Zusammenfassung
Noch beim Heidelberger Kongress der Deutschen Gesellschaft für Neurochirurgie 1975 [31] gehörte die neurodestruktive Schmerztherapie zum häufig und selbstverständlich eingesetzten Arsenal der Schmerztherapie — mangels Alternativen, die seither in großer Vielfalt in die Schmerztherapie eingeführt wurden. In Deutschland gab es damals weder eine medikamentöse Therapie chronischer Schmerzen noch eine Psycho- und Verhaltenstherapie; Nervenblockaden, Stimulationsverfahren und Akupunktur standen am Anfang ihrer Verbreitung. Bei dem Kongress wurden in 17 Plenarvorträgen die Ergebnisse neurodestruktiver Verfahren der Schmerzbekämpfung dargestellt, von vielen Varianten der Trigeminusoperation bis zur Hypophysektomie und stereotaktischen Großhirnoperationen, nur 5 Vorträge befassten sich mit der im Jahr zuvor in Deutschland eingeführten Rückenmarkstimulation. Die Erfolgsraten von Chordotomien und Thalamotomien lagen bei 90 bis 99% „schmerzfreien“ Patienten, wobei sich diese Bewertung meistens auf den Entlassungsbefund stützte. Über Misserfolge wurde kaum berichtet.
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Literatur
Azkue JJ, Zimmermann M, Hsieh TF, Herdegen T (1998) Peripheral nerve insult induces NMDA receptor-mediated, delayed degeneration in spinal neurons. Eur J Neurosci 10: 2204–2206
Baron R (2000) Peripheral neuropathic pain: from mechanisms to symptoms. Clin J Pain 16 (Suppl): S12–20
Bennett GJ (1994) Animal models of neuropathic pain. In: Gebhart GF, Hammond DL, Jensen DS (eds) Proceedings of the 7th World Congress on Pain. Progress in pain research and management, vol 2. IASP, Seattle, pp 495–510
Blottner D, Baumgarten HG (1994) Neurotrophy and regeneration in vivo. Acta Anat (Basel) 150: 235–245
Brin MF (1997) Botulinum toxin: chemistry, pharmacology, toxicity and immunology. Muscle Nerve Suppl 6: 146–168
Cajal, Ramon y (1959) Degeneration and regeneration in the nervous system. Nachdruck der Ausgabe von 1928. Hafner, New York
Casey KL (2000) Concepts of pain mechanisms: the contribution of functional imaging of the brain. In: Sandkühler J, Bromm B, Gebhart GF (eds) Progress in brain research, vol. 129. Elsevier, Amsterdam, pp 277–287
Coderre TJ, Katz J, Vaccarino AL, Melzack R (1993) Contribution of central plasticity to pathological pain: review of clinical and experimental evidence. Pain 52: 259–285
Coward K, Plumpton C, Facer P, Birch R, Carlstedt T, Tate S, Bountra C, Anand P (2000) Immunolocalization of SNS/PN3 and NaN/SNS2 sodium channels in human pain states. Pain 85: 41–50
Devor M (1994) The pathophysiology of damaged peripheral nerves. In: Wall PD, Melzack R (eds) Textbook of pain, 3rd edn. Churchill Livingstone, Edinburgh London New York, pp 79–101
Dodt HU, Forke D, Zimmermann M (1983) Persisting selective block of unmyelinated fibers in cutaneous nerves of the cat by distilled water. Neurosci Lett 35: 203–207
Dodt HU, Strichartz GR, Zimmermann M (1983) Phenol solutions differentially block conduction in cutaneous nerve fibers of the cat. Neurosci Lett 42: 323–327
Empl M, Renaud S, Erne B, Fuhr P, Straube A, Schaeren-Wiemers N, Steck AJ (2001) TNF alpha expression in painful and nonpainful neuropathies. Neurology 56: 1371–1377
England JD, Happel LT, Kline DG, Gamboni F, Thouron CL, Liu ZP, Levinson SR (1996) Sodium channel accumulation in humans with painful neuromas. Neurology 47: 272–276
