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MHC Class I Genes in Nonhuman Primates

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Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates

Abstract

The primate order includes two suborders, the Prosimii and the Anthropoidea (Martin 1970). The Prosimii include tarsiers, lemurs and lorises whereas the Anthropoidea include two infraorders, Catarrhini and Platyrrhini. Catarrhini are Old World primates (for example, rhesus monkeys), apes (chimpanzees, gorillas, orangutans and gibbons) and humans. The taxonomic status of the 16 genera that form the infraorder Platyrrhini (commonly known as the New World primates) has been controversial. However, both morphological studies (Ford 1986; Kay 1990; Rosenberger 1984) and molecular data (Schneider et al. 1993) agree on dividing the 16 extant platyrrhine genera into seven phyletic groups: Callitrichidae (tamarins and marmosets (Fig.1); genera Callithrix, Cebuella, Leontopithecus, Saguinus and Callimico), Pithecinae (genera Pithecia, Chiropotes, and Cacajao),Atelinae (genera Lagothrix, Brachyteles, Ateles and Alouatta), genus Cebus, genus Saimiri (squirrel monkeys), genus Aotus (owl monkeys) and genus Callicebus.

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References

  • Balner H, van Leeuwen A, Dersjant H, van Rood JJ. Defined leukocyte antigens in chimpanzees: use of chimpanzee isoantisera for leukocyte typing in man. Transplantation 5: 624–2, 1967

    Article  PubMed  CAS  Google Scholar 

  • Balner H, van Vreeswijk W, Roger JH, D’amaro J. The major histocompatibility complex in chimpanzees: identification of several new antigens controlled by the the A and B loci of ChLA. Tissue Antigens 12: 1–18, 1978

    PubMed  CAS  Google Scholar 

  • Belich MP, Madrigal JA, Hidebrand WH, Zemmour J, Williams RC, Luz R, Petzl-Erler ML, Parham P. Unusual HLA-B alleles in two tribes of Brazilian Indians. Nature 357: 326–329, 1992

    Article  PubMed  CAS  Google Scholar 

  • Benirschke K, Anderson JM, Brownhill LC. Marrow chimerism in marmosets. Science 138: 513–515, 1962

    Article  PubMed  CAS  Google Scholar 

  • Boyson JE, Shufflebotham C, Cadavid LF, Urvater JA, Knapp LA, Hughes AL, and Watkins DI. The MHC Class I Genes of the Rhesus Monkey: Different Evolutionary Histories of MHC Class I and II Genes in Primates. J. Immunol. 156: 4656–4665, 1996a

    CAS  Google Scholar 

  • Boyson JE, Iwanaga KK, Golos TG, and Watkins DI. Identification of the Rhesus Monkey HLA-G Ortholog: Mamu-G is a Pseudogene. J. Immunol. 157: 5428–5437 1996b

    CAS  Google Scholar 

  • Boyson JE, McAdam SN, Gallimore A, Golos TG, Liu X, Gotch FM, Hughes AL, Watkins DI. The MHC E locus in macaques is polymorphic and is conserved between macaques and humans. Immunogenetics 41: 59–68, 1995

    Article  PubMed  CAS  Google Scholar 

  • Bruce EJ, Ayala FJ. Phylogenetic relationships between man and apes: electrophoretic evidence. Evolution 33: 1040–1052, 1979

    Article  Google Scholar 

  • Chang L-YE, Slightom JL. Isolation of and nucleotide sequence analysis of the b-type globin pseudogene from human, gorilla and chimpanzee. J Mol Evol 180: 767–784, 1984

    CAS  Google Scholar 

  • Chen ZW, McAdam SN, Hughes AL, Dogon AL, Letvin NL, Watkins DI. Molecular cloning of orangutan and gibbon MHC class I cDNA: the HLA-A and -B loci diverged over 30 million year ago. J Immunol 148: 2547–2554, 1992

    PubMed  CAS  Google Scholar 

  • Chen ZW, Hughes AL, Ghim SH, Letvin NL, Watkins DI. Two more chimpanzee Patr-A locus alleles related to the HLA-A1/A3/All family. Immunogenetics 38: 238–240, 1993

    Article  PubMed  CAS  Google Scholar 

  • Conroy GC. Primate evolution. Norton, New York, 1990

    Google Scholar 

  • Corell A, Morales P, Martinez-Laso J, Martin-Villa JM, Varela P, Paz-Artal E, Allende LM, Rodriguez C, Arniz-Villena A. New species-specific alleles at the primate MHC-G locus. Hum Immunol 41: 52–55, 1994

    Article  PubMed  CAS  Google Scholar 

  • Domena JD, Hildebrand WH, Bias WB, Parham P. A sixth family of HLA-A alleles defined by HLA-A*8001. Tissue Antigens 42: 156–159, 1993

