Zusammenfassung
Ndiesem Buchkapitel soll die Problematik von Lebermetastasen, die eine Schnittmenge der verschiedensten Tumorerkrankungen bilden, aus nuklearmedizinischer Sicht beleuchtet werden. Mindestens so wichtig wie die Diagnostik sind dabei die vielfältigen therapeutischen Ansätze, die die Nuklearmedizin in die moderne Onkologie einbringt, und die noch weitreichende Umwälzungen dieses Fachgebiets gerade zu Beginn des neuen Jahrtausends mit sich bringen
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Literatur
Atmaram SH, Ganatra RD, Sharma SM, Ramanna L (1975) Functioning metastases in liver from thyroid carcinoma: Case report. J Nucl Med 16: 919–921
Avril N, Scheidhauer K, Kuhn W (2000) Breast cancer. In: Wieler HJ, Coleman RE (eds) PET in clinical oncology. Springer Steinkopff, Darmstadt, pp 355–372
Bell E, Grünwald F (1999) Radiojodtherapie bei benignen und malignen Schilddrüsenerkrankungen. Springer, Berlin Heidelberg New York Tokyo
Bender H, Bangard N, Metten N, Bangard M, Mezger J, Schomburg A, Biersack HJ (1999) Possible role of FDG-PET in the early prediction of therapy outcome in liver metastases of colorectal cancer.Hybridoma 18: 87–91
Bender H, Straehler-Pohl HJ (2000) PET in head and neck tumors. In: Wieler HJ, Coleman RE (eds) PET in clinical oncology. Springer Steinkopff, Darmstadt, pp 155–167
Bonnette P, Epardeau B, Frachon I, Bisson A, Caubarrere I, Mignot L, Corone C (1999) Report of 2 cases of pleural recurrences of surgically treated bronchogenic carcinoids. Diagnostic and therapeutic problems. Rev Mal Respir 16: 85–88
Boykin KN, Zibari GB, Lilien DL, McMillan RW, Aultman DF, McDonald JC (1999) The use of FDGpositron emission tomography for the evaluation of colorectal metastases of the liver. Am Surg 65: 1183–1185
Bretagne JF, Raoul JL, Bourguet P et al. (1988) Hepatic artery injection of I-131-labeled Lipiodol. Part 2: Preliminary results of therapeutic use in patients with hepatocellular carcinoma and liver metastases. Radiology 168: 547–550
Britton KE, Granowska M(1998) The diagnostic role of radiolabeled antibodies. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 871–892
Casara D, Busnardo B, Cimitan M (1981) Liver metastases from differentiated thyroid carcinoma. J Nucl Med Allied Sei 25: 53–54
Castellani MR, Di Bartolomeo M, Maffioli L, Zilembo N, Gasparini M, Buraggi GL (1991) [1311] metaiodobenzylguanidine therapy in carcinoid tumors. J Nucl Biol Med 35: 349–351
Cavalieri RR (1996) Nuclear imaging in the management of thyroid carcinoma. Thyroid 6: 485–492
Chatal JF, Mah M(1998) Therapeutic use of radiolabeled antibodies. In: Murray IPC, Ell PJ(eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 1101–1114
Clarke SEM(1998) Radioiodine therapy of the thyroid. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 1049–1062
Crippa F, Gavazzi C, Bozzetti F et al. (1997) The influence of blood glucose levels on [18F] fluorodeoxyglucose (FDG) uptake in cancer: A PET study in liver metastases from colorectal carcinomas. Tumori 83: 748–752
Delbeke D, Vitola JV, Sandler MP et al. (1997)Staging recurrent metastatic colorectal carcinoma with PET.J Nucl Med 38: 1196–1201
Dimitrakopoulou A, Strauss LG, Clorius JH et al. (1993) Studies with positron emission tomography after systemic administration of fluorine-18-uracil in patients with liver metastases from colorectal carcinoma. J Nucl Med 34: 1075–1081
