Skip to main content

Transcatheter Arterial Chemotherapy and Chemoembolization of Liver Metastases

  • Chapter
Liver Malignancies

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

  • 277 Accesses

Abstract

Since the early 1960s, the use of percutaneous Seldinger’s technique has enabled any visceral arterial tree to be easily reached with low invasivity for diagnostic purposes. Therapy then became the extension of angiography, and arterial infusion chemotherapy (AIC) for liver cancer was first used by Sullivan (1963). Arterial embolization of liver tumors was also performed to reduce pain in large expansive masses or for emergency hemostasis in acute blood loss, and was applied to palliative treatment of the hepatocellular carcinoma by Doyon (1974) and by Goldstein et al.(1987).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Ajlouni MI, Merrick HW, Skeet RT, Dobelbower RR Jr (1990) Concomitant radiation therapy and constant infusion FUdR for unresectable hepatic metastases. Am J Clin Oncol Cancer Clin Trials 13:532–535

    CAS  Google Scholar 

  • Allen-Mersh TG, Earlam S, Fordy C, Abrams K, Houghton J (1994) Quality of life and survival with continuous hepatic-artery floxuridine infusion for colorectal lives metastases. Lancet 344:1255–1260

    PubMed  CAS  Google Scholar 

  • Aoki T, Kimura K, Koyanaga Y, et al (1991) Hepatic infusion-chemotherapy for liver metastases from stomach cancer-comparative study for intraarterial group and nonintraaterial group. Jpn J Cancer Chemother 18:2133–2136

    CAS  Google Scholar 

  • Aoki F, Mori T, Takahashi K, Moriyama Y, Tanaka S, Takatashi T (1993) Two cases of intrahepatic biloma during hepatic arterial infusion chemotherapy proved by CT-scan. Jpn J Cancer Chemother 20:1713–1716

    CAS  Google Scholar 

  • Arai Y (1994) Current arterial infusion chemotherapy for liver metastases and required studies. Jpn J Cancer Chemother 20: 1179–1183

    Google Scholar 

  • Arai Y, Sone Y, Inaba Y, et a1 (1993) Intermittent hepatic arterial infusion of high-dose 5-FU for liver metastases from colorectal cancer. Jpn J Cancer Chemother 20:1527–1530

    CAS  Google Scholar 

  • Arai Y, Inaba Y, Takeuchi Y, Ariyoshi Y (1997) Intermittent hepatic arterial infusion of high-dose 5FU on a weekly schedule for liver metastases from colorectal cancer. Can-cer Chemother Pharmacol 40:526–530

    CAS  Google Scholar 

  • Araki T, Hihara T, Kachi K, et al (1989) Newly developed transarterial chemoembolization material: CDDPlipiodol suspension. Gastrointest Radiol 14:46–48

    PubMed  CAS  Google Scholar 

  • Bilbao-Jaureguizar JI, Fernandez-Virgos A, Rodriquez-Cabello J, San-Julian-Artola MP, Fonseca-Cruz R, Longo-Areso JM (1991) Infusion de quimioterapia intraarterial por colaterales extrahepaticas en obstruccion de tronco celiaco. A proposito de un caso. Radiologia 33:489–491

    Google Scholar 

  • Chuang VP, Wallace S (1981) Hepatic artery embolization in the treatment of hepatic neoplasms. Radiology 140:51–58

    PubMed  CAS  Google Scholar 

  • Civalleri D, Scopinaro G, Balletto N, et al (1989) Changes in vascularity of liver tumours after hepatic arterial embolization with degradable starch microspheres.Br J Surg 76:699–703

    PubMed  CAS  Google Scholar 

  • Clark RA, Gallant TB (1987) Bile duct strictures associated with hepatic arterial infusion chemotherapy. Gastrointest Radiol 12:148–151

    PubMed  CAS  Google Scholar 

  • Coldwell DM, Mortimer JE (1991) Hepatic Artery embolization in the treatment of hepatic malignancies. Reg Cancer Treat 3:298–301

    Google Scholar 

  • Curley SA, Roh MS, Chase JL, Hohn DC, Johnson FE, Organ CH Jr (1993) Adjuvant hepatic arterial infusion chemotherapy after curative resection of colorectal liver metastases. Am J Surg 166:743–748

    PubMed  CAS  Google Scholar 

  • Davitti B, Fiorentini G, Guglielminetti D, et al (1992) Complications of port-catheter systems for intra-arterial hepatic chemotherapy: report of 78 patients. Reg Cancer Treat 5:163–166

