Skip to main content

Physiologie und klinischer Ablauf der Pubertät

  • Chapter
  • 58 Accesses

Zusammenfassung

Mit dem Begriff Pubertät bezeichnet man den Lebensabschnitt, in dem sich das Kind zum erwachsenen Menschen entwickelt. Diese Phase der physiologischen Wachstums- und Differenzierungsvorgänge bestimmt das gesamte 2. Lebensjahrzehnt.

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   109.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   139.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  1. Adelman JP, Mason AJ, Hayflick JS, Seeburg PH (1986). Isolation of the gene and hypothalamic cDNA for the common presursor of gonadotropin-releasing hormone and prolactin-release-inhibiting factor in human and rat. Proc Natl Acad Sci USA 83: 179–183

    PubMed  CAS  Google Scholar 

  2. Albertsson-Wikland K, Rosberg S, Lannering B, Dunkel L, Selstam G, Norjavaara E. Twenty-four-hour profiles of luteinizing hormone, follicle-stimulating hormone, testosterone, and estradiol levels: A semilongitudinal study throughout puberty in healthy boys. J Clin Endocrinol Metab 1997; 82: 541–9

    PubMed  CAS  Google Scholar 

  3. Allen LS, Gorski RA (1992) Sexual orientation and the size of the anterior commissure in the human brain. Proc Natl Acad Sci USA 89: 7199–7202

    PubMed  CAS  Google Scholar 

  4. Aloi JA, Dalkin AC, Schwartz NB et al. (1995) Ovarian inhibin subunit gene expression: regulation by gonadotropins and estradiol. Endocrinology 136: 1227–1232

    PubMed  CAS  Google Scholar 

  5. Arslan M, Pohl CR, Plant TM (1988) DL-2-amino-5phosphonopentanoic acid, a specific N-methyl-Daspartic acis receptor antagonist, suppresses pulsatile LH release in the rat. Neuroendocrinology 47: 465–468

    PubMed  CAS  Google Scholar 

  6. Baccetti B, Burrini AG, Capitani S et al. (1993) Studies on varicocele. II. The inhibin secretion. J Submicrosc Cytol Pathol 25: 137–144

    PubMed  CAS  Google Scholar 

  7. Bagatell CJ, Heiman JR, Rivier JE, Bremner WJ (1994) Effects of endogenous testosterone and estradiol on sexual behavior in normal young men. J Clin Endocrinol Metab 78: 711–716

    PubMed  CAS  Google Scholar 

  8. Baien AH, Schachter ME, Montgomery D, Reid RW, Jacobs HS (1993) Polycystic ovaries are a common finding in untreated female to male transsexuals. Clin Endocrinol (Oxf) 38: 325–329

    Google Scholar 

  9. Balthazart J, Ball GF (1995) Sexual differentiation of brain and behavior in birds. Trends Endocrinol Metab 6: 21–29

    PubMed  CAS  Google Scholar 

  10. Balthazart J, Foidart A (1993) Brain aromatase and the control of male sexual behavior. J Steroid Biochem Mol Biol 44: 521–540

    PubMed  CAS  Google Scholar 

  11. Beck W, Wuttke W (1980) Diurnal variations of plasma luteinizing hormone, follicle-stimulating hormone, and prolactin in boys and girls from birth to puberty. J Clin Endocrinol Metab 50: 635–640

    PubMed  CAS  Google Scholar 

  12. Belgorosky A, Chahin S, Chaler E, Maceiras M, Rivarola MA (1996) Serum concentrations of follicle stimulating hormone and luteinizing hormone in normal girls and boys during prepuberty and at early puberty. J Endocrinol Invest 19: 88–91

    PubMed  CAS  Google Scholar 

  13. Bender BG, Harmon RJ, Linden MG, Robinson A (1995) Psychosocial adaptation of 39 adolescents with sex chromosome abnormalities. Pediatrics 96: 302–308

    PubMed  CAS  Google Scholar 

  14. Beyer C, Wozniak A, Hutchison JB (1993) Sex-specific aromatization of testosterone in mouse hypothalamic neurons. Neuroendocrinology 58: 673–681