Dimitrakopoulou-Strauss A, Strauss LG, Schlag P et al. (1998 a) Intravenous and intra-arterial oxygen-15-labeled water and fluorine-18-labeled fluorouracil in patients with liver metastases from colorectal carcinoma. J Nucl Med 39: 465–473
Dimitrakopoulou-Strauss A, Strauss LG, Schlag P, Hohenberger P, Möhler M, Oberdorfer F, van Kaick G(1998b) Fluorine-18-fluorouracil to predict therapy response in liver metastases from colorectal carcinoma. J Nucl Med 39: 1197–1202
Dresel S, Tatsch K, Zachoval R, Hahn K (1996) llllN-Octreotide- und 1231-MIBG-Szintigraphie in der Diagnostik von Dünndarmkarzinoiden. Nuklearmedizin 35: 53–58
Eising EG, Farahati J, Bier D, Knust EJ, Reiners C (1995) Somatostatinrezeptor-Szintigraphie bei medullären Schilddrüsenkarzinomen, GEP-Tumoren und Karzinoiden. Nuklearmedizin 34: 1–7
Findlay M, Young H, Cunningham D et al. (1996) Noninvasive monitoring of tumor metabolism using fluorodeoxyglucose and positron emission tomography in colorectal cancer liver metastases: Correlation with tumor response to fluorouracil. J Clin Oncol 14: 700–708
Fischer M (1998) Alternative approaches to targeting therapy. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 1115–1121
Frank-Raue K, Bihl H, Dorr U, Buhr H, Ziegler R, Raue F (1995) Somatostatin receptor imaging in persistent medullary thyroid carcinoma. Clin Endocrinol 42: 31–37
Fröhlich A, Diederichs CG, Staib L, Vogel J, Beger HG, Reske SN (1999)Detection of liver metastases from pancreatic cancer using FDG PET.J Nucl Med 40: 250–255
Furusawa M, Shimomura O, Tomiguchi S et al. (1992) Radionuclide therapy of Sipple Syndrome using iodine-131 metaiodobenzylguanidine. Kaku Igaku 29: 1133–1138
Graves MW, Zukerberg B, Walace K, Duncan D, Scheff A (1996) Isolated liver metastases from follicular thyroid cancer. Clin Nucl Med 21: 147–148
Grünwald F, Ruhlmann J, Kozak B, Overlack A, Christ F, Hotze A, Biersack HJ (1988) Nuklearmedizinische Diagnostik und Therapie von Fernmetastasen eines Phäochromozytoms. Dtsch Med Wochenschr 113: 297–299
Grünwald F, Menzel C, Bender H et al. (1998) Redifferentiation therapy - induced radioiodine uptake in thyroid cancer. J Nucl Med 39: 1903–1906
Grünwald F, Kälicke T, Feine U et al. (1999) Fluorine-18 fluorodeoxyglucose positron emission tomography in thyroid cancer: Results of a multicentre study. Eur J Nucl Med 26: 1547–1552
Guglielmi R, Pacella CM, Dottorini ME et al. (1999) Severe thyrotoxicosis due to hyperfunctioning liver metastasis from follicular carcinoma: Treatment with (131)1 and interstitial laser ablation. Thyroid 9: 173–177
Herba MJ, Illescas FF, Thirlwell MP, Boos GJ, Rosenthall L, Atri M, Bret PM (1988) Hepatic malignancies: Improved treatment with intraarterial Y-90. Radiology 169: 311–314
Hoefnagel CA, Lewington VJ (1998) MIBG therapy. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 1067–1081
Hoefnagel CA, Taal BG, Valdes Olmos RA (1991) Role of [131I] metaiodobenzylguanidine therapy in carcinoids. J Nucl Biol Med 35: 346–348
Hohenberger P, Strauss LG, Lehner B, Frohmuller S, Dimitrakopoulou A, Schlag P (1993) Perfusion of colorectal liver metastases and uptake of fluorouracil assessed by H2(15)0 and [18F] uracil positron emission tomography (PET). Eur J Cancer 29A: 1682–1686
Hosten N, Kreissig R, Puls R et al. (2000) Fusion von CT- und PET-Daten: Methode und klinische Bedeutung am Beispiel der Planung der laserinduzierten Thermotherapie von Lebermetastasen. Rofo Fortschr Geb Rontgenstr Neuen Bildgeb Verfahr 172: 630–635
