Skip to main content

Alfentanil und Remifentanil in der Kinderanästhesie

  • Conference paper
Neue Pharmaka und Techniken in der Kinderanästhesie

Part of the book series: Kinderanästhesie ((KINDERANAESTHES))

  • 30 Accesses

Zusammenfassung

Fentanyl war das erste einer Reihe von 4 Anilinopiperidin-Opiatagonisten und wurde in den 60er Jahren als im Vergleich zu Morphin 80mal potenteres Analgetikum in die Klinik eingeführt. 1983 wurde dann Alfentanil vorgestellt. Verglichen mit Fentanyl zeichnet es sich durch eine schnellere Anschlagzeit und eine kürzere Wirkdauer aus. Aufgrund seiner pharmakokinetischen und pharmakodynamischen Eigenschaften konnte es sich schnell in der Erwachsenenanästhesie etablieren.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 54.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 69.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literatur

  • Ausems ME, Hug CC, Sitanski DR, Burn AGL (1986) Plasmaconcentrations of alfentanil required to supplement nitrous oxide anesthesia for general surgery. Anesthesiology 65: 362–373

    Article  PubMed  CAS  Google Scholar 

  • Comstock MK, Scamman FL, Carter JG (1979) Rigidity and hypercarbia on fentanyl-oxygen induction. Anesthesiology 51: 28

    Article  Google Scholar 

  • Davis PJ, Killian A, Stiller RC, Cook DR, Guthrie RD, Scierka AM (1989) Pharmacokinetics of alfentanil in newborn premature infants and older children. Develop Pharmacol Ther 13: 21–27

    CAS  Google Scholar 

  • Davis PJ, Ross A, Stiller RL et al. (1995) Pharmacokinetics of remifentanil in anesthetized children 2–12 years of age. Anesth Analg 80: 93

    Article  Google Scholar 

  • De Castro J (1971) Association des analgesiques centraux et des neuroleptiques en cours d’intervention. In: Vourch G, De Castro J, Gauthier-Lafaye P, Guidi-cell JF, Viars P (eds) Les analgesiques et la douleur. Influences pharmacologiques diverses exerces sur morphiniques. Masson, Paris, pp 185–194

    Google Scholar 

  • Dershwitz M, Randel G, Rosow CE et al. (1992) Dose-response relationship of G187084B, a new ultra-short-acting opioid. Anesthesiology 77: A396

    Article  Google Scholar 

  • Eagan TD, Minto C, Lemmens HJM, Muir KT, Hermann DJ, Shafer SL (1994) Remifantil vs. Alfentanil: comparative pharmacokinetics. Anesthesiology 81: A373

    Article  Google Scholar 

  • Florez J, Mediavilla A (1978) Respiratory and cardiovascular effects of metenkephalin applied to the ventral surface of the brain stem. Brain Res 138: 585–590

    Article  Google Scholar 

  • Freye E, Hartung E, Buhl R (1986) Die Lungencompliance wird beim Menschen durch die rasche Injektion von Alfentanil beeinträchtigt. Anästhesist 35: 543–546

    CAS  Google Scholar 

  • Freye E (1995) Opioide in der Medizin. Springer, Berlin Heidelberg New York Tokio

    Google Scholar 

  • Frink EJ, Silverman ES, Azri BR, Brown BR (1989) Halothane, enflurane and isoflurane induced alterations of sufentanil metabolism in rat liver slices. Anesthesiology 71: A237

    Article  Google Scholar 

  • Glass PS, Hardman D, Kamiyama Y et al. (1993) Preliminary pharmacokinetics and pharmacodynamics of an ultra-short-acting opioid: remifentanil (G187084B). Anesth Analg 77: 1031–1040

    Article  PubMed  CAS  Google Scholar 

  • Helmers JH, Noorduin H, Adam AA, Giezen J, Leeuwen L van (1983) Anaesthesia with alfentanil in the geriatric patient. Anästhesist 32: 228–229

    Google Scholar 

  • Hermann DJ, Marton JP, Donn KH et al. (1991) Pharmacokinetic comparison of G187084B, a novel ultra-short acting opioid, and alfentanil. Anesthesiology 75: A379

    Article  Google Scholar 

  • Hill AB, Nahrwold ML, Rosayro M de, Knight PR, Jones RM, Bollen RE (1981) Prevention of Rigidity during fentanyl-oxygen induction of anesthesia. Anesthesiology 55: 452–454

