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Multiple Sklerose und verwandte Syndrome

  • H. Wiethölter

Zusammenfassung

Die von Charcot 1868 beschriebene Kleinhirntrias von Nystagmus, skandierender Sprache und Tremor als Charakteristikum der multiplen Sklerose (Syn.: Encephalomyelitis disseminata, Charcot-Krankheit) ist keineswegs der Hauptbefund. Statistiken an einer großen Zahl von Patienten ergaben Pyramidenbahnläsionen bei mehr als 90%, Visusstörungen bei etwa 60% und Augenmotilitätsstörungen (Doppelbilder) bei etwa 40%, Sensibilitätsstörungen bei 83%, Hirnstamm- und Kleinhirnstörungen bei 75%, Blasenstörungen bei 57%, Gangataxien bei ca. 50%, Dysarthrie bei etwa 20% (Weinshenker et al. 1989).

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Literatur

  1. Allen I V (1983) Hydrolytic enzymes in multiple sclerosis. In: Zimmerman H M (ed) Progress in neuropathology, vol. 5. Raven, New York, pp 1–17Google Scholar
  2. Compston A, Sadovnick A D (1992) Epidemiology and genetics of mutiple sclerosis. Curr Opinion Neurol Neurosurg 5: 175–181Google Scholar
  3. Compston A, Ebers G, Lassmann H, McDonald I, Matthews B, Wekerle H (1999) McAlpine’s multiple sclerosis. Churchill Livingstone, LondonGoogle Scholar
  4. Ebers G C, Kukay K, Bulman D E et al. (1996) A full genom search in multiple sclerosis. Nat Genet 13: 472–476PubMedCrossRefGoogle Scholar
  5. Fierz W (1989) Genetik und Immunologie. In: Kesselring J (Hrsg) Multiple Sklerose. Kohlhammer, Stuttgart, pp 44–67Google Scholar
  6. Fishman HR (1982) Multiple sclerosis: a new perspective on epidemiologic patterns. Neurology 32: 864–870Google Scholar
  7. Hayes G M, Woodroofe M N, Cuzner M L (1987) Microglia are the major cell type expressing MHC class II in human white matter. J Neurol Sci 80: 25–37PubMedCrossRefGoogle Scholar
  8. Kesselring J (Hrsg) (1993) Multiple Sklerose. Kohlhammer, StuttgartGoogle Scholar
  9. Lauer K (1994) Multiple sclerosis in the old world: the new old map. In: Firnhaber W, Lauer K (Hrsg) Multiple sclerosis in Europe. An epidemiological update. LTV, Darmstadt, pp 14–27Google Scholar
  10. Lucchinetti C, Brück W, Parisi J, (2000) Heterogeneity of multiple sclerosis lesions: Implications for the pathogenesis of demyelination. Ann Neurol 47: 707–717Google Scholar
  11. Marburg O (1906) Die sog. „akute multiple Sklerose“. Jhrb Psychiat Neurol 27: 211–312Google Scholar
  12. Matthews W B (ed) (1991) McAlpin’s multiple sclerosis. Churchill Livingstone, LondonGoogle Scholar
  13. Mendez M F, Pogacar S (1988) Malignant monophasic multiple sclerosis or „Marburg’s disease“. Neurology 38: 1153–1155PubMedGoogle Scholar
  14. Meyermann R M, Lampert P W, Korr H, Wekerle H (1987) The blood brain barrier - the strict border to lymphoid cells. In: Cervos-Navarro J, Ferszt R (eds) Stroke and microcirculation. Raven, New York, pp 289–296Google Scholar
  15. Miller D (1992) Wertigkeit der Kernspintomographie in der Diagnose der multiplen Sklerose. Therapiewoche 42: 15–21Google Scholar
  16. Mumford C J, Wood N W, Kellar-Wood H (1994) The British isles survey of multiple sclerosis in twins. Neurology 44: 11–15PubMedGoogle Scholar
  17. Poser S (1986) Multiple Sklerose. Wissenschaftliche Buchgesellschaft, DarmstadtGoogle Scholar
  18. Poser S, Kurztke J F (1991) Epidemiology of MS (letter). Neurology 41: 157–158PubMedGoogle Scholar
  19. Reddy E P, Sandberg-Wollheim M, Mettus R V et al. (1989) Amplification and molecular cloning of HTLV-1 sequences from DNA of multiple sclerosis patients. Science 243: 529–533PubMedCrossRefGoogle Scholar
  20. Sobel R A, Mitchell M E, Fondren G (1990) Intercellular adhesion molecule-1 (ICAM-1) in cellular immune reactions in the human central nervous system. Am J Pathol 136: 1309–1316PubMedGoogle Scholar
  21. Ter Meulen V (1988) Autoimmune reactions against myelin basic protein induced by corona and measles viruses. Ann NY Acad Sci 540: 202–209PubMedCrossRefGoogle Scholar
  22. Trapp B D, Peterson J, Ransohoff R M et al. (1998) Axonal transection in the lesions of multiple sclerosis. N Engl J Med 338: 278–285PubMedCrossRefGoogle Scholar
  23. Traugott U (1992) Pathologie und Immunpathologie von Läsionen infolge Multipler Sklerose. In: Schmidt R M (Hrsg) Multiple Sklerose - Epidemiologie, Diagnostik und Therapie. G. Fischer, Stuttgart, pp 248–271Google Scholar
  24. Weinshenker B C, Bass R, Rice G P A, (1989) The natural history of multiple sclerosis: a geographically based study. I. Clinical course and disability. Brain 112: 133–146Google Scholar
  25. Weller M, Stevens A, Sommer N et al. (1991) Monitoring of disease activity in multiple sclerosis by cerebrospinal fluid interleukin determination. In: Wiethölter H, Dichgans J, Mertin J (eds) Current concepts in multiple sclerosis. Excerpta medica, Amsterdam, pp 117–122Google Scholar

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© Springer-Verlag Berlin Heidelberg 2002

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  • H. Wiethölter

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