Kälicke T, Schmitz A, Risse JH et al. (2000) Fluorine-18 fluorodeoxyglucose PET in infectious bone diseases: Results of histologically confirmed cases. Eur J Nucl Med 27: 524–528
Kim CK, Worsley DF, Lentle BC (1998) Scintigraphic diagnosis of tumors of the liver. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 775–782
Kissel J, Brix G, Bellemann ME et al. (1997) Pharmacokinetic analysis of 5-[18F] fluorouracil tissue concentrations measured with positron emission tomography in patients with liver metastases from colorectal adenocarcinoma. Cancer Res 57: 3415–3423
Kiemenz B, Taaleb KM(2000) Lung cancer. In: Wieler HJ, Coleman RE (eds) PET in clinical oncology. Springer Steinkopff, Darmstadt, pp 193–210
Knapp WH, Moser E, Bares R, Reske SN (1999) Tumoren. In: Büll U, Schicha H, Biersack HJ ETAL Etal. (Hrsg) Nuklearmedizin, 3. Aufl Thieme, Stuttgart New York, S 454–505
Konsensus Onko-PET (1997) Ergebnisse der 2. interdisziplinären Konsensuskonferenz in Ulm, 12. 9. 1997. Nuklearmedizin 36: 45–46
Krebs B, Frey M, Lellig U (1989) Jodspeichernde, hormonproduzierende Lebermetastase eines follikulären Schilddrüsenkarzinoms. RoFo Fortschr Geb Rontgenstr Nuklearmed 50: 489
Krenning EP, Kwekkeboom DJ, Reubi JC (1998) Peptide receptor scintigraphy in oncology. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 859–870
Krenning EP, Valkema R, Kooij PP et al. (2000) The role of radioactive somatostatin and its analogues in the control of tumor growth. Recent Results Cancer Res 153: 1–13
Lai DT, Fulham M, Stephen MS et al. (1996) The role of whole-body positron emission tomography with [ 18F)fluorodeoxyglucose in identifying operable colorectal cancer metastases to the liver. Arch Surg 131: 703–707
Lastoria S, Maurea S, Caraco C et al. (1993) Iodine-131 metaiodobenzylguanidine scintigraphy for localization of lesions in children with neuroblastoma: Comparison with computed tomography and ultrasonography. Eur J Nucl Med 20: 1161–1167
Liewendahl K, Välimäki M, Taavitsainen M(1993) Localization of hepatic metastases by radiolabelled anti-carcinoembryonic antigen antibody and meta-iodobenzylguanidine in a patient with medullary thyroid carcinoma. Eur J Nucl Med 20: 551–554
Mantaka P, Strauss AD, Strauss LG et al. (1999) Detection of treated liver metastases using fluorine-18-fluordeoxyglucose (FDG) and positron emission tomography (PET). Anticancer Res 19: 4443–4450
Moehler M, Dimitrakopoulou-Strauss A, Gutzier F, Raeth U, Strauss LG, Stremmel W (1998) 18F-labeled fluorouracil positron emission tomography and the prognoses of colorectal carcinoma patients with metastases to the liver treated with 5-fluorouracil. Cancer 83: 245–253
Moretti JL, Archer CM, Urbain JL (1998) Molecular biology in nuclear oncology. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 893–910
Nakagami Y, Nomura K, Kusakabe K, Miko N, Tsushima T, Demura H (1990) A case of malignant pheochromocytoma treated with 1311-metaiodobenzylguanidine and alpha-methyl-p-tyrosine. Jpn J Med 29: 329–333
Nakamoto Y, Higashi T, Sakahara H, Tamaki N, Kogire M, Imamura M, Konishi J (1999) Contribution of PET in the detection of liver metastases from pancreatic tumours. Clin Radiol 54: 248–252
Ogunbiyi OA, Flanagan FL, Dehdashti F et al. (1997) Detection of recurrent and metastatic colorectal cancer: Comparison of positron emission tomography and computed tomography. Ann Surg Oncol 4: 613–620