    PubMed  CAS  Google Scholar 

  15. Biro FM, Lucky AW, Huster GA, Morrison JA (1995) Pubertal staging in boys. J Pediatr 127: 100–102

    PubMed  CAS  Google Scholar 

  16. Black SM, Kaplan SL, Bristow JD, Grumbach MM (1994) Nitric oxide synthesized by GnRH neurons is a mediator of N-methyl-D-aspartate (NMDA)-induced GnRH secretion. Endocrinology 135: 1709–1712

    PubMed  Google Scholar 

  17. Blos P (1983) Adoleszenz - eine psychoanalytische Interpretation. Klett-Cotta, Stuttgart

    Google Scholar 

  18. Boudou P, Chivot M, Vexiau P et al. (1994) Evidence for decreased androgen 5a-reduction in skin and liver of men with severe acne after 13-cis-retinoic acid treatment. J Clin Endocrinol Metab 78: 1064–1069

    PubMed  CAS  Google Scholar 

  19. Bourguignon J-P (1991) Growth and timing of puberty: reciprocal effects. Horm Res 36: 131–135

    PubMed  CAS  Google Scholar 

  20. Bourguignon J-P (1995) The neuroendocrinology of puberty. Growth Gen Horm 11 (3): 1–6

    Google Scholar 

  21. Bourguignon J-P, Gerard A, Mathieu J, Mathieu A, Franchimont P (1990) Maturation of the hypothalamic control of pulsatile gonadotropin-releasing hormone secretion at onset of puberty. I. Increased activation of N-methyl-D-aspartate receptors. Endocrinology 127: 873–881

    PubMed  CAS  Google Scholar 

  22. Bourguignon J-P, Gerard A, Gonzalez M-LA, Purnelle G, Franchimont P (1995) Endogenous glutamate involvement in pulsatile secretion of gonadotropin-releasing hormone: evidence from effect of glutamine and developmental changes. Endocrinology 136: 911–916

    PubMed  CAS  Google Scholar 

  23. Brennemann W, Klingmüller D, Eter N, Bidlingmaier F (1995) Immunoreactive inhibin concentrations in human gonads and adrenals during the first years of life. Horm Res 44: 115–120

    PubMed  CAS  Google Scholar 

  24. Bridges NA, Hindmarsh PC, Matthews DR, Brook CGD (1994) The effect of changing gonadotropin-releasing hormone pulse frequency on puberty. J Clin Endocrinol Metab 79: 841–847

    PubMed  CAS  Google Scholar 

  25. Bridges NA, Matthews DR, Hindmarsh PC, Brook CGD (1994) Changes in gonadotropin secretion during childhood and puberty. J Endocrinol 141: 169–176

    PubMed  CAS  Google Scholar 

  26. Carley KP, Valk TW, Kelch RP, Marshall JC (1981) Estimation of GnRH pulse amplitude during pubertal development. Pediatr Res 15: 157–160

    Google Scholar 

  27. Chen C-LC (1993) Inhibin and activin as paracrine/ autocrine factors. Endocrinology 132: 4–5

    PubMed  CAS  Google Scholar 

  28. Chowen JA, Busiguina S, Garcia-Segura LM (1995) Sexual dimorphism and sex steroid modulation of glial fibrillary acidic protein messenger RNA and immunoreactivity levels in the rat hypothalamus. Neuroscience 69: 519–532

    PubMed  CAS  Google Scholar 

  29. Clancy AN, Michael RP (1994) Effects of testosterone and aromatase inhibition on estrogen receptor-like immunoreactivity in male rat brain. Neuroendocrinology 59: 552–560

    PubMed  CAS  Google Scholar 

  30. Clancy AN, Zumpe D, Michael RP (1995) Intracerebral infusion of an aromatase inhibitor, sexual behavior and brain estrogen receptor-like immunoreactivity in intact male rats. Neuroendocrinology 61: 98–111

    PubMed  CAS  Google Scholar 

  31. Clayton RN (1989) Gonadotropin-releasing hormone: its actions and receptors. J Endocrinol 120: 11–16

    PubMed  CAS  Google Scholar 

  32. Cohen HN, Hay ID, Annesley TM et al. (1982) Serum immunoreactive melatonin in boys with delayed puberty. Clin Endocrinol (Oxf) 17: 517–521