    Google Scholar 

  • Dazzi C, Fiorentini G, Davitti B, et al (1994) High-dose intra-arterial plus intraperitoneal chemotherapy combined with hemofiltration in liver metastases from colorectal cancer.Tumori 80:204–208

    PubMed  CAS  Google Scholar 

  • De Dycker RP, Timmermann J (1991) Combined intraarterial hepatic infusion of degradable starch microspheres and cytostatics in the treatment of breast cancer liver metastases. Reg Cancer Treat 3:302–304

    Google Scholar 

  • Doyon D (1974) L’embolization arterielle hepatique dans les tumeurs malignes du foie. bourn Radiol Electrol 17:593–603

    CAS  Google Scholar 

  • Duprat G, Charnsangavej C, Wallace S, Carrasco CH (1988) Inferior phrenic artery embolization in the treatment of hepatic neoplasms. Acta Radiol 29:427–429

    PubMed  CAS  Google Scholar 

  • Dworkin MJ, Burke D, Earlam S, Fordy C, Allen Mersh TG (1995) Measurement of response to treatment in colorectal liver metastases. Br J Cancer British Journal of Cancer 71:873–876

    CAS  Google Scholar 

  • Fujimoto S (1994) Clinical evaluation of albumin micro-spheres containing anticancer drugs in primary hepatoma and metastatic liver cancer. Jpn J Cancer Chemother 20:998–1003

    Google Scholar 

  • Fujimoto S, Koike S, Takahashi M, et al (1993) Intra-arterial infusion chemotherapy with degradable starch microspheres and mitomycin C for unresectable hepatic metastasis from gastrointestinal cancer. Reg Cancer Treat 6:7–11

    Google Scholar 

  • Goldberg JA, Fenner J, Bessent RG, et al (1989) Clinical evaluation of angiotensin II enhanced perfusion scintigraphy in metastatic liver disease. Nucl Med Commun 10:557–566

    PubMed  CAS  Google Scholar 

  • Goldberg JA, Thomson JAK, McCurrach G, et al (1991a) Arteriovenous shunting in patients with colorectal liver metastases. Br J Cancer 63:466–468

    CAS  Google Scholar 

  • Goldberg JA, Willmott NS, Anderson JH, et al (1991b) The biodegradation of albumin microspheres used for regional chemotherapy in patients with colorectal liver metastases. Nucl Med Commun 12:57–63

    CAS  Google Scholar 

  • Goldberg JA, Murray T, Kerr DJ, et al (1991c) The use of angiotensin II as a potential method of targeting cytotoxic microspheres in patients with intrahepatic tumour. Br I Cancer 63:308–310

    CAS  Google Scholar 

  • Goldstein HM, Wallace S, Anderson JH, Bree RL, Gianturco C (1976) Transcatheter occlusion of abdominal tumors. Radiology 120:539–545

    PubMed  CAS  Google Scholar 

  • Gorich J, Hasan I, Sittek H, et al (1993) Embolization of primary and secondary liver tumors. Radiol Diagn 34:289–303

    Google Scholar 

  • Gorich J, Rilinger N, Sokiranski R, et al (1996) Embolization of liver neoplasms in patients with occluded celiac trunk. Reg Cancer Treat 9:79–82

    Google Scholar 

  • Grosso M, Zanon C, Zanon M (1997) Posizionamento percutaneo di cateteri intrarteriosi con reservoir per infusione sottocutanea. Radiol Med 94:226–232

    PubMed  CAS  Google Scholar 

  • Hafstrom L, Holmberg SB, Lindner P, et al (1994) Isolated regional liver perfusion with tumour necrosis factor-alpha followed by hyperthermic melphalan perfusion. Reg Cancer Treat 7:172–176

    Google Scholar 

  • Hanssen LE, Schrumpf E, Jacobsen MB, et al (1991) Extended experience with recombinant alpha -2b interferon with or without hepatic artery embolization in the treatment of midgut carcinoid tumours. A preliminary report. Acta Oncol 30:523–527

    CAS  Google Scholar 

  • Hemingway DM, Angerson WJ, Anderson JH, Goldberg JA, McArdle CS, Cooke TG (1992) Monitoring blood flow to colorectal liver metastases using laser Doppler flowmetry: the effect of angiotensin II. Br J Cancer 66:958–960

    PubMed  CAS  Google Scholar 

  • Hoefer RA Jr, Falk RL, Howell RS, Seeger J (1990) Computed tomographic arteriography of the liver following chronic intra-arterial FdUrd: a case illustrating multiple perfusion abnormalities. Reg Cancer Treat 3:19–22