Orsolon P, Bagni B (1995) 1311 MIBG/lllIn octreotide mismatch in a patient with liver metastases secondary to a carcinoid of unknown origin. Minerva Endocrinol 20: 145–147
Otte A, Herrmann R, Heppeler A et al. (1999) Yttrium-90 DOTATOC: first clinical results. Eur J Nucl Med 26: 1439–1447
Perring S, Hind R, Fleming J et al. (1994) Dosimetrie assessment of radiolabelled Lipiodol as a potential therapeutic agent in colorectal liver metastases using combined CT and SPECT. Nucl Med Commun 15: 34–38
Prvulovich EM, Stein RC, Bomanji JB, Ledermann JA, Taylor I, Ell PJ (1998) Iodine-131-MIBG therapy of a patient with carcinoid liver metastases. J Nucl Med 39: 1743–1745
Raoul JL, Bourguet P, Bretagne JF et al. (1988) Hepatic artery injection of I-131-labeled Lipiodol. Part 1: Biodistribution study results in patients with hepatocellular carcinoma and liver metastases. Radiology 168: 541–545
Raoul JL, Guyader D, Bretagne JF et al. (1994) Randomized controlled trial for hepatocellular carcinoma with portal vein thrombosis: Intra-arterial iodine-131-iodized oil versus medical support. J Nucl Med 35: 1782–1787
Reske SN, Bares R, Büll U, Guhlmann A, Moser E, Wannenmacher MF(1996) Clinical value of positron emission tomography (PET) in oncologic questions: Results of an interdiseiplinary consensus conference. Nuklearmedizin 35: 42–52
Risse JH, Grünwald F, Bender H, Schüller H, Van Roost D, Biersack HJ (1999a) Recombinant human TSH in thyroid cancer and hypopituitarism due to sella metastasis. Thyroid 9: 1253–1256
Risse JH, Grünwald F, Strunk H, Kleinschmidt R, Bender H, Biersack HJ (1999b) I-131-Lipiodol therapy in liver neoplasms. Hybridoma 18: 83–85
Risse JH, Grünwald F, Kersjes W, Ayanna S, Palmedo H, Bender H, Biersack HJ (1999c) Intraarterielle Therapie von Lebermetastasen bei Mamma-Carcinom mit J-131-Lipiodol. Nuklearmedizin 38: A98
Risse JH, Palmedo H, Bender H (2000a) Malignant Melanoma. In: Bender H, Palmedo H, Biersack HJ, Valk PE (eds) Atlas of clinical PET in oncology. Springer, Berlin Heidelberg New York Tokyo, pp 37–49
Risse JH, Grünwald F, Kersjes W et al. (2000b) Intraarterial HCC therapy with I-131-Lipiodol. Cancer Biother Radio 15: 65–70
Rotman-Pikielny P, Reynolds JC, Barker WC, Yen PM, Skarulis MC, Sarlis NJ (2000) Recombinant human thyrotropin for the diagnosis and treatment of a highly functional metastatic Struma ovarii. J Clin Endocrinol Metab 85: 237–244
Rutgers EJT, Muller SH, Hoefnagel CA (1998) Use of intraoperative probes in surgical oncology. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 1025–1036
Schicha H, Dietlein M, Scheidhauer K (1999) Therapie mit offenen radioaktiven Stoffen. In: Büll U, Schicha H, Biersack HJ ETAL Etal. (Hrsg) Nuklearmedizin, 3. Aufl. Thieme, Stuttgart New York, S 512–545
Schlumberger MJ (1998) Papillary and follicular thyroid carcinoma. N Engl J Med 338: 297–306
Schlumberger MJ (Hrsg) (1999) RhTSH: New directions in detection and management of well-differentiated thyroid carcinoma. J Endocrinol Invest 22 (Suppl): 1–41
Schmitz A, Risse JH, Kälicke T, Grünwald F, Biersack HJ, Schmitt O (2000) FDG-PET zur Diagnostik und Verlaufskontrolle entzündlicher Prozesse: Erste Ergebnisse aus orthopädischer Sicht. Z Orthop 138: 407–412
