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Familiäre lymphatische und myeloische Neoplasien

  • Reiner Siebert
Chapter
Part of the Molekulare Medizin book series (MOLMED)

Zusammenfassung

Die molekularen Mechanismen, die in der Pathogenese sporadischer Tumoren des Blut bildenden Systems eine Rolle spielen, sind wie wohl bei keiner anderen Tumorentität erforscht. Im Gegensatz dazu ist über die genetischen Grundlagen für das familiäre Auftreten von myeloischen und lymphatischen Neoplasien bisher nur wenig bekannt. Erste systematische Zusammenstellungen von Familien mit Leukämien und Lymphomen wurden von Videbaek sowie Razis und Mitarbeitern bereits in den Jahren 1947 und 1959 publiziert. Die Analyse der genetischen Grundlagen solcher familiären Häufungen wurde aber lange durch das Fehlen eines weltweit einheitlichen und biologisch fundierten Klassifikationssystems für hämatologische Tumoren beeinträchtigt. Deshalb konnten pathogenetisch verwandte Neoplasien nur unzureichend als solche erkannt werden. Außerdem wurden in der Vergangenheit häufig klonale Erkrankungen der lymphatischen und der myleoischen Reihe unter dem Begriff „Leukämie“ subsumiert.

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© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Reiner Siebert

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