    CAS  Google Scholar 

  33. Cuttler L, Rosenfield RL, Ehrmann DA et al. (1993) Maturation of gonadotropin and sex steroid responses to gonadotropin-releasing hormone agonist in males. J Clin Endocrinol Metab 76: 362–366

    PubMed  CAS  Google Scholar 

  34. Deridder CM, Thijssen JHH, Bruning PF, Van den Brande JL, Zonderland ML, Erich WBM (1992) Body fat mass, body fat distribution, and pubertal development: a longitudinal study of physical and hormonal sexual maturation of girls. J Clin Endocrinol Metab 75: 442–446

    CAS  Google Scholar 

  35. Döhler KD, New MI (1989) Sexualentwicklung. In: Hesch RD (Hrsg) Innere Medizin der Gegenwart, Bd Endokrinologie A. Urban & Schwarzenberg, München, S 501–512

    Google Scholar 

  36. Dunkel L, Alfthan H, Stenman U-H, Tapanainen P, Perheentupa J (1990) Pulsatile secretion of LH and FSH in prepubertal and early pubertal boys revealed by ultrasensitive time resolving immunofluorometric assays. Pediatr Res 27: 215–219

    PubMed  CAS  Google Scholar 

  37. El-Migdadi F, Gallant S, Brownie AC (1995) Sex differences in cytochromes oxidase and P 45011 in the rat adrenal cortex. Mol Cell Endocrinol 112: 185–194

    PubMed  CAS  Google Scholar 

  38. El-Migdadi F, Gallant S, Brownie AC (1995) Sex differences in the steroidogenic and respiratory electron transport chains in the rat adrenal cortex. Endocr Res 21: 109–114

    PubMed  CAS  Google Scholar 

  39. Emans SJ, Woods ER, Allred EN, Grace E (1994) Hymenal findings in adolescent women: impact of tampon use and consensual sexual activity. J Pediatr 125: 153–160

    PubMed  CAS  Google Scholar 

  40. Erickson GF, McLachlan RI, McClure N, Healy DL, Burger HG (1995) The ovary: basic principles and concepts; A. Physiology, B. Clinical. In: Felig P, Baxter JD, Frohman LA (eds) Endocrinology and metabolism. McGraw-Hill, New York London Milan Toronto Tokyo Sydney, pp 973–1052

    Google Scholar 

  41. Fiddes JC, Talmadge K (1984) Structure, expression, and evolution of the genes for human glycoprotein hormones. Rec Progr Horm Res 40: 43–78

    PubMed  CAS  Google Scholar 

  42. Findlay JK (1993) An update on the roles of inhibin, activin, and follistatin as local regulators of folliculoge-nesis. Biol Reprod 48: 15–23

    PubMed  CAS  Google Scholar 

  43. Forest MG (1990) Pituitary gonadotropin and sex steroid secretion during the first two years of life. In: Grumbach MM, Sizonenko PC, Aubert ML (eds) Con-trol of the onset of puberty. Williams & Wilkins, Baltimore, pp 451–478

    Google Scholar 

  44. Genazzani AR, Palumbo MA, De Micheroux AA et al. (1995) Evidence for a role for the neurosteroid allopregnanolone in the modulation of reproductive function in female rats. Eur J Endocrinol 133: 375–380

    PubMed  CAS  Google Scholar 

  45. Ghai K, Rosenfield RL (1994) Maturation of the normalpituitary-testicular axis, as assessed by gonadotropinreleasing hormone agonist challenge. J Clin Endocrinol Metab 78: 1336–1340

    PubMed  CAS  Google Scholar 

  46. Giusti M, Falivene MR, Carraro A, Cuttica CM, Valenti S, Giordano G (1995) The effect of non-steroidal anti-androgen flutamide on luteinizing hormone pulsatile secretion in male-to-female transsexual subjects. JEndocrinol Invest 18: 420–426

    CAS  Google Scholar 

  47. Godwin J, Crews D (1995) Sex differences in estrogen and progesterone receptor messenger ribonucleic acid regulation in the brain of little striped whiptail lizards. Neuroendocrinology 62 293–300