    Google Scholar 

  • Hokita S, Takao S, Tokushige M, Maenohara S, Aikou T, Shimazu H (1989) Two-route chemotherapy under AT-II induced hypertension using totally implanted injection port system for liver metastases derived from digestive cancers. Jpn J Cancer Chemother 16:2901–2904

    CAS  Google Scholar 

  • Hoogewoud H-M (1994) La chimio-embolisation hepatique. Med Hyg 52:1544–1548

    Google Scholar 

  • Ichikawa W, Nihei Z, Sawai S, et al (1992) Efficacy of intra-arterial infusion chemotherapy for metastatic liver tumors of the colon cancer. Reg Cancer Treat 5:154–158

    Google Scholar 

  • Inoue H, Kobayashi H, Itoh Y, Shinohara-S (1989) Treatment of liver metastases by arterial injection of adriamycin/ mitomycin C lipiodol suspension. Acta Radiol 30: 603–608

    PubMed  CAS  Google Scholar 

  • Inoue Y, Nakamura H, Takashima S, Yamazaki K, Toyoshima H, Iwasaki M (1991) Biloma following transcatheter oily chemoembolization. Radiat Med 9:57–60

    PubMed  CAS  Google Scholar 

  • Inoue Y, Machida K, Honda N, et al (1997) Effect of Angiotensin II on arteriovenous shunting assessed by hepatic arterial perfusion scintigraphy. Am J Clin Oncol Cancer Clin Trials 20:237–241

    CAS  Google Scholar 

  • Itano S, Hirai K, Yoshida T, et al (1993) Complication of gastro duodenum with intra-hepatic arterial infusion chemotherapy using implantable reservoir system for hepatic tumors. Jpn J Cancer Chemother 20:1512–1515

    CAS  Google Scholar 

  • Iwasaki Y, Kitamura M, Arai K (1996) Induced hypertensive chemotherapy with angiotensin II for liver metastases from gastric cancer. Jpn J Cancer Chemother 23:1558–1560

    CAS  Google Scholar 

  • Chung JW, Park J, Im JG, Han JK, Han MC (1993) Pulmonary oil embolism after transcatheter oily chemoembolization of hepatocellular carcinoma. Radiology 187:689–693

    PubMed  CAS  Google Scholar 

  • Chung JW, Park J, Han JK, et al (1996) Hepatic tumors: predisposing factors for complications of transcatheter oily chemoembolization. Radiology 198:33–40

    PubMed  CAS  Google Scholar 

  • Kameoka S, Seshimo A, Hamann К (1995) Hepatic atrophy due to intra-arterial chemotherapy for liver metastasis. J Tokyo Women’s Med Coll 65:855–859

    Google Scholar 

  • Kameyama M, Fukuda I, Imaoka S, et a1 (1988) Transcatheter arterial chemoembolization for liver metastases of colorectal cancer (Lipiodol cisplatin sandwich therapy). Jpn J Cancer Chemother 15:2510–2513

    CAS  Google Scholar 

  • kameyama M, Fukuda I, Imaoka S, et a1 (1989) Stagnation of liver blood and effectiveness of intraarterial chemotherapy for metastatic colorectal cancer. Jpn J Cancer Chemother 16:2894–2896

    CAS  Google Scholar 

  • kameyama M, Imaoka S, Fukuda I, et al (1993) Delayed washout of intratumor blood flow is associated with good response to intraarterial chemoembolization for liver metastasis of colorectal cancer. Surgery 114:97–101

    PubMed  CAS  Google Scholar 

  • Kemeny N, Lokich JJ, Anderson N, Ahlgren JD (1993) Recent advances in the treatment of advanced colorectal cancer. Cancer 71:9–18

    PubMed  CAS  Google Scholar 

  • kimoto T, Nagasue N, Kohno H, et al (1995) Repeated hepatic dearterialization for unresectable liver metastases from gastric cancer: review of five cases. HPB Surg 8:175–180

    PubMed  CAS  Google Scholar 

  • Kitada M, Shibata T, Takami M, et al (1993) Liver metastases from breast cancer: survival and an attempt at cauterization and thermocoagulation therapy combined with selective intra-arterial infusion chemotherapy. Jpn J Cancer Chemother 20:1601–1604

    CAS  Google Scholar 

  • Kobayashi H, Inoue H, Shimada J, et al (1987) Intra-arterial injection of adriamycin/mitomycin C lipiodol suspension in liver metastases. Acta Radiol 28:275–280

    PubMed  CAS  Google Scholar 

  • Kohno S, Oda Y, Toya N, et a1 (1995) Evaluation of 5-FU, leucovorin, etoposide, and cisplatin (FLEP) chemotherapy by hepatic artery injection in the treatment of multiple liver metastases from gastric cancer. Jpn J Cancer Chemother 22:695–698

    CAS  Google Scholar 

  • Koike S, Fujimoto S, Guhji M, et al (1988) Repeated intra-arterial chemotherapy combined with mitomycin c and degradable starch microspheres for inoperable metastatic hepatic cancer. JpnJ Cancer Chemother 15:2601–2605

    CAS  Google Scholar 

  • Koike S, Fujimoto S, Guhji M, et al (1989) Effect of degradable starch microspheres (DSM) on hepatic hemodynamics. Jpn J Cancer Chemother 16:2818–2821

    CAS  Google Scholar 

  • Kondo M (1994) Chemo-embolization with DSM against hepatic malignancies. Jpn J Cancer Chemother 20:1186–1190

    Google Scholar 

  • Konno T (1994) Basic and clinical use of arterial injection therapy with oily anticancer agents. Jpn J Cancer Chemother 20: 1190–1194

    Google Scholar 

  • Koyanagi Y (1994) Low-dose intermittent arterial infusion therapy. Jpn J Cancer Chemother 20: 1198–1202

    Google Scholar 

  • Kuroda C, Sakurai M, Monden M, et al (1989) Transcatheter arterial embolization for metastatic liver tumors: a study in resected cases. Cardiovasc Intervent Radiol 12:72–75

    PubMed  CAS  Google Scholar 

  • Lang Ek, Brown CL Jr (1993) Colorectal metastases to the liver: selective chemoembolization. Radiology 189:417–422

    Google Scholar 

  • Leen E, Angerson WJ, Warren H, et al (1993) Hepatic arterial haemodynamics changes following intra-arterial angiotensin II infusion: duplex/color Doppler sonography. Clin Radiol 47:321–324

    PubMed  CAS  Google Scholar 

  • Links M, Ross W, Clingan P, et al (1993) Treatment of liver metastases with intra arterial Lipiodol - Adriamjycin. Reg Cancer Treat 6:121–124

    Google Scholar 

  • Lorenz M, Herrmann G, Kirkowa Reimann M, et al (1919) Temporary chemoembolization of colorectal liver me-tastases with degradable starch microspheres. Eur J Surg Oncol 15:453–462

    Google Scholar 

  • Lygidakis NJ, Thodorakopoulou M, Dedemadi G, et al (1997) Resection of unresectable secondary liver tumors - New frontiers in liver surgery. Hepatogastroenterology 44:1632–1640

    PubMed  CAS  Google Scholar 

  • Maeda К (1994) Transcatheter arterial embolization in liver metastases from colorectal cancer. Jpn J Cancer Chemother 20: 1045–1055

    Google Scholar 

  • Mayor AID, Parkin A, Riley A, et al (1987) Initial clinical experience with degradable starch microspheres. Nucl Med Commun 8:1011–1018

    Google Scholar 

  • Miller DL, Carrasquillo JA, Lutz RJ, Chang AE Hepatic perfusion during hepatic artery infusion chemotherapy: evaluation with perfusion CT and perfusion scintigraphy. J Comput Assist Tomogr 13:958–964

    Google Scholar 

  • Morandi C, Colopi S, Arai Y, et al (1998) Posizionamento percutaneo di catetere di Port nell’arteria epatica per la chemioterapia delle metastasi secondo la tecnica di Arai. Radiol Med 95:357–361

    PubMed  CAS  Google Scholar 

  • Mori M, Hidaka K, Mashima H, Katano M, Kishikawa T, Hisatsugu T (1993) Clinical study on the effect of continuous transarterial infusion chemotherapy of CDDP for metastatic liver tumors. Jpn J Cancer Chemother 20:15471550

    Google Scholar 

  • Nagata Y, Hiraoka M, Nishimura Y, et al (1997) Clinical results of radiofrequency hyperthermia for malignant liver tumors. Int J Radiat Oncol Biol Phys 38:359–365

    PubMed  CAS  Google Scholar 

  • Nakagawa H, Kobayashi K, Tono T, et al (1996) Combir ation with intra-hepatic arterial infusion of low dose cisplatin and oral administration of high dose doxyfluridir е for patients with liver metastases of gastric cancer. Jpn J Cancer Chemother 23:783–785

    CAS  Google Scholar 

  • Nakamura К (1992) Hepatic blood flow in patients treated by continuous hepatic artery infusion chemotherapy. Jpn J Nucl Med 29:377–383

    CAS  Google Scholar 

  • Nakamura H (1994) Liver chemoembolization. Jpn J Cancer Chemother 20:1159–1165

    Google Scholar 

  • Nakamura H, Hashimoto T, Oi H, Sawada S, Furui S (1991) Prevention of gastric complications in hepatic arterial chemoembolization. Balloon catheter occlusion technique. Acta Radiol 32:81–82

    PubMed  CAS  Google Scholar 

  • Nakayama T, Tamaki Y, Tohno K, et al (1993) Continuous intra-hepatic-arterial infusion of low dose 5-fluorouraci1 for colorectal cancer patients with unresectable liver metastases. Jpn J Cancer Chemother 20:1504–1506

    CAS  Google Scholar 

  • Nobin A, Mansson B, Lunderquist A (1989) Evaluation of temporary liver dearterialization and embolization in patients with metastatic carcinoid tumor. Acta Oncol 28:419–424

    PubMed  CAS  Google Scholar 

  • Noda M, Kusunoki M, Yanagi H, Yamamura T. Utsunomiya I (1996) Hepatic artery-biliary fistula during infusion chemotherapy. Hepatogastroenterology 43:1387–1389

    PubMed  CAS  Google Scholar 

  • Ohori M, Umekita N, Maeshiro T, Miyamoto S, Yamada F, Awane Y (1996) Common bile duct fistula caused by hepatic arterial infusion chemotherapy. Jpn J Cancer Chemother 23:1565–1567

    CAS  Google Scholar 

  • Pentecost MJ (1993) Transcatheter treatment of hepatic metastases. AIR 160:1171–1175

    CAS  Google Scholar 

  • Perring S, Hind R, Fleming J, Birch S, Batty V, Taylor I (1994) Dosimetric assessment of radiolabelled lipiodol as a potential therapeutic agent in colorectal liver metastases using combined CT and SPECT. Nucl Med Commun 15:34–38

    PubMed  CAS  Google Scholar 

  • Piperkova E, Kurteva G, Grueva A, Braikow N, Kurtev P (1994) Role of (99 m)Tc-albumin microspheres for assessment of vascularisation of liver metastases in patients with colorectal carcinoma. Radiol Diagn 35:323–327

    Google Scholar 

  • Ravikumar TS, Dixon-K (1996) Isolated liver perfusion for liver metastases: pharmacokinetic advantage? Surg Oncol Clin North Am 5:443–449

    CAS  Google Scholar 

  • Richardet J P, Lons T, Sibony M, et al (1994) Sclerosing cholangitis after oily hepatic arterial chemoembolisation. Gastroenterol Clin Biol 18:168–171

    PubMed  CAS  Google Scholar 

  • Ross WB, Morris DL, Clingan PR (1996) Major upper gastrointestinal haemorrhage associated with hepatic arterial chemoperfusion. Aust New Zealand J Surg 66:816–819

    CAS  Google Scholar 

  • Roth J, Wallner B, Safi F (1989) Arterial perfusion abnormalities of the liver after hepatic arterial infusion chemotherapy and their correlation with changes in the metastases: evaluation with CT and angiography. AJR 153:751–754

    PubMed  CAS  Google Scholar 

  • Roversi R (1996) Perfusione antiblastica del fegato in ipossia. Interventional Radiology in Oncology, Milan, Italy, pp 35–49

    Google Scholar 

  • Roversi R, Cavallo G, Ricci S, Rossi G, Roversi M, Fiorentini GM (1997) Perfusione antiblastica ipossica con blocco di flusso nella terapia delle metastasi epatiche: risultati preliminari. Radiol Med 93:410–417

    PubMed  CAS  Google Scholar 

  • Sakamoto Y, Fujita M, Ota J, Sugiycrma R, Sugimoto T, Taguchi T (1993) Enhancing effects of degradable starch microspheres on experimental intra-arterial chemotherapy with adriamycin in nude rat models with human gastric cancer xenografts. Reg Cancer Treat 6:12–18

    Google Scholar 

  • Saltz L (1991) Drug treatment of colorectal cancer: current status. Drugs 42:616–627

    PubMed  CAS  Google Scholar 

  • Sanz Altamira PM, Spence LD, Huberman MS, et al (1997) Selective chemoembolization in the management of hepatic metastases in refractory colorectal carcinoma: a phase II trial. Dis Colon Rectum 40:