Abstract
All living organisms are limited to a finite life span, and humans are no exception. As with any mechanical system, the cumulative debilitating effects of time, wear, and gravity result in an almost imperceptible gradual degradation in performance. All our tissues are susceptible to these effects, although some are more resistant than others. Skin and bone are perhaps the most resilient tissues, and both have an amazing capacity for healing and regeneration that is the foundation of much of modern reconstructive surgery. Although articular cartilage is subjected to some of the highest mechanical demands, its capacity for repair and regeneration is unfortunately extremely limited and it is often among the first tissues to manifest the effects of aging. Remarkably, this relatively fragile tissue is responsible for transmitting loads exceeding several times our body weight for an estimated billion cycles during the course of an average lifetime. It is not surprising that any disturbance of the normal anatomic and biomechanical relationships can result in an acceleration of this gradual degradation characteristic of aging.
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Paley, D. (2002). Consequences of Malalignment. In: Principles of Deformity Correction. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59373-4_13
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DOI: https://doi.org/10.1007/978-3-642-59373-4_13
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