    PubMed  CAS  Google Scholar 

  48. Goji K, Tanikaze S (1993) Spontaneous gonadotropin and testosterone concentration profiles in prepubertal63. and pubertal boys: temporal relationship between luteinizing hormone and testosterone. Pediatr Res 34: 229–236

    PubMed  CAS  Google Scholar 

  49. Gorski RA (1993) Estradiol acts via the estrogen recep-tor in the sexual differentiation of the rat brain, but what does this complex do. Endocrinology 133: 431–432

    PubMed  CAS  Google Scholar 

  50. Grumbach MM, Kaplan SL (1990) The neuroendocrinology of human puberty: an ontogenetic perspective. In:z 65. Grumbach MM, Sizonenko PC, Aubert ML (eds) Control of the onset of puberty. Williams & Wilkins, Baltimore, pp 1–68

    Google Scholar 

  51. Grumbach MM, Styne DM (1992) Puberty: ontogeny, neuroendocrinology, physiology, and disorders. In: Wilson JD, Foster DW (eds) Williams textbook of endocrinology. WB Saunders, Philadelphia London Toronto, pp 1139–1221

    Google Scholar 

  52. Gunasegaram R, Loganath A, Peh KL, Ratnam SS (1995) Aromatization of [4–14C]testosterone to [14C]estradiol- 170 by testicular tissue from male-to-female transsexuals on estrogen therapy. Arch Androl 35: 127–133

    PubMed  CAS  Google Scholar 

  53. Hamer DH, Hu S, Magnuson V, Hu N, Pattatucci AML (1993) Male sexual orientation and genetic evidence. Science 262: 2063–2065

    Google Scholar 

  54. Hammond GL, Bocchinfuso WP (1996) Sex hormone-binding globulin: gene organization and structure fun-ction analyses. Horm Res 45: 197–201

    PubMed  CAS  Google Scholar 

  55. Hardelin JP, Levilliers J, Young J et al. (1993) Xp 22.3 deletions in isolated familial Kallmann’s syndrome. J Clin Endocrinol Metab 76: 827–831

    PubMed  CAS  Google Scholar 

  56. Healy E, Simpson N (1994) Fortnightly review: Acne vulgaris. BMJ 308: 831–833

    PubMed  CAS  Google Scholar 

  57. .Hee JP, MacNaughton J, Bangah M et al. (1993) Follicle-stimulating hormone induces dose-dependant stimulation of immunoreactive inhibin secretion during the follicular phase of the human menstrual cycle. J Clin Endocrinol Metab 76: 1340–1343

    PubMed  CAS  Google Scholar 

  58. Hu S-B, Nowak FV (1995) Sex-specific changes in pre-optic regulatory factor-1 and preoptic regulatory factor-2 mRNA expression in the rat brain during development. Endocrine 3: 421–424

    PubMed  CAS  Google Scholar 

  59. Hu S, Pattatucci AML, Patterson C et al. (1995) Linkage between sexual orientation and chromosome Xq28 in males but not in females. Nature Genet 11: 248–256

    PubMed  CAS  Google Scholar 

  60. Jackacki RI, Kelch RP, Sauder SE, Lloyd JS, Hopwood NJ, Marshall JC (1982) Pulsatile secretion of luteinizing hormone in children. J Clin Endocrinol Metab 55: 453–458

    Google Scholar 

  61. Juarez J, Corsi-Cabrera M, Del Río-Portilla I (1995) Effects of prenatal testosterone treatment on sex differences in the EEG activity of the rat. Brain Res 694: 21–28

    PubMed  CAS  Google Scholar 

  62. Kletter GB, Padmanabhan V, Brown MB, Reiter EO, Sizonenko PC, Beitins IZ (1993) Serum bioactive gonadotropins during male puberty: a longitudinal study. J Clin Endocrinol Metab 76: 432–438

    PubMed  CAS  Google Scholar 

  63. Krummen LA, Woodruff TK, DeGuzman G et al. (1993) Identification and characterization of binding proteins for inhibin and activin in human serum and follicular fluids. Endocrinology 132: 431–443

    PubMed  CAS  Google Scholar 

  64. : Kühnemann S, Brown TJ, Hochberg RB, MacLusky NJ (1994) Sex differences in the development of estrogen receptors in the rat brain. Horm Behav 28: 483–491

