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Nonhuman Primate Mhc-DP Genes

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Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates

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Abstract

The primate MHC class II region consists of six gene families, DP, DN, DM, DO, DQ, and DR, arranged respectively from centromere to telomere (Trowsdale et al. 1991). The DM, DP, DQ, and DR families each contain genes coding for the α- and β-chains of the class II molecules (the A and B genes, respectively), whereas in DN only one A gene and in DO only one B gene have thus far been identified. The MHC class II genes code for cell surface glycoprotein receptors which bind peptides derived from processed antigens and present them to helper T cells (Klein 1986; Bjorkman et al. 1990; Brown et al. 1993). The class II molecules exhibit differential tissue distribution; their constitutive expression is restricted primarily to cells of the immune system such as B cells, activated T lymphocytes, macrophages, and dendritic cells (Klein 1986).

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Authors
  1. B. Grahovac
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Editors and Affiliations

  1. Laboratoire d’Immunogénétique moléculaire, Université Paul Sabatier, CHU de Toulouse Hôpital Purpan, Place du Docteur Baylac, 31059, Toulouse cedex, France

    Antoine Blancher MD, PhD

  2. Max-Planck-Institut für Biologie Abteilung Immungenetik, Correnstr. 42, 72076, Tübingen, Germany

    Jan Klein PhD

  3. Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Fl, 33101, USA

    Jan Klein PhD

  4. Laboratory for Experimental Medicine and Surgery in Primates (LEMSIP), New York University Medical Center, 10 Townsend Avenue, Upper Grandview, NY, 10960-4830, USA

    Wladyslaw Socha MD

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© 1997 Springer-Verlag Berlin Heidelberg

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Grahovac, B. (1997). Nonhuman Primate Mhc-DP Genes. In: Blancher, A., Klein, J., Socha, W. (eds) Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59086-3_17

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  • DOI: https://doi.org/10.1007/978-3-642-59086-3_17

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63843-5

  • Online ISBN: 978-3-642-59086-3

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