PEG Application in Clinical Cases of Canine Paraplegia

  • Richard Ben Borgens
Part of the Advances in Anatomy Embryology and Cell Biology book series (ADVSANAT, volume 171)


Given the positive results gained from studies of guinea pig, veterinary clinical trials of PEG injections as a treatment for severe acute canine paraplegia have just been completed in a joint clinical trial at the Schools of Veterinary Medicine at Purdue University and Texas A&M University. The investigative protocol was similar to that described for OFS studies described in Sect. 14.1. Following admission to the hospital and a standardized neurological examination, to set a baseline of functional and physiological deficits, PEG was administered intravenously as soon as possible to spinal-injured dogs before and after surgery. If a durotomy was necessary, during decompressive surgery PEG was also topically applied to the exposed lesion for 2 min, removed, and lavaged, as in the laboratory experiments discussed in Sect. 15.3 “Repairing a crush Injury with PEG.”


Triblock Copolymer Methylprednisolone Sodium Succinate Polypropylene Oxide Hydrophilic Surfactant Amphiphilic Triblock Copolymer 
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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Richard Ben Borgens
    • 1
    • 2
  1. 1.School of Veterinary MedicinePurdue UniversityWest LafayetteUSA
  2. 2.School of EngineeringPurdue UniversityUSA

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