    PubMed  Google Scholar 

  65. Kühnemann S, Brown TJ, Hochberg RB, MacLusky NJ (1995) Sexual differentiation of estrogen receptor concentrations in the rat brain: effects of neonatal testosterone exposure. Brain Res 691: 229–234

    PubMed  Google Scholar 

  66. Kuhnle U, Bullinger M, Schwarz HP, Knorr D (1993) Partnership and sexuality in adult female patients with congenital adrenal hyperplasia. First results of a cross-sectional quality-of-life evaluation. J Steroid Biochem Mol Biol 45: 123–126

    PubMed  CAS  Google Scholar 

  67. Kuhn HE, Grumbach MM, Kaplan SL (1969) Changing sensivity of pubertal gonadal hypothalamic feedback mechanism in man. Science 166: 1012–1018

    Google Scholar 

  68. Kuljis RO, Advis JP (1989) Immunocytochemical and physiological evidence of a synapse between dopamine-and luteinizing hormone releasing hormone-containing neurons in the ewe median eminence. Endocrinology 124: 1579–1581

    PubMed  CAS  Google Scholar 

  69. Labhard A (1986) Clinical Endocrinology. Theory and praxis. Springer, Berlin Heidelberg New York

    Google Scholar 

  70. Largo RH, Prader A (1983) Pubertal development in Swiss boys. Helv Paediatr Acta 38: 211–228

    PubMed  CAS  Google Scholar 

  71. Largo RH, Prader A (1983) Pubertal development in Swiss girls. Helv Paediatr Acta 38: 229–243

    PubMed  CAS  Google Scholar 

  72. Largo RH, Prader A (1987) Somatische Pubertätsentwicklung bei Mädchen. Monatschr Kinderheilkd 135: 479–484

    CAS  Google Scholar 

  73. Leranth C, MacLusky NJ, Sakamoto H et al. (1985) Glu-tamic acid decarboxylase-containing axons synapse on LHRH-neurons in the rat medial preoptic area. Neuro-endocrinology 40: 536–539

    CAS  Google Scholar 

  74. Lisciotto CA, Morrell JI (1994) Sex differences in the distribution and projections of testosterone target neurons in the medial preoptic area and the bed nucleus of the stria terminalis of rats. Horm Behav 28: 492–502

    PubMed  CAS  Google Scholar 

  75. Lucky AW (1995) Hormonal correlates of acne and hirsutism. Am J Med 98 (Suppl) 1A: 89S–94S

    PubMed  CAS  Google Scholar 

  76. Mahachoklertwattana P, Sanchez J, Kaplan SL, Grumbach MM (1994) N-methyl-D-aspartate (NMDA) receptors mediate the release of gonadotropin-releasing hormone (GnRH) by NMDA in a hypothalamic GnRH neuronal cell line (GT1–1). Endocrinology 134: 1023–1030

    PubMed  CAS  Google Scholar 

  77. Malhotra A, Poon E, Tse W-Y, Pringle PJ, Hindmarsh PC, Brook CGD (1993) The effects of oxandrolone on the growth hormone and gonadal axes in boys with constitutional delay of growth and puberty. Clin Endocrinol (Oxf) 38: 393–398

    CAS  Google Scholar 

  78. Manasco PK, Umbach DM, Muly SM et al. (1995) Ontogeny of gonadotropin, testosterone, and inhibin secretion in normal boys through puberty based on overnight serial sampling. J Clin Endocrinol Metab 80: 2046–2052

    PubMed  CAS  Google Scholar 

  79. Maszak G, Becker K, Conway S (1995) The development of sexually dimorphic sensitivity to growth hormone (GH) feedback of the clonidine-induced GH surge in the rat. Neuroendocrinology 62: 301–307

    PubMed  CAS  Google Scholar 

  80. Matuszczyk JV, Larsson K (1995) Sexual preference and feminine and masculine sexual behavior of male rats prenatally exposed to antiandrogen or antiestrogen. Horm Behav 29: 191–206

    CAS  Google Scholar 

  81. Mauras N, Veldhuis JD, Rogol AD (1986) Role of endogenous opiates in pubertal maturation: opposing actions of naltrexone in prepubertal and late pubertal boys. J Clin Endocrinol Metab 62: 1256–1263