Scott AM, Macapinlac H, Zhang J et al. (1995) Image registration of SPECT and CT images using an external fiduciary band and three-dimensional surface fitting in metastatic thyroid cancer. J Nucl Med 36: 100–103
Shah DH, Samuel AM (1996) Metastasis to the liver in well-differentiated carcinoma of the thyroid. Thyroid 6: 607–611
Shalaby-Rana E, Majd M, Andrich MP, Movassaghi N (1997) In-111 pentetreotide scintigraphy in patients with neuroblastoma. Comparison with 1–131 MIBG, N-Myc oncogene amplification, and patient outcome. Clin Nucl Med 22: 315–319
Siproudhis L, Lescouarch J, Bretagne JF et al. (1991) Contribution of 1311 MIBG scintigraphy in the diagnosis of carcinoid tumors of the digestive tract. Experience of 14 cases. Gastroenterol Clin Biol 15: 789–793
Smith MC, Liu J, Chen T et al. (2000) OctreoTher: Ongoing early clinical development of a somatostatin-receptor-targeted radionuclide antineoplastic therapy. Digestion 62 Suppl 1: 69–72
Sone T, Fukunaga M, Otsuka N et al. (1985) Metastatic medullary thyroid cancer: Localization with iodine-131 metaiodobenzylguanidine. J Nucl Med 26: 604–608
Troncone L, Rufini V(1998) Radiolabeled metaiodobenzylguanidine in the diagnosis of neural crest tumors. In: Murray IPC, Ell PJ (eds) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 843–857
Vitola JV, Delbeke D, Sandler MP et al. (1996a) Positron emission tomography to stage suspected metastatic colorectal carcinoma to the liver. Am J Surg 171: 21–26
Vitola JV, Delbeke D, Meranze SG, Mazer MJ, Pinson CW (1996b) Positron emission tomography with F-18-fluorodeoxyglucose to evaluate the results of hepatic chemoembolization. Cancer 78: 2216–2222
Vogl TJ, Trapp M, Schroeder H et al. (2000) Transarterial chemoembolization for hepatocellular carcinoma: Volumetrie and morphologic CT criteria for assessment of prognosis and therapeutic success results from a liver transplantation center. Radiology 214: 349–357
Wahl RL (1998) Positron emission tomography: Applications in oncology. In: Murray IPC, Ell PJ (Hrsg) Nuclear medicine in clinical diagnosis and treatment, 2nd edn. Churchill Livingstone, Edinburgh London New York, pp 911–940
Woolfenden JM, Waxman AD, Wolfstein RS, Siemsen JK (1975) Scintigraphic elvaluation of liver metastases from thyroid carcinoma. J Nucl Med 16: 669–671
Yasuda S, Makuuchi Y, Sadahiro S, Mukai M, Tokunaga N, Tajima T, Shohtsu A (1998) Colorectal cancer recurrence in the liver: Detection by PET. Tokai J Exp Clin Med 23: 167–171
Yonekura Y, Benua RS, Brill AB et al. (1982) Increased accumulation of 2-deoxy-2-[18F]Fluoro-D-glucose in liver metastases from colon carcinoma. J Nucl Med 23: 1133–1137
Zuetenhorst H, Taal BG, Boot H, Valdes Olmos R, Hoefnagel C (1999) Long-term palliation in metastatic carcinoid tumours with various applications of meta-iodobenzylguanidin (MIBG): Pharmacological MIBG, 1311-labelled MIBG andthe combination. Eur J Gastroenterol Hepatol 11: 1157–1164
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2002 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Risse, J.H., Grünwald, F. (2002). Nuklearmedizinische Diagnostik und Therapie von Lebermetastasen. In: Vogl, T.J., Mack, M.G., Balzer, J.O. (eds) LeberMetastasen. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59385-7_10
Download citation
DOI: https://doi.org/10.1007/978-3-642-59385-7_10
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-63958-6
Online ISBN: 978-3-642-59385-7
eBook Packages: Springer Book Archive