–1309.
Boni R, Dummer R, Burg G (1995) Nehmen Hauttumoren zu? Schweiz Med Wochenschr 125:1619–1624.
Burren, R, Scaletta C, Frenk E, Panizzon RG, Applegate LA (1998) Sunlight and carcinogenesis: expression of p53 and pyrimidine dimers in human skin following UVA I, UVA I + II and solar simulating radiations. Int J Cancer 76:201–206.
Dummer R, Osterwalder U (2000) UV transmission of summer clothing in Switzerland and Germany (letter). Dermatology 200:81–82.
Dummer R, Maier T, Bloch PH, Burg G (2001) Photoprotektion: Lichtschutzmaßnahmen zum Schutz vor akuten und chronischen Hautschaden. Swiss Med Forum 14:364–368.
Eller MS, Ostrom K, Gilchrest BA (1996) DNA damage enhances melanogenesis. Proc Natl Acad Sci USA 93:1087–1092.
Eller MS, Maeda T, Magnoni C, Atwal D, Gilchrest BA (1997) Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response. Proc Natl Acad Sci USA 94:12627–12632.
Frei T, Dummer R, Gehrig R (1999) Die UV-Belastung in der Schweiz: Abhangigkeit von Ort und Zeit und ihre Bedeutung für die Haut. Praxis 88:1023–102.
Gallagher RP, Rivers JK, Lee TK, Bajdik CD, McLean DI, Coldman AJ (2000) Broad-spec- trum sunscreen use and the development of new nevi in white children: a randomized controlled trial. JAMA 283:2955–2960.
Garland CF, Garland FC, Gorham ED (1993) Rising trends in melanoma. An hypothesis concerning sunscreen effectiveness (see comments). Ann Epidemiol 3:103–110.
Gilchrest BA, Eller MS, Geller AC, Yaar M (1999) The pathogenesis of melanoma induced by ultraviolet radiation. N Engl J Med 340:1341–1348.
Green A, Williams G, Neale R, Hart V, Leslie D, Parsons P, Marks GC, Gaffney P, Battistutta D, Frost C, Lang C, Russell A (1999) Daily sunscreen application and betacarotene supplementation in prevention of basal-cell and squamous-cell carcinomas of the skin: a randomised controlled trial (see comments). Lancet 354:723–729.
Ley RD (1997) Ultraviolet radiation A-induced precursors of cutaneous melanoma in Mono- delphis domestica. Cancer Res 57:3682–3684.
Lim HW, Naylor M,Honigsmann H, Gilchrest BA, Cooper K, Morison W, Deleo VA, Scherschun L (2001) American Academy of Dermatology Consensus Conference on UVA Protection of Sunscreens: summary and recommendations. Washington, DC, 4 February 2000. J Am Acad Dermatol 44:505–508
Naylor MF (1997) Erythema, skin cancer risk, and sunscreens. Arch Dermatol 133:373–375.
Naylor MF, Boyd A, Smith DW, Cameron GS, Hubbard D, Neldner KH (1995) High sun pro-tection factor sunscreens in the suppression of actinic neoplasia. Arch Dermatol 131:170–175.
Rigel DS, Naylor M, Robinson J (2000) What is the evidence for a sunscreen and melanoma controversy Arch Dermatol 136:1447–1449.
Setlow RB, Grist E, Thompson K, Woodhead AD (1993) Wavelengths effective in induction of malignant melanoma. Proc Natl Acad Sci USA 90:6666–6670.
Thompson SC, Jolley D, Marks R (1993) Reduction of solar keratoses by regular sunscreen use (see comments). N Engl J Med 329:1147–1151.
Wang SQ, Setlow R, Berwick M, Polsky D, Marghoob AA, Kopf AW, Bart RS (2001) Ultraviolet A and melanoma: a review. J Am Acad Dermatol 44:837–846.
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Dummer, R., Maier, T. (2002). UV Protection and Skin Cancer. In: Dummer, R., Nestle, F.O., Burg, G. (eds) Cancers of the Skin. Recent Results in Cancer Research, vol 160. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59410-6_2
Download citation
DOI: https://doi.org/10.1007/978-3-642-59410-6_2
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-63969-2
Online ISBN: 978-3-642-59410-6
eBook Packages: Springer Book Archive