    PubMed  CAS  Google Scholar 

  82. Mauras N, Rogol AD, Haymond MW, Veldhuis JD (1996) Sex steroids, growth hormone, insulin-like growth factor-1: neuroendocrine and metabolic regulation in puberty. Horm Res 45: 74–80

    PubMed  CAS  Google Scholar 

  83. Mayo KE (1994) Inhibin and activin: molecular aspects of regulation and function. Trends Endocrinol Metab 5: 407–415

    PubMed  CAS  Google Scholar 

  84. McCormick CM, Smythe JW, Beers D (1994) Sex differences in type I corticosteroid receptor binding in selective brain areas of rats. Ann NY Acad Sci 746: 431–433

    PubMed  CAS  Google Scholar 

  85. Metzger DL, Kerrigan JR, Rogol AD (1994) Gonadal steroid hormone regulation of the somatotropic axis during puberty in humans: mechanisms of androgen and estrogen action. Trends Endocrinol Metab 5: 290–296

    PubMed  CAS  Google Scholar 

  86. Möcks P, Schmidt MH (1990) Die regelhafte Pubertät - psychologische and psychosoziale Aspekte. In: Burmeister W, Heimann G, Sitzmann FC (Hrsg) Jugendmedizin - Band 94 Bücherei des Pädiaters. Enke, Stuttgart, pp 11–21

    Google Scholar 

  87. Montano MM, Welshons WV, Vom Saal FS (1995) Free estradiol in serum and brain uptake of estradiol during fetal and neonatal sexual differentiation in female rats. Biol Reprod 53: 1198–1207

    PubMed  CAS  Google Scholar 

  88. Moodbidri SB, Garde SV, Sheth AR (1992) Inhibin: unity in diversity. Arch Androl 28: 149–157

    PubMed  CAS  Google Scholar 

  89. Panzica GC, Aste N, Viglietti-Panzica C, Ottinger MA (1995) Structural sex differences in the brain: influence of gonadal steroids and behavioral correlates. J Endocrinol Invest 18: 232–252

    PubMed  CAS  Google Scholar 

  90. Pattatucci AML, Hamer DH (1995) Development and familiality of sexual orientation in females. Behav Genet 25: 407–420

    PubMed  CAS  Google Scholar 

  91. Penny R, Olambiwonu NO, Frasier SD (1977) Episodic fluctuations of serum gonadotropins in pre-and postpubertal girls and boys. J Clin Endocrinol Metab 45: 307–312

    PubMed  CAS  Google Scholar 

  92. Perheentupa A, Bergendahl M, De Jong FH, Huhtaniemi I (1993) Differential regulation of FSH and inhibin gene expression and synthesis by testosterone in immature and mature male rats. J Endocrinol 137: 69–79

    PubMed  CAS  Google Scholar 

  93. Plant TM (1988) Puberty in primates. In: Knobil E, Neill JD (eds) The physiology of reproduction. Raven, New York, pp 1763–1788

    Google Scholar 

  94. Plant TM, Gay VL, Marshall GR et al. (1989) Puberty in monkeys is triggered by chemical stimulation of the hypothalamus. Proc Natl Acad Sci USA 86: 2506–2510

    PubMed  CAS  Google Scholar 

  95. Plymate SR, Paulsen CA, McLachlan RI (1992) Relationship of serum inhibin levels to serum follicle stimulating hormone and sperm production in normal men and men with varicoceles. J Clin Endocrinol Metab 74: 859–864

    PubMed  CAS  Google Scholar 

  96. Pool R (1993) Evidence for homosexuality gene. Science 261: 291–292

    PubMed  CAS  Google Scholar 

  97. Prader A, Largo RH, Wolf C (1984) Timing of pubertal growth and maturation in the first Zurich longitudinal growth study. Acta Paediatr Hung 25: 155–159

    PubMed  CAS  Google Scholar 

  98. Prader A, Largo RH, Molinari L, Issler C (1989) Physical growth of Swiss children from birth to 20 years of age - first Zurich longitudinal study of growth and development. Helv Paediatr Acta (Suppl) 52: 1–125

    CAS  Google Scholar 

  99. Reite M, Sheeder J, Teale P, Richardson D, Adams M, Simon J (1995) Meg based brain laterality: sex differences in normal adults. Neuropsychologia 33: 1607–1613