    Article  PubMed  CAS  Google Scholar 

  • Hiller A (1993) Comparison of cardiovascular changes during anaesthesia and recovery from propofol-alfentanil-nitrous oxide and thiopentone-halothane-nitrous oxide anaesthesia in children undergoing otolaryngological surgery. Acta Anaesthesiol Scand 37: 737–741

    Article  PubMed  CAS  Google Scholar 

  • Hiller A, Klemola UM, Saarnivaara L (1993) Tracheal intubation after induction of anaesthasia with propofol, alfentanil and lidocaine without neuromuscular blocking drugs in children. Acta Anaesthesiol Scand 37: 725–729

    Article  PubMed  CAS  Google Scholar 

  • Hoffmann P, Gothe G (1988) Intravenöse Kombinations-Anästhesie mit Alfentanil bei Säuglingen. Anästhesist 37: 684–689

    CAS  Google Scholar 

  • Hug CC, Chaffman M (1984) Alfentanil: Pharmacology and uses in anaesthesia. Adis, Auckland

    Google Scholar 

  • Jaffe TB, Ramsey FM (1983) Attenuation of fentanyl-induced truncal rigidity. Anesthesiology 58: 562–584

    Article  PubMed  CAS  Google Scholar 

  • Janik R, Dick W (1988) Der Einfluß von Atropin, Fentanyl and Alfentanil auf kardiozirkulatorische Parameter and Thoraxrigidität in der Einleitungsphase einer Intubationsnarkose. Anästh Intensivther Notfallmed 23: 260–264

    Article  PubMed  CAS  Google Scholar 

  • Jorgensen NH, Coyle JP (1990) Intravenous droperidol decreases nausea and vomiting after alfentanil anesthesia without increasing recovery time. J Clin Anesth 2: 312–316

    Article  PubMed  CAS  Google Scholar 

  • Kapila A, Lang E, Glass P, Sebel P et al. (1994) MAC Reduction of lsoflurane by Remifentanil. Anesthesiology 81: A378

    Article  Google Scholar 

  • Kharasch ED, Mautz D, Bowdle TA (1994) Variability in alfentanil-pharmacokinetics: The essential role of cytochrome P 4503 A. Anesthesiology 81: A381

    Article  Google Scholar 

  • Knoche E, Dick W (1985) Kurznarkosen in der Gynäkologie. In: Zindler M, Hartung E (Hrsg) Alfentanil - ein neues ultrakurzwirkendes Opioid. Urban & Schwarzenberg, München

    Google Scholar 

  • Kuschinsky K, Hornykiewicz O (1972) Morphine katalepsy in the rat: relation to striatal dopamine metabolism. Eur J Phamacol 19: 119

    Article  CAS  Google Scholar 

  • LeDez KM, Swartz J, Strong A, Burrows FA, Lerman J (1986) The effects of age on the serum concentration of a-l-acidglycoprotein in newborns, infants and children. Anesthesiology 65: A421

    Article  Google Scholar 

  • Lehmann KA (1985) Pharmacokinetische Arzneimittelinteraktionen von Alfentanil mit Inhalationsnarkotika und einigen Substanzen der Neuroleptanalgesie. In: Zindler M, Hartung E (Hrsg) Alfentanil - ein neues ultrakurz-wirkendes Opioid. Urban & Schwarzenberg, München

    Google Scholar 

  • Levron JC, Fleisler B, Stephan P (1984) Pharmacokinetics of alfentanil in children aged 5 to 8 years. Unpublished data, on file. Janssen Pharmaceutica 1983 (zit. nach Hug u. Chaffman 1984)

    Google Scholar 

  • Marlow N, Windling AM, Peer A van, Heykants J (1990) Alfentanil pharmacokinetics in preterm infants. Arch Dis Child 65: 349–351

    Article  PubMed  CAS  Google Scholar 

  • Meuldermans W, Hurkmans RMA, Heykants JJP (1982) Plasma protein binding and distribution of fentanyl, sufentanil, alfentanil and lofentanil in blood. Archives Internationales de Parmacodynamie et de Therapie 25: 419

    Google Scholar 

  • Morton J, Hardman HD, Kamiyama Y, Donn KH, Glass PSA (1991) Analgesic efficacy of single escalating doses of Gl 87084B administered intravenously to healthy adult male volunteers. Anesthesiology 75: A378

    Article  Google Scholar 

  • Moyer JR (1987) Alfenta (alfentanil-HCL) injection: pharmacological and clinical profile. Anesthesiology 66: 17–23

    Article  Google Scholar 

  • Mulroy JJ, Davis PJ, Rymer DB et al. (1991) Safety and efficacy of alfentanil and halothane in pediatric surgical patients. Can J Anaesth 38: 445–449

    Article  PubMed  Google Scholar 

  • Nauta J, Lange S de, Koopman D, Spierdijk J, Kleef J van, Stanley TH (1982) Anesthetic induction with Alfentanil, a short acting narcotic analgesic. Anesth Analg 61: 267–272

    Article  PubMed  CAS  Google Scholar 

  • Ngai SH (1961) The effects of morphine and mepeddine on the central respiratory mechanisms in the cat: the action of levallorphane in antagonizing these effects. J Pharmacol Exp Ther 131: 91–102

    PubMed  CAS  Google Scholar 

  • Reinhold P, Vigfusson G (1990) Zur Alfentanil-Kombinationsanästhesie im Säuglingsalter. Anästh Intensivther Notfallmed 25: 135–139

    Article  PubMed  CAS  Google Scholar 

  • Roth B, Houben F, Hartwig S, Theisohn M, Schlünderc (1991) Erfahrungen zur Analgesie und Sedierung in der pädiatrischen Intensivmedizin. In: Hentschel WF (Hrsg) 1. Europäisches Analgesieforum–Die Analgesie im Mittelpunkt der Anästhesie. Urban & Schwarzenberg, München, S 247–253

    Google Scholar 

  • Roure P, Jean N, Leclerc AC et al. (1987) Pharmacokinetics of alfentanil in children undergoing surgery. Br J Anaesth 59: 1437–1440

    Article  PubMed  CAS  Google Scholar 

  • Rucquoi M, Camu F (1983) Cardiovascular responses of large doses of alfentanil and fentanyl. Br J Anaesth 55: 223–230

    CAS  Google Scholar 

  • Scamman FL (1983) Fentanyl 02-N2O rigidity and pulmonary compliance. Anesth Analg 62: 332

    Article  PubMed  CAS  Google Scholar 

  • Schenk HD (1993) Alfentanil - Portrait eines Opioids zur Anästhesie. Urban & Schwarzenberg, München

    Google Scholar 

  • Schüttler J, Stoeckel H (1993) Neue Opioide für die Anästhesie–Brauchen wir sie? Anästhesiol Intensivmed Notfallmed Schmerzther 28: 197–198

    Article  PubMed  Google Scholar 

  • Scuderi P, Wetchler B, Sung YF (1993) Treatment of postoperative nausea and vomiting after outpatient surgery with the 5-HT3 antagonist ondansetron. Anesthesiology 78: 15–20

    Article  PubMed  CAS  Google Scholar 

  • Spear RM, Rodarte A, Waldman JY, Flynn MA (1994) Propofol/Alfentanil for rapid intravenous Induction and tracheal Intubation without muscle relaxant in children. Anesthesiology 81: A1327

    Article  Google Scholar 

  • Steyn MP, Quinn AM, Gillespie JA et al. (1994) Tracheal intubation without neuromuscular block in children. Br J Anaesth 72: 403–406

    Article  PubMed  CAS  Google Scholar 

  • Van Peer A, Levron JC, Noorduin H, Heykants J (1984) Overview of the clini-cal pharmakokinetics of alfentanil. Acta Anaesthesiol Belg 35: 261–263

    PubMed  Google Scholar 

  • Westmoreland C, Hoke JF, Sebel PS, Hug CC, Muir KT (1993) Pharmacokinetics of Remifentanil (G1 87084B) and its metabolite. Anesthesiology 79: A372

    Article  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Reinhold, P., Schneider, P. (1998). Alfentanil und Remifentanil in der Kinderanästhesie. In: Funk, W., Hollnberger, H. (eds) Neue Pharmaka und Techniken in der Kinderanästhesie. Kinderanästhesie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58791-7_19

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58791-7_19

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-63532-1

  • Online ISBN: 978-3-642-58791-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics