Sealing the Breach in Cell Membranes with Hydrophilic Polymers
I have discussed the concept of occult damage to neurons and axons — damage that is initially below the level of anatomical detection. This damage may be in response to stretch injury, mild mechanical insult, or the first stages of membrane disintegration precipitated by hypoxia, anoxia, glucose deprivation (i.e., ischemia) or a reperfusion injury. Here, I will focus on the problem posed by a larger breach in the membrane that can be detected with anatomical methods, and one that is not likely to be sealed by natural repair mechanisms of axons. Secondary axotomy is the likely result of the failure of natural sealing mechanisms.
KeywordsSpinal Cord Compound Action Potential Transection Plane Spinal Cord White Matter Compound Action Potential Amplitude
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