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New HLA Typing Methods

  • Chapter
New Diagnostic Methods in Oncology and Hematology

Abstract

The human major histocompatibility complex (MHC) was discovered during studies initiated by J. Dausset, R. Payne and J. J. van Rood describing a genetically inherited system of alloantigens [1–3]. Initially histocompatibility research generated little interest among biologists, primarily because of the artificial nature of the underlying phenomenon, that is, rejection of organ transplants. Later, however, the MHC attracted a great deal of attention, and this as a result of immunological research, which demonstrated that histocompatibility molecules restrict the specificity of the antigen receptor expressed on the surface of T lymphocytes, and thus play a major role in the regulation of the immune response [4].

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  1. R. Blasczyk
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  1. Universitätsklinikum Charité Medizinische Fakultät, Humboldt-Universität zu Berlin, Augustenburger Platz 1, D-13353, Berlin, Germany

    Dieter Huhn

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Blasczyk, R. (1998). New HLA Typing Methods. In: Huhn, D. (eds) New Diagnostic Methods in Oncology and Hematology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58803-7_5

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