    Article  PubMed  CAS  Google Scholar 

  • Dorf ME, Metzgar RS. Medical primatology. Proceedings of the 2nd conference on experimental medical surgery of primates. The distribution of human HLA-A antigens in chimpanzees and gorillas, New York, 1970

    Google Scholar 

  • Dover GA. Molecular drive: a cohesive mode of species evolution. Nature 299: 111–117, 1982

    Article  PubMed  CAS  Google Scholar 

  • Fan WM, Kasahara M, Gutknecht J, Klein D, Mayer WE, Jonker M, Klein J. Shared class II MHC polymorphism between humans and chimpanzees. Hum Immunol 26: 107–121, 1989

    Article  PubMed  CAS  Google Scholar 

  • Ferris SD, Brown WM, Davidson WS, Wilson AC. Extensive polimorphism in the mitochondria, DNA of apes. Proc Natl Acad Sci USA 78: 6319–6322, 1981

    Article  PubMed  CAS  Google Scholar 

  • Ford SM. Systematics of the New World Monkey. In: Swindler DR, Erwin J (eds) Comparative priamte biology, vol 1. Liss, New York, pp 73–135, 1986

    Google Scholar 

  • Gaur LK, Bowden DM, Tsai C-C, Davis A, Clark EA. The major histocompatibility complex MnLA of pigtailed macaques: definition of fifteen specificities. Hum Immunol 24: 277294, 1989

    Google Scholar 

  • Geraghty DE, Koller DH, Orr HT. A human histocompatibility complex class I gene that encodes a protein with a shortened cytoplasmic segment. Proc Natl Acad Sci USA 84: 9145–9149, 1987

    Article  PubMed  CAS  Google Scholar 

  • Goodman M. Molecular evolution in primates. In: Ehara TKA, Takenaka O, Iwamoto M (eds) Primatology today. Elsevier, New York, pp 11–18, 1991

    Google Scholar 

  • Heise ER, Cook DJ, Shepart BS, Manning CH, McMahan MR, Chedid M, Keever CA. The major histocompatibility complex of primates. Genetica 73: 53–68, 1987

    PubMed  CAS  Google Scholar 

  • Hershkovitz P. Living new world monkeys (platyrrhini) with an introduction to primates, vol 1. University of Chicago Press, Chicago, 1977

    Google Scholar 

  • Hoffstetter R. Un primate de l’Ologocene inferieour sudamericain:Branisella boliviana gen et sp nov. CR Acad Sci 69: 434–437 1969

    Google Scholar 

  • Hughes AL. Positive selection and interallelic recombination at the merozoite surface antigen-1 (MSA-i) locus of plasmodium. Mol Biol Evol 9: 381–393, 1992

    PubMed  CAS  Google Scholar 

  • Jukes TH, Cantor RC. Evolution of protein molecules. In: Munro HN (ed) Mammalia protein methabolism. Academic, New York, 1969

    Google Scholar 

  • Kay RF. The phyletic relationships of exatant and fossil pitheciinae (platyrrhini anthropoidea). J Hum Evol 19: 175–208, 1990

    Article  Google Scholar 

  • Keever CA, Heise ER. The major histocompatibility complex in cynomolgus monkeys: absorption of 24 CyLA antisera. Hum Immunol 12: 75–90, 1985a

    Article  CAS  Google Scholar 

  • Keever CA, Heise ER. The major histocompatibility complex in cynomolgus monkey. II. Polymorphism at three serologically defined loci and correlation of haplotypes with stimulation in MLC and skin graft survival. Hum Immunol 12: 143–164, 1985b

    Article  CAS  Google Scholar 

  • King MC, Wilson AC. Evolution at two levels in humans and chimpanzees. Science 188: 107–116, 1975

    Article  PubMed  CAS  Google Scholar 

  • Lawlor DA, Ward FE, Ennis PD, Jackson AP, Paharm P. HLA-A and HLA-B polymorphism predate the divergence of humans and chimpanzees. Nature 335: 268–271, 1988

    Article  PubMed  CAS  Google Scholar 

  • Lawlor DA, Warren E, Ward FE, Parham P. Comparision of class I MHC alleles in human and apes. Immunol Rev 113: 147–185, 1990

    Article  PubMed  CAS  Google Scholar 

  • Lawlor DA, Warren E, Taylor P, Parham P. Gorilla class I major histocompatibility complex alleles:comparision to human and chimpanzee class I. J Exp Med 174: 1491–1509, 1991

    Article  PubMed  CAS  Google Scholar 

  • Lawlor DA, Edelson BT, Parham P. MHC-A locus molecules in pygmy chimpanzees: conservation of peptide pockets. Immunogenetics 42: 291–295, 1995

