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Therapie des Zervixkarzinoms bei der älteren Frau

  • Conference paper
Gießener Gynäkologische Fortbildung 2001

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Zusammenfassung

Die Inzidenz des Zervixkarzinoms steigt kontinuierlich mit zunehmendem Alter bis zum 60. Lebensjahr. Danach zeigt sich keine weitere Zunahme [1]. Dagegen zeigt die altersspezifische Mortalitätsrate einen kontinuierlichen linearen Anstieg bis ins höchste Lebensalter [1] (Abb. 1). Die Diagnose Zervixkarzinom wird bei jüngeren Frauen häufiger im Frühstadium gestellt als bei älteren Frauen [2] (Abb. 2).

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Literatur

  1. Wingo PA, Ries LA, Giovino GA et al. (1999) Annual report to the nation on the status of cancer, 1973–1996, with a special section on lung cancer and tobacco smoking [see comments]. J Natl Cancer Inst 91: 675–690

    Article  PubMed  CAS  Google Scholar 

  2. Grover SA, Cook EF, Adam J, Coupai L, Goldman L (1989) Delayed diagnosis of gynecologic tumors in elderly women: relation to national medical practice patterns. Am J Med 86:151–157

    Article  PubMed  CAS  Google Scholar 

  3. Celentano DD, Klassen AC, Weisman CS, Rosen-shein NB (1988) Cervical cancer screening practices among older women: results from the Maryland Cervical Cancer Case-Control Study [see comments]. J Clin Epidemiol 41: 531–541

    Article  PubMed  CAS  Google Scholar 

  4. Matsuyama T, Inoue I, Tsukamoto N et al. (1984) Stage Ib, IIa, and IIb cervix cancer, postsurgical staging, and prognosis. Cancer 54: 3072–3077

    Article  PubMed  CAS  Google Scholar 

  5. Muylder X, Belanger R, Vauclair R, Audet-Lapointe P, Cormier A, Methot Y (1984) Value of lymphography in stage IB cancer of the uterine cervix. Am J Obstet Gynecol 148: 610–613

    PubMed  Google Scholar 

  6. Arimoto T (1993) Significance of computed tomography-measured volume in the prognosis of cervical carcinoma. Cancer 72: 2383–2388

    Article  PubMed  CAS  Google Scholar 

  7. Rutledge FN, Mitchell MF, Munsell M, Bass S, McGuffee V, Atkinson EN (1992) Youth as a prognostic factor in carcinoma of the cervix: a matched analysis. Gynecol Oncol 44:123–130

    Article  PubMed  CAS  Google Scholar 

  8. Peipert JF, Wells CK, Schwartz PE, Feinstein AR (1994) Prognostic value of clinical variables in invasive cervical cancer. Obstet Gynecol 84:746–751

    PubMed  CAS  Google Scholar 

  9. Jenkin RD, Stryker JA (1968) The influence of the blood pressure on survival in cancer of the cervix. Br J Radiol 41: 913–920

    Article  PubMed  CAS  Google Scholar 

  10. Pecorelli S, Benedet JL, Creasman WT, Shepherd JH, Petterson F (1998) FIGO annual report on the results of treatment in gynaecological cancer. Anonymous Milano, 23rd edn. J Epi Biostat 3:1–168

    Google Scholar 

  11. Alvarez RD, Soong SJ, Kinney WK et al. (1989) Identification of prognostic factors and risk groups in patients found to have nodal metastasis at the time of radical hysterectomy for early-stage squamous carcinoma of the cervix. Gynecol Oncol 35: 130–135

    Article  PubMed  CAS  Google Scholar 

  12. Cheng WF, Lee CN, Chu JS et al. (1999) Vascularity index as a novel parameter for the in vivo assessment of angiogenesis in patients with cervical carcinoma. Cancer 85: 651–657

    Article  PubMed  CAS  Google Scholar 

  13. Delgado G, Bundy B, Zaino R, Sevin BU, Creasman WT, Major F (1990) Prospective surgical-pathological study of disease-free interval in patients with stage IB squamous cell carcinoma of the cervix: a Gynecologic Oncology Group study. Gynecol Oncol 38: 352–357

    Article  PubMed  CAS  Google Scholar 

  14. Gerdin E, Cnattingius S, Johnson P, Pettersson B (1994) Prognostic factors and relapse patterns in early-stage cervical carcinoma after brachythera-py and radical hysterectomy. Gynecol Oncol 53: 314–319

    Article  PubMed  CAS  Google Scholar 

  15. Hopkins MP, Morley GW (1991) Stage IB squamous cell cancer of the cervix: clinicopathologic features related to survival. Am J Obstet Gynecol 164:1520–1527

