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Role of Nitric Oxide on Emotional and Motor Behaviour

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Neural Circuits and Networks

Part of the book series: NATO ASI Series ((NATO ASI F,volume 167))

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Abstract

Nitric Oxide (NO) has been proposed as a new neurotransmitter/neuromodulator in the Central Nervous System (CNS). Microinjections of inhibitors of NO synthase (NOS) the enzyme responsible for NO formation into the dorsal central grey induce anxiolytic effects in rats. On the other hand SIN-1 a NO donor microinjected into these regions induces flight reactions. However although systemic injections of low doses of NOS inhibitors induce anxiolytic effects in the elevated plus maze higher doses decrease maze exploration. This may involve motor effects of this compounds since we showed that they can induce catalepsy in a dose dependent manner in rodents either after systemic or Intra-striatal injections. These results suggest that NO may be related to the control of motor and emotional behaviour.

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Author information

Authors and Affiliations

  1. Depts. of Physiology, FORP, Ribeirão Preto, SP, 14049-900, Brazil

    E. A. Del Bel

  2. Depts of Pharmacology, FMRP Campus USP, Ribeirão Preto,SP, 14049-900, Brazil

    R. M. W. de Oliveira & F. S. Guimarães

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  1. E. A. Del Bel
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  2. R. M. W. de Oliveira
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  3. F. S. Guimarães
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Editors and Affiliations

  1. International School for Advanced Studies ISAS, Via Beirut n. 2-4, I-34013, Trieste, Italy

    Vincent Torre  & John Nicholls  & 

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Del Bel, E.A., de Oliveira, R.M.W., Guimarães, F.S. (1998). Role of Nitric Oxide on Emotional and Motor Behaviour. In: Torre, V., Nicholls, J. (eds) Neural Circuits and Networks. NATO ASI Series, vol 167. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58955-3_8

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  • DOI: https://doi.org/10.1007/978-3-642-58955-3_8

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63801-5

  • Online ISBN: 978-3-642-58955-3

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