PEG Application in Clinical Cases of Canine Paraplegia
Given the positive results gained from studies of guinea pig, veterinary clinical trials of PEG injections as a treatment for severe acute canine paraplegia have just been completed in a joint clinical trial at the Schools of Veterinary Medicine at Purdue University and Texas A&M University. The investigative protocol was similar to that described for OFS studies described in Sect. 14.1. Following admission to the hospital and a standardized neurological examination, to set a baseline of functional and physiological deficits, PEG was administered intravenously as soon as possible to spinal-injured dogs before and after surgery. If a durotomy was necessary, during decompressive surgery PEG was also topically applied to the exposed lesion for 2 min, removed, and lavaged, as in the laboratory experiments discussed in Sect. 15.3 “Repairing a crush Injury with PEG.”
KeywordsTriblock Copolymer Methylprednisolone Sodium Succinate Polypropylene Oxide Hydrophilic Surfactant Amphiphilic Triblock Copolymer
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