    Article  PubMed  CAS  Google Scholar 

  • Lucotte G. Chimpanzees show less variation than man: electrophoretic evidence. J Hum Evol 12: 419–424, 1983

    Article  Google Scholar 

  • Martin RD. Primate origins and evolution: a phylogenetic reconstruction. Chapman and Hall, London, 1990

    Google Scholar 

  • Mayer WE, Jonker M, Klein D, Ivanyi P, van Seventer G, Klein J. Nucleotide sequences in chimpanzee MHC class I alleles: evidence for trans-species mode of evolution. EMBO J 7: 2765–2774, 1988

    PubMed  CAS  Google Scholar 

  • McAdam SN, Boyson JE, Liu X, Garber T, Hughes AL, Bontrop RE, Watkins DI. A uniquely high level of recombination at the HLA-B locus. Proc Natl Acad Sci USA 91: 5893–4897, 1994

    Article  PubMed  CAS  Google Scholar 

  • McAdam SN, Boyson JE, Liu X, Garber TL, Hughes AL, Bontrop RE. Watkins DI. Chimpanzee MHC class I A locus alleles are related to only one of the six families of human A locus alleles. J Immunol 154: 6421–6429, 1995

    PubMed  CAS  Google Scholar 

  • Miller MD, Yamamoto H, Hughes AL, Watkins DI, Letvin NL. Definition of an epitope and an MHC class I molecule recognized by gag-specific cytotoxic T-limphocytes in SIVmac-infected rhesus monkeys. J Immunol 147: 320–329, 1991

    PubMed  CAS  Google Scholar 

  • Miyamoto MM, Goodman M. DNA systematics and evolution in primates. Annu Rev Ecol Syst 21: 197–214, 1990

    Article  Google Scholar 

  • Miyamoto MM, Slightom JL, Goodman M. Phylogenetic relations of humans and African apes from DNA sequences in psi eta-globin region. Science 238: 369–373, 1987

    Article  PubMed  CAS  Google Scholar 

  • Otting N, Bontrop RE. Charactirization of the rhesus macaque (Macaca mulatta) equivalent of HLA-F. Immunogenetics 38: 141–145, 1993

    Article  PubMed  CAS  Google Scholar 

  • Parham P, Ploegh HL. Molecular characterization of HLA-A B homologues in owl monkeys and other nonhuman primates. Immunogenetics 11: 131–143, 1980

    Article  PubMed  CAS  Google Scholar 

  • Parham P, Lawlor DA, Lomen CE, Ennis PD. Diversity and diversification of HLA-A B C alleles. J Immunol 142: 3937–3950, 1989

    PubMed  CAS  Google Scholar 

  • Rada C, Lorenzini R, Powis SJ, van den Bogearde J, Parham P, Howard JC. Concerted evolution of class I genes in the major histocompatibility complex of murine rodents. Proc Natl Acad Sci USA 87: 2167–2171, 1990

    Article  PubMed  CAS  Google Scholar 

  • Rosemberger AL. Fossil new world monkeys dispute the molecular clock. J Hum Evol 13: 737–742, 1984

    Article  Google Scholar 

  • Rzhetsky A, Nei M. A simple method for estimating and testing minimun-evolution trees. Mol Biol Evol 9: 945–967, 1992

    CAS  Google Scholar 

  • Saitou N, Nei M. The neighbor joining method: a new method for reconstructiong phylogenetic trees. Mol Biol Evol 4: 406–425, 1986

    Google Scholar 

  • Schneider H, Schneider MPC, Sampaio I, Harada ML, Stanhope M, Czelusniak J, Goodman M. Molecular phylogeny of the new world monkeys (platyrrhini primates). Mol Phy Evol 2: 225–242, 1993

    Article  CAS  Google Scholar 

  • Simpson GG. Splendid isolation. Yale University Press, New Haven, 1980

    Google Scholar 

  • Smith KK, Parham P, Ma NSF. Two distinct forms of beta2-microglobulin in different races of owl monkey (Aotus trivirgatus). Immunogenetics 20: 459–464, 1984

    Article  PubMed  CAS  Google Scholar 

  • Smith NH, Beltran P, Selander RK. Recombination of salmonella phase 1 flagellin genes generates new serovars. J Bacteriol 172: 2209–2216, 1990

    PubMed  CAS  Google Scholar 

  • Starling GC, Witkowski JA, Speerbrecher LS, McKinney SK, Hansen JA, Choo SY. A novel HLA-A*8001 allele identified in an African-American population. Hum Immunol 39: 163–168, 1994

    Article  PubMed  CAS  Google Scholar 

  • Tamura K, Nai M. Stimation of the number of nucleotide substitutions in the control region of mitochondrial DNA in humans and chimpanzees. Mol Biol Evol 10: 512–526, 1993

    PubMed  CAS  Google Scholar 

  • Wagner AG, Hughes AL, Iandoli ML, Stewart D, Herbert S, Watkins DI, Hurly CK, Rosen-Brosen S. HLA-A*8001 a member of a newly discovered ancient family of HLA-A alleles. Tissue Antigens 42: 522–529, 1993

    Article  PubMed  CAS  Google Scholar 

  • Watanabe N, McAdam SN, Boyson JE, Piekarczyk MS, Yasutomi Y, Watkins DI, Letvin NL. A simian immunodeficiency virus envelope V3 cytotoxic T-lymphocyte epitope in rhesus monkey and its restricting major histocompatibility camplex class I molecule Mamu-A*02. J Virol 68: 6690–6696, 1994

    PubMed  CAS  Google Scholar 

  • Watkins DI, Kannagi M, Stone ME, Letvin NL. Major histocompatibility complex class I molecules of nonhuman primates. Eur J Immunol 18: 1425–1432, 1988a

    Article  CAS  Google Scholar 

  • Watkins DI, Hodi FS, Letvin NL. A primate species with limited major histocompatibility complex class I polymorphism. Proc Natl Acad Sci USA 85: 7714–7718, 1988b

    Article  CAS  Google Scholar 

  • Watkins DI, Letvin NI, Hughes AL, Tedder TE Molecular cloning of cDNA that encode MHC class I molecules from a new world primate (Saguinus oedipus): natural selection acts at points that may affect the peptide presentation to T cells. J Immunol 144: 1136–1143, 1990a

    CAS  Google Scholar 

  • Watkins DI, Chen ZW, Hughes AL, Evans MG, Tedder TF, Letvin NL. Evolution of MHC class I genes of a New World primate from ancestral homologues of human nonclassical genes. Nature 346: 60–63. 1990b

    Article  CAS  Google Scholar 

  • Watkins DI, Letvin NL Limited MHC polymorphism is not essential for bone marrow chimerism in New World primates. Immunogenetics 33: 194–197, 1991

    Article  PubMed  CAS  Google Scholar 

  • Watkins DI, Chen ZW, Garber TL, Hughes AL, Letvin NL. Segmental exchange between MHC class I genes in a higher primate:recombination in the gorilla between the ancestor of a human non-functional gene and an A locus gene. Immunogenetics 34: 185–191, 1991

    Article  PubMed  CAS  Google Scholar 

  • Watkins DI, McAdam SN, Liu X, Strang CR, Milford EL, Leviene CG, Garber TL, Dogon AL, Lord CI, Ghim SH, Troup GM, Hughes AL, Letvin NL. New recombinat HLA-B a tribe of South American Amerindians indicate rapid evolution of MHC class I loci. Nature 357: 329–333, 1992

    Article  PubMed  CAS  Google Scholar 

  • Wislocki GB. Observations on twinning marmosets. Am J Anat 64: 445–459, 1939

    Article  Google Scholar 

  • Yasutomi Y, McAdam SN, Boyson JE, Piekarczyk MS, Watkins ID, Letvin NL. A MHC class I B locus allele-restricted simian immunodeficiency virus envelope CTL epitope in rhesus monkey. J Immunol 154: 2516–2522, 1995

    PubMed  CAS  Google Scholar 

  • Zemmour J, Koller BH, Ennis PD, Geraghty DE, Lawlor DA, Orr HT, Parham P. HLA-AR an inactivated antigen-presenting locus related to HLA-A. J Immunol 144: 3619–3629, 1990

    PubMed  CAS  Google Scholar 

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Authors
  1. L. F. Cadavid
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  2. D. I. Watkins
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Editors and Affiliations

  1. Laboratoire d’Immunogénétique moléculaire, Université Paul Sabatier, CHU de Toulouse Hôpital Purpan, Place du Docteur Baylac, 31059, Toulouse cedex, France

    Antoine Blancher MD, PhD

  2. Max-Planck-Institut für Biologie Abteilung Immungenetik, Correnstr. 42, 72076, Tübingen, Germany

    Jan Klein PhD

  3. Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, Fl, 33101, USA

    Jan Klein PhD

  4. Laboratory for Experimental Medicine and Surgery in Primates (LEMSIP), New York University Medical Center, 10 Townsend Avenue, Upper Grandview, NY, 10960-4830, USA

    Wladyslaw Socha MD

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© 1997 Springer-Verlag Berlin Heidelberg

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Cadavid, L.F., Watkins, D.I. (1997). MHC Class I Genes in Nonhuman Primates. In: Blancher, A., Klein, J., Socha, W. (eds) Molecular Biology and Evolution of Blood Group and MHC Antigens in Primates. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59086-3_13

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  • DOI: https://doi.org/10.1007/978-3-642-59086-3_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63843-5

  • Online ISBN: 978-3-642-59086-3

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