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Myoglobinurien, Myositis ossificans, nutritiv-toxische und paraneoplatische Myopathien, Amyloidosen

  • J. M. Schröder

Zusammenfassung

Myoglobin im Urin weist auf eine schwere Muskelschädigung hin, deren morphologisches Substrat in der Regel aus mehr oder weniger zahlreichen segmentalen oder ausgedehnteren Einzelfasernekrosen (Rhabdomyolyse) besteht. Das Myoglobin (MG 17000) ist normalerweise in der I-Band-Region lokalisiert, kann aber unter pathologischen Bedingungen auch im erweiterten Lumen des inneren Membransystems und frei im Sarkoplasma zu finden sein (Kawai et al. 1991). Von dort wird es in den extrazellulären Raum abgegeben und als relativ kleines Molekül gut durch die Niere ausgeschieden; doch können übergroße Mengen an Myoglobin zu einer tubulären Insuffizienz führen.

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Literatur

  1. Adams R D (1975) Diseases of muscle. A study in pathology, 3rd edn. Harper & Row, New YorkGoogle Scholar
  2. Azmy A, Benstedt J P M, Eckstein H B (1979) Myositis ossificans progressiva. Z Kinderchir 26: 252–258Google Scholar
  3. Barohn R J, Jackson C E, Rogers S J, Ridings L W, McVey A L (1994) Prolonged paralysis due to nondepolarizing neuromuscular blocking agents and corticosteroids. Muscle Nerve 17: 647–654PubMedCrossRefGoogle Scholar
  4. Becker P E, Kiener F (1964) Myopathien. Thieme, StuttgartGoogle Scholar
  5. Clouston P D, Saper C B, Arbizu T, Johnston I, Lang B, Newsom-Davis J, Posner J B (1992) Paraneoplastic cerebellar degeneration. III. Cerebellar degeneration, cancer, and the Lambert-Eaton myasthenic syndrome. Neurology 42: 1944–1950Google Scholar
  6. Enzinger F M, Weiss S W (1995) Soft tissue tumors, 3rd edn. Mosby, St. LouisGoogle Scholar
  7. Faris A A, Reyes M G (1971) Reappraisal of alcoholic myopathy. Clinical and biopsy study on chronic alcoholics without muscle weakness or wasting. J Neurol Neurosurg Psychiatry 34: 86–92Google Scholar
  8. Feldman G, Li M, Martin S et al. (2000) Fibrodysplasia ossificans progressiva, a heritable disorder of severe heterotopic ossification, maps to human chromosome 4q27–31. Am J Hum Genet 66: 128–135PubMedCrossRefGoogle Scholar
  9. Glenner G G, Page D L (1976) Amyloid, amyloidosis, and amy- loidegenesis. In: Richter GW, Epstein MA (eds) International review of experimental pathology. Academic Press, New York, pp 1–92Google Scholar
  10. Juntunen J, Teravainen H, Eriksson K, Larsen A, Hillbom M (1979) Peripheral neuropathy and myopathy. An experimental study of rats on alcohol and variable dietary thiamine. Virchows Arch A 383: 241–252Google Scholar
  11. Kawai H, Sebe T, Nishino H, Nishida Y, Saito S (1991) Light and electron microscopic studies on localization of myoglobin in skeletal muscle cells in neuromuscular diseases. Muscle Nerve 14: 342–347PubMedCrossRefGoogle Scholar
  12. Lambert E H, Eaton L M, Rooke E D (1956) Defect of neuromuscular conduction associaated with malignant neoplasms. Am J Physiol 187: 612–613Google Scholar
  13. Lagier R, Cox J N (1975) Pseudomalignant myositis ossificans. A pathological study of eight cases. Hum Pathol 6: 653-665Google Scholar
  14. Lane R J, Mastaglia F L (1978) Drug-induced myopathies in man. Lancet 2: 562–566PubMedCrossRefGoogle Scholar
  15. Massa R, Carpenter S, Holland P, Karpati G (1992) Loss and renewal of thick myofilaments in glucocorticoid-treated rat soleus after denervation and reinnervation. Muscle Nerve 15: 1290–1298PubMedCrossRefGoogle Scholar
  16. Morozova-Roche L A, Zurdo J, Spencer A et al. (2000) Amyloid fibril formation and seeding by wild-type human lysozyme and its disease-related mutational variants. J Struct Biol 130: 339–351PubMedCrossRefGoogle Scholar
  17. Rosman N P, Schapiro M B, Haddow J E (1978) Muscle weak-ness caused by an iodine-deficient diet: investigation of a nutritional myopathy. J Neuropathol Exp Neurol 37: 192–211PubMedCrossRefGoogle Scholar
  18. Schröder J M (1982) Pathologie der Muskulatur. Springer, Berlin Heidelberg New YorkGoogle Scholar
  19. Schröder J M (1999) Pathologie peripherer Nerven. Springer, Berlin Heidelberg New York TokyoCrossRefGoogle Scholar
  20. Schröder J M, Bertram M, Schnabel R, Pfaff U (1992) Nuclear and mitochondrial changes of muscle fibers in AIDS after treatment with high doses of zidovudine. Acta Neuropathol 85: 39–47PubMedCrossRefGoogle Scholar
  21. Schröder J M, Kaldenbach T, Piroth W (1996) Nuclear and mitochondrial changes of co-cultivated spinal cord, spinal ganglia and muscle fibers following treatment with various doses of zidovudine. Acta Neuropathol (Berl) 92: 138–149CrossRefGoogle Scholar
  22. Shirahama T, Cohen AS (1967) High-resolution electron microscopic analysis of the amyloid fibril. J Cell Biol 33: 679–708PubMedCrossRefGoogle Scholar
  23. Shy G M, Silverstein I (1965) A study of the effects upon the motor unit by remote malignancy. Brain 88: 515–528PubMedCrossRefGoogle Scholar
  24. Spuler S, Emslie-Smith A, Engel A G (1998) Amyloid myopathy: an underdiagnosed entity. Ann Neurol 43: 719–728PubMedCrossRefGoogle Scholar
  25. Urich H, Wilkinson M (1970) Necrosis of muscle with carcinoma: myositis or myopathy? J Neurol Neurosurg Psychiatry 33: 398–407PubMedCrossRefGoogle Scholar

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© Springer-Verlag Berlin Heidelberg 2002

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  • J. M. Schröder

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