    PubMed  CAS  Google Scholar 

  100. Reiter RJ (1980) The pineal and its hormones in the control of reproduction in mammals. Endocr Rev 1:109–131

    PubMed  CAS  Google Scholar 

  101. Relkin R (1983) The pineal gland. In: Relkin R (ed) Current endocrinology. Elsevier, New York, pp 121–163

    Google Scholar 

  102. Roberts VJ, Peto CA, Vale W, Sawchenko PE (1992) Inhibin/activin subunits are costored with FSH and LH in secretory granules of the rat anterior pituitary gland. Neuroendocrinology 56: 214–224

    PubMed  CAS  Google Scholar 

  103. Robertson DM, Sullivan J, Watson M, Cahir N (1995) Inhibin forms in human plasma. J Endocrinol 144: 261–269

    PubMed  CAS  Google Scholar 

  104. Roelfsema F, Van den Berg G, Frölich M et al. (1993) Sex-dependent alteration in cortisol response to endogenous adrenocorticotropin. J Clin Endocrinol Metab 77: 234–240

    PubMed  CAS  Google Scholar 

  105. Roselli CE, Resko JA (1993) Aromatase activity in the rat brain: hormonal regulation and sex differences. J Steroid Biochem Mol Biol 44: 499–508

    PubMed  CAS  Google Scholar 

  106. Ruf KB (1973) How does the brain control the process of puberty? J Neurol 204: 95–101

    CAS  Google Scholar 

  107. Santen RJ (1995) The testis. In: Felig P, Baxter JD, Froh-man LA (eds) Endocrinology and metabolism. McGraw-Hill, New York London Milan Tokyo Sydney Toronto, pp 885–972

    Google Scholar 

  108. Schwanzel-Fuduka M, Bick MD, Pfaff DW (1989) Luteinizing hormone-releasing hormone (LHRH)- expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome. Mol Brain Res 6: 311–326

    Google Scholar 

  109. Sholl SA, Goy RW, Kim KL (1989) 5-alpha-reductase, aromatase, and androgen receptor levels in the monkey brain during fetal development. Endocrinology 124: 627–634

    PubMed  CAS  Google Scholar 

  110. Spiteri-Grech J, Nieschlag E (1992) The role of growth hormone and insulin-like growth factor I in the regulation of male reproductive function. Horm Res 38 (Suppl 1):22–27

    PubMed  CAS  Google Scholar 

  111. Stolecke H (1987) Klinische und endokrinologische Merkmale der weiblichen Pubertät. In: Stolecke H, Terruhn V (Hrsg) Pädiatrische Gynäkologie. Springer, Berlin Heidelberg New York, S 83–103

    Google Scholar 

  112. Stolecke H (1990) Spezielle klinische Probleme - Abschn. 3.1: Akne. In: Burmeister W, Heimann G, Sitzmann FC (Hrsg) Jugendmedizin; Bd 94 Bücherei des Pädiaters. Enke, Stuttgart, S 26–27

    Google Scholar 

  113. Stolecke H (1990) Die regelhafte Pubertät, Abschn. 1.2: Klinischer Ablauf der Reifeentwicklung. In: Burmeister W, Heimann C, Sitzmann FC (Hrsg) Jugendmedizin; Bd 94 Bücherei des Pädiaters. Enke, Stuttgart, S 1–21

    Google Scholar 

  114. Stolecke H, Terruhn V (Hrsg) (1987) Pädiatrische Gynäkologie. Springer, Berlin Heidelberg New York

    Google Scholar 

  115. Stolecke H (1997) Progression der geschlechtsspezifischen Entwicklung. In: Ranke MB, Stolecke H: Pubertätsentwicklung. Dokument + Bild, Ankum-Kettenkamp, p. 19–35

    Google Scholar 

  116. Tanner JM (1973) Trend toward earlier menarche in London, Oslo, Copenhagen, The Netherlands and Hungary. Nature 243: 95–97

    PubMed  CAS  Google Scholar 

  117. Tanner JM, Eveleth PB (1975) Changes at age in menarche in Scandinavian countries, 1840–1978. In: Berenberg SR (ed) Puberty, biologic and psychosocial components. HE Stenfert Krose, Leiden, pp 256