    PubMed  CAS  Google Scholar 

  16. Rose BR, Thompson CH, Simpson JM et al. (1995) Human papillomavirus deoxyribonucleic acid as a prognostic indicator in early-stage cervical cancer: a possible role for type 18. Am J Obstet Gynecol 173: 1461–1468

    Article  PubMed  CAS  Google Scholar 

  17. Burger RA, Monk BJ, Kurosaki T et al. (1996) Human papillomavirus type 18: association with poor prognosis in early stage cervical cancer [see comments]. J Natl Cancer Inst 88:1361–1368

    Article  PubMed  CAS  Google Scholar 

  18. Gostout BS, Podratz KC, McGovern R, Persing DH (1998) Cervical cancer in older women: a molecular analysis of human papillomavirus types, HLA types, and p53 mutations. Am J Obstet Gynecol 179: 56–61

    Article  PubMed  CAS  Google Scholar 

  19. Samet J, Hunt WC, Key C, Humble CG, Goodwin JS (1986) Choice of cancer therapy varies with age of patient. JAMA 255: 3385–3390

    Article  PubMed  CAS  Google Scholar 

  20. Lawton FG, Hacker NF (1990) Surgery for invasive gynecologic cancer in the elderly female population. Obstet Gynecol 76: 287–289

    PubMed  CAS  Google Scholar 

  21. Fuchtner C, Manetta A, Walker JL, Emma D, Berman M, Disaia PJ (1992) Radical hysterectomy in the elderly patient: analysis of morbidity. Am J Obstet Gynecol 166: 593–597

    PubMed  CAS  Google Scholar 

  22. Thomas GM (1999) Improved treatment for cervical cancer — concurrent chemotherapy and radiotherapy [editorial; comment]. N Engl J Med 340:1198–1200

    Article  PubMed  CAS  Google Scholar 

  23. Barillot I, Horiot JC, Pigneux J et al. (1997) Carcinoma of the intact uterine cervix treated with radiotherapy alone: a French cooperative study: update and multivariate analysis of prognostics factors. Int J Radiat Oncol Biol Phys 38: 969–978

    Article  PubMed  CAS  Google Scholar 

  24. Logsdon MD, Eifel PJ (1999) Figo IIIB squamous cell carcinoma of the cervix: an analysis of prognostic factors emphasizing the balance between external beam and intracavitary radiation therapy. Int J Radiat Oncol Biol Phys 43: 763–775

    Article  PubMed  CAS  Google Scholar 

  25. Thigpen JT, Vance R, Puneky L, Khansur T (1995) Chemotherapy as a palliative treatment in carcinoma of the uterine cervix. Semin Oncol 22: 16–24

    PubMed  CAS  Google Scholar 

  26. Curtin J, Lewis JL, Hoskins W, Jones W, Mychal-czak B, Spriggs D (1995) Long-term follow-up of phase II trial of adjuvant chemotherapy and whole pelvic radiation therapy after radical hysterectomy and pelvic lymphadenectomy for high-risk patients with early cervical cancer. Gynecol Oncol 56: 118

    Google Scholar 

  27. Lahousen M, Haas J, Pickel H et al. (1999) Chemotherapy versus radiotherapy versus observation for high-risk cervical carcinoma after radical hysterectomy: A randomized, prospective, multi-center trial. Gynecol Oncol 99:196–201

    Article  Google Scholar 

  28. Lippman SM, Parkinson DR, Itri LM et al. (1992) 13-cis-retinoic acid and interferon alpha-2a: effective combination therapy for advanced squamous cell carcinoma of the skin [see comments]. J Natl Cancer Inst 84: 235–241

    Article  PubMed  CAS  Google Scholar 

  29. Welander CE, Homesley HD, Barrett RJ (1991) Combined interferon alfa and doxorubicin in the treatment of advanced cervical cancer. Am J Obstet Gynecol 165: 284–290

    PubMed  CAS  Google Scholar 

  30. Ciatto S, Pirtoli L, Cionini L (1980) Radiotherapy for postoperative failures of carcinoma of cervix uteru. Surg Gynecol Obstet 151: 621–624

    PubMed  CAS  Google Scholar 

  31. Matthews CM, Morris M, Burke TW, Gershenson DM, Wharton JT, Rutledge FN (1992) Pelvic exenteration in the elderly patient. Obstet Gynecol 79: 773–777