Fazakerley JK, Allsopp TE (2001) Programmed cell death in virus infections of the nervous system. In: Gosztonyi G (ed) The Mechanisms of Neuronal Damage in Virus Infections of the Nervous System. Current Topics in Microbiology and Immunology, vol. 253, Springer, Berlin, pp 95–119
Flor H, Elbert T, Knecht S, Wienbruch C, Pantev C, Birbaumer N, Larbig W, Taub E (1995) Phantom-pain as a perceptual correlate of cortical reorganization following arm amputation. Nature 375: 482–484
Foerster O (ed) (1927) Die Leitungsbahnen des Schmerzgefühls and die chirurgische Behandlung der Schmerzzustände. Urban & Schwarzenberg, Berl in Wien
Foster L, Clapp L, Erickson M, Jabbari B (2001) Botulinum toxin A and chronic low back pain: a randomized, double-blind study. Neurology 56: 1290–1293
Freund B, Schwartz M, Symington JM (2000) Botulinum toxin: new treatment for temporomandibular disorders. Br J Oral Maxillofac Surg 5: 466–471
Gillardon F, Klimaschewski L, Wickert H, Krajewski S, Reed JC, Zimmermann M (1996) Expression pattern of candidate cell death effector proteins Box, Bd-2, Bd-X, and c-Jun in sensory and motor neurons following sciatic nerve transection in the rat. Brain Res 739: 244–250
Hassler R (1960) Die zentralen Systeme des Schmerzes. Acta Neurochir (Wien) 8: 353–423
Herdegen T, Leah JD (1998) Inducible and constitutive transcription factors in the mammalian nervous system: control of gene expression by Jun, Fos and Krox, and CREBIATF proteins. Brain Res Rev. 28: 370–490
Huber AB, Schwab ME (2000) Nogo-A, a potent inhibitor of neurite outgrowth and regeneration. Biol Chem 381: 407–419
Jänig W (1993) Sympathikus and Schmerz: Ideen, Hypothesen, Modelle. Der Schmerz 7: 226–240
Jänig W, Schmidt RF (eds) (1992) Reflex sympathetic dystrophy: Pathophysiological mechanisms and clinical implications. VCH, Weinheim
Ji R-R, Woolf CL (2001) Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiology of Disease 8: 1–10
Karplus IP, Kreidl A (1925) Zur Kenntnis der Schmerzleitung im Rückenmark, II. Mitteilung. Pflügers Arch Ges Physiol 207: 134–139
Klumpp D, Zimmermann M (1980) Irreversible differential block of A- and C-fibres following local nerve heating in the cat. J Physiol (Lond) 298: 471–482
Mao J, Price CD, Mayer DJ (1995) Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain. Pain 61: 353–364
Penfield W, Boldrey E (1937) Somatic motor and sensory representation in the cerebral cortex of man as studied by electrical brain stimulation. Brain 60: 389
Penzholz H, Brock M, Hamer J, Klinger M, Spoerri O (eds) (1975) Brain Hypoxia Pain. Advances in Neurosurgery, vol 3. Springer, Heidelberg
Raciborska DA, Charlton MP (1999) Retention of cleaved synaptosome-associated protein of 25 kDa (SNAP-25) in neuromuscular junctions: a new hypothesis to explain persistence of botulinum A poisoning. Can J Physiol Pharmacol 9: 679–688
Rydh-Rinder M, Berge OG, Hokfelt T (2001) Antinociceptive effects after intrathecal administration of phosphodiester-, 2’-O-allyl-and C-5-propyne-modified antisense oligodeoxynucleotides targeting the NMDARI subunit in mouse. Brain Res Mol Brain Res 86: 23–33
Sandkühler J, Liu X-G (1998) Induction of long-term potentiation at spinal synapses by noxious stimulation or nerve injury. Eur J Neurosci 10: 2476–2480
Seltze Z, Wu T, Max MB, Diehl SR (2001) Mapping a gene for neuropathic pain-related behavior following peripheral neurectomy in the mouse. Pain 93: 101–106
Shir Y, Sheth R, Campbell JN, Raja SN, Seltzer Z (2001 a) Soy-containing diet suppresses chronic neuropathic sensory disorders in rats. Anesth Analg 92: 1029–1034