    Google Scholar 

  118. Thind KK, Goldsmith PC (1988) Infundibular gonadotropin releasing hormone neurons are inhibited by direct opioid and autoregulatory synapses in juvenile monkeys. Neuroendocrinology 47: 203–216

    PubMed  CAS  Google Scholar 

  119. Thorner MO, Vance ML, Horvath E, Kovacs K (1992) The anterior pituitary. In: Wilson JD, Foster DW (eds) Williams textbook of endocrinology. WB Saunders, Philadelphia London Toronto Sydney Tokyo, pp 221–310

    Google Scholar 

  120. Tilbrook AJ, De Kretser DM, Clarke IJ (1993) Human recombinant inhibin A and testosterone act directly at the pituitary to suppress plasma concentrations of FSH in castrated rams. J Endocrinol 138: 181–189

    PubMed  CAS  Google Scholar 

  121. Travers SH, Jeffers BW, Bloch CA, Hill JO, Eckel RH (1995) Gender and Tanner stage differences in body composition and insulin sensitivity in early pubertal children. J Clin Endocrinol Metab 80: 172–178

    PubMed  CAS  Google Scholar 

  122. VanFurth WR, Wolterink G, Van Ree JM (1995) Regulation of masculine sexual behavior: involvement of brain opioids and dopamine. Brain Res Rev 21: 162–184

    PubMed  Google Scholar 

  123. VanWayjen RGA, Van den Ende A (1995) Experience in the long-term treatment of patients with hirsutism and/ or acne with cyproterone acetate-containing preparations: efficacy, metabolic and endocrine effects. Exp Clin Endocrinol Diabetes 103: 241–251

    PubMed  Google Scholar 

  124. Vaughan GM, Meyer GG, Reiter RJ (1978) Evidence for a pineal-gonadal relationship. In: Reiter RJ (ed) The pineal and reproduction. Karger, Basel, pp 191–233

    Google Scholar 

  125. Vieira JGH, Nishida SK, Pereira AB, Arraes RF, Verreschi ITN (1994) Serum levels of prostate-specific antigen in normal boys throughout puberty. J Clin Endocrinol Metab 78: 1185–1187

    PubMed  CAS  Google Scholar 

  126. Warkins PC, Eddy R, Beck AK et al. (1987) DNA sequence and regional assignment of the human follicle-stimulating hormone 3-subunit gene to the short arm of human chromosome 11. DNAcid 6: 205–212

    Google Scholar 

  127. Weissberger AJ, Ho KKY (1993) Activation of the somatotropic axis by testosterone in adult males: evidence for the role of aromatization. J Clin Endocrinol Metab 76: 1407–1412

    PubMed  CAS  Google Scholar 

  128. Wu FCW, Brown DC, Butler GE, Stirling HF, Kelnar CJH (1993) Early morning plasma testosterone is an accurate predictor of imminent pubertal development in prepubertal boys. J Clin Endocrinol Metab 76: 26–31

    PubMed  CAS  Google Scholar 

  129. Yahr P, Greene SB (1992) Effects of unilateral hypothalamic manipulations on the sexual behaviors of rats. Behav Neurosci 106: 698–709

    PubMed  CAS  Google Scholar 

  130. Zacharias LM, Rand M, Wurtman R (1976) A prospective study of sexual development in American girls: the statistics of menarche. Obstet Gynecol Sury 31: 325–337

    CAS  Google Scholar 

  131. Zhou JN, Hofman MA, Gooren LJG, Swaab DF (1995) A sex difference in the human brain and its relation to transsexuality. Nature 378: 68–70

    PubMed  CAS  Google Scholar 

  132. Ziegler NI von, Lichtensteiger W (1992) Asymmetry of brain aromatase activity: region-and sex-specific developmental patterns. Neuroendocrinology 55: 512–518

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1997 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Stolecke, H. (1997). Physiologie und klinischer Ablauf der Pubertät. In: Stolecke, H. (eds) Endokrinologie des Kindes- und Jugendalters. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59043-6_14

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-59043-6_14

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-61855-3

  • Online ISBN: 978-3-642-59043-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics