Abstract
Cervical cancer is the second leading cause of cancer in women worldwide [1,2]. Human Papillomaviruses (HPV) have been identified as the most important viral group associated with benign and malignant neoplasia in humans [3]. Several studies have demonstrated that infection with certain HPV types may progress over a period of years through the various stages of cervical intraepithelial neoplasia (CIN) to invasive squamous carcinoma [4,5,6]. There are more than 80 different HPV types that have been identified [7,8]. Currently, there are more than 20 HPV types that have been found linked to cervical cancer [9]. This group is further subdivided into three categories designated as low, medium and high to differentiate between the relative risk for developing cervical carcinoma from any particular HPV type infection [10]. From the high risk category HPV 16 ranks first followed by HPV 18 in being found at a higher frequency in CIN and cervical carcinomas [1,11]. As of today, HPV 45 is considered a medium/high risk type but there is supporting evidence indicating that HPV 45 follows HPV 18 in frequency and that it should be classified as a high risk type [1, 12].
Keywords
- Cervical Cancer
- Cervical Intraepithelial Neoplasia
- Risk Type
- Invasive Squamous Carcinoma
- Digene Hybrid Capture
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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© 2002 Springer-Verlag Berlin Heidelberg
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Henriquez, M.L., Caplin, B.E., Rasmussen, R.P. (2002). Two Color Multiplexing and Typing of Human Papillomavirus Types 16,18 and 45 on LightCycler. In: Dietmaier, W., Wittwer, C., Sivasubramanian, N. (eds) Rapid Cycle Real-Time PCR — Methods and Applications. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59397-0_16
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DOI: https://doi.org/10.1007/978-3-642-59397-0_16
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