Siegfried J, Zimmermann M (eds) (1981) Phantom and Stump Pain. Springer, Heidelberg, PP 185
Sommer C, Petrausch S, Lindenlaub T, Toyka TV (1999) Neutralizing antibodies to interleukin 1-receptor reduce pain associated behavior in mice with experimental neuropathy. Neurosci Lett 270: 25–28
Sommer C, Schmidt C, George A (1998) Hyperalgesia in experimental neuropathy is dependent on the TNF receptor 1. Exp Neurol 151: 138–142
Sorkin LS, Doom CM (2000) Epineurial application of TNF elicits an acute mechanical hyperalgesia in the awake rat. J Peripher Nery Syst 5: 96–100
Stanton-Hicks M (2000) Complex regional pain syndrome (type I, RSD; type II, causalgia): controversies. Clin J Pain 16 (Suppl): S33–40. Review
Vanegas H, Schaible HG (2001) Prostaglandins and cyclooxygenases in the spinal cord. Prog. Neurobiol 64: 327–363. Review
Wall PD, Devor M, Inbal R, Scadding JW, Schonfeld D, Seltzer Z, Tomkiewicz MM (1979) Autotomy following peripheral nerve lesions: experimental anaesthesia dolorosa. Pain 7: 103–111
White DM, Zimmermann M (1988) The bradykinin-induced release of substance P from nerve fibre endings in the rat saphenous nerve neuroma is not related to electrophysiological excitation. Neurosci Lett 92: 108–113
Woolf CJ, Shortland P, Coggeshall, RE (1992) Peripheral nerve injury triggers central sprouting of myelinated afferents. Nature 355: 75–78
Xie Y, Zhang J, Petersen M, LaMotte RH (1995) Functional changes in dorsal root ganglion cells after chronic nerve constriction in the rat. J Neurophysiol 73: 1811–1820
Zaal MJW, Völker-Dieben HJ, D’Amaro J (2o0o) Risk and prognostic factors of postherpetic neuralgia and focal sensory denervation: a prospective evaluation in acute herpes zoster ophthalmicus. Clin J Pain 16: 345–351
Zimmermann M (1985) Functional characteristics of sensory fibres in regenerating cutaneous nerves. In: Delwaide PJ, Gorio A (eds) Clinical Neurophysiology in Peripheral Neuropathies. Elsevier, Amsterdam, pp 41–56
Zimmermann M (1991) Central nervous mechanisms modulating pain-related information: Do they become deficient after lesions of the peripheral or central nervous system? In: Casey KL (ed) Pain and Central Nervous System Disease: The Central Pain Syndrome. Raven Press, New York, pp 183–199
Zimmermann M (2001) Pathobiology of neuropathic pain. Eur J Pharmacol, in press
Zimmermann M, Herdegen T (1994) Control of gene transcription by Jun and Fos proteins in the nervous system–beneficial or harmful molecular mechanisms of neuronal response to noxious stimulation? Am Pain Soc J 3: 33–48
Zimmermann M, Herdegen T (1996) Plasticity of the nervous system at the systemic, cellular and molecular levels: a mechanism of chronic pain and hyperalgesia. In: Carli G, Zimmermann M (eds) Towards the Neurobiology of Chronic Pain. Progress in Brain Research, Vol. iio, Elsevier Science B.V., Amsterdam, pp 233–259
Zimmermann M, Koschorke GM (1987) Chemosensitivity of nerve sprouts in experimental neuroma of cutaneous nerves of the cat. In: Schmidt RF, Schaible H-G, VahleHinz C (eds) Fine afferent nerve fibers and pain. VCH Verlagsgesellschaft, Weinheim, pp 105–113
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Zimmermann, M. (2002). Physiologie und Pathophysiologie der neurodestruktiven Schmerztherapie. In: Hankemeier, U.B., Hildebrandt, J. (eds) Neurodestruktive Verfahren in der Schmerztherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59376-5_2
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