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Chronisch lymphatische Leukämie vom B-Zell-Typ (B-CLL)

  • Stephan Stilgenbauer
  • Hartmut Döhner
  • Peter Lichter
Chapter
Part of the Molekulare Medizin book series (MOLMED)

Zusammenfassung

Die chronisch lymphatische Leukämie vom B-Zell-Typ (B-CLL) ist mit einer Inzidenz von etwa 5 Fällen pro 100000 Einwohner im Jahr die häufigste Leukämieform des Erwachsenenalters in der westlichen Welt (Rozman u. Montserrat 1995, Zwiebel u. Cheson 1998). Die Erkrankung betrifft vorwiegend Personen im höheren Lebensalter, wobei etwa 20% der Patienten jünger als 55 Jahre sind (Mauro et al. 1999). Die CLL ist durch die Akkumulation morphologisch reif erscheinender, jedoch funktionell inkompetenter Lymphozyten in Knochenmark, Blut, Lymphknoten und anderen Organen vorwiegend des lymphatischen Systems charakterisiert (Abb. 4.1.1b). Im Verlauf der Krankheit kommt es zu einer zunehmenden Verdrängung der Hämatopoese und einer Beeinträchtigung der Organfunktionen mit der Folge von Allgemeinsymptomen, Lymphadenopathien (Abb. 4.1.1a), Infekt- und Blutungsneigung. Derzeit verfügbare konventionelle Therapieverfahren sind von palliativem Charakter.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Stephan Stilgenbauer
  • Hartmut Döhner
  • Peter Lichter

There are no affiliations available

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