    PubMed  CAS  Google Scholar 

  32. Ansink A, de Barros Lopes A, Naik R, Monaghan JM (1996) Recurrent stage IB cervical carcinoma: evaluation of the effectiveness of routine follow up surveillance. Br J Obstet Gynaecol 103: 1156–1158

    Article  PubMed  CAS  Google Scholar 

  33. Kreienberg R (1998) Fortgeschrittene Stadien des invasiven Zervixkarzinoms. Onkologe 4:142–152

    Article  Google Scholar 

  34. Vidaurreta J (1999) Laparoscopic staging in locally advanced cervical carcinoma: anew possible philosophy? Gynecol Oncol 75(3): 366–371

    Article  PubMed  CAS  Google Scholar 

  35. Kamprath S, Possover M, Schneider A (2000) Laparoscopic sentinel lymph node detection in patients with cervical cancer. Am J Obstet Gynecol 182(6): 1648

    Article  PubMed  CAS  Google Scholar 

  36. Dargent D, Ansquer Y, Mathevet P (2000) Technical development and results of left extraperitoneal laparoscopic paraaortic lymphadenec-tomy for cervical cancer [in process citation]. Gynecol Oncol 77: 87–92

    Article  PubMed  CAS  Google Scholar 

  37. Possover M, Stober S, Plaul K, Schneider A (2000) Identification and preservation of the motoric innervation of the bladder in radical hysterectomy type III. Gynecol Oncol 79:154–157

    Article  PubMed  CAS  Google Scholar 

  38. Keys HM, Bundy BN, Stehman FB et al. (1999) Cis-platin, radiation, and adjuvant hysterectomy compared with radiation and adjuvant hysterectomy for bulky stage IB cervical carcinoma [see comments]. N Engl J Med 340: 1154–1161

    Article  PubMed  CAS  Google Scholar 

  39. Malur S, Krause N, Köhler C, Schneider A (2001) Sentinel lymph node detection in patients with cervical cancer. Gynecol Oncol 80, in press

    Google Scholar 

  40. Rose PG, Bundy BN, Watkins EB et al. (1999) Concurrent cisplatin-based radiotherapy and chemotherapy for locally advanced cervical cancer [see comments]. N Engl J Med 340:1144–1153

    Article  PubMed  CAS  Google Scholar 

  41. Morris M, Eifel PJ, Lu J et al. (1999) Pelvic radiation with concurrent chemotherapy compared with pelvic and para-aortic radiation for high-risk cervical cancer [see comments]. N Engl J Med 340:1137–1143

    Article  PubMed  CAS  Google Scholar 

  42. Whitney CW, Sause W, Bundy BN et al. (1999) Randomized comparison of fluorouracil plus cis-platin versus hydroxyurea as an adjunct to radiation therapy in stage IIB-IVA carcinoma of the cervix with negative para-aortic lymph nodes: a Gynecologic Oncology Group and Southwest Oncology Group study [see comments]. J Clin Oncol 17: 1339–1348

    PubMed  CAS  Google Scholar 

  43. Peters WA, Liu PY, Barrett RJ et al. (2000) Concurrent chemotherapy and pelvic radiation therapy compared with pelvic radiation therapy alone as adjuvant therapy after radical surgery in high-risk early-stage cancer of the cervix. J Clin Oncol 18:1606–1613

    PubMed  CAS  Google Scholar 

  44. Sardi JE, Giaroli A, Sananes C et al. (1997) Long-term follow up of the first randomized trial using neoadjuvant chemotherapy in stage Ib squamous carcinoma of the cervix: the final results. Gynecol Oncol 67: 61–69

    Article  PubMed  CAS  Google Scholar 

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Authors
  1. A. Schneider
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  2. C. Köhler
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  3. U. Endisch
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  4. K. Plaul
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Editor information

Editors and Affiliations

  1. der Justus-Liebig-Universität, Klinikstraße 32, 35392, Gießen, Germany

    Wolfgang Künzel (Gf. Direktor der Frauenklinik und Hebammenschule) (Gf. Direktor der Frauenklinik und Hebammenschule)

  2. Ltd. Oberarzt der Frauenklinik der Justus-Liebig-Universität, Klinikstraße 32, 35392, Gießen, Germany

    Michael Kirschbaum

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© 2002 Springer-Verlag Berlin Heidelberg

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Schneider, A., Köhler, C., Endisch, U., Plaul, K. (2002). Therapie des Zervixkarzinoms bei der älteren Frau. In: Künzel, W., Kirschbaum, M. (eds) Gießener Gynäkologische Fortbildung 2001. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59375-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-59375-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-41699-9

  • Online ISBN: 978-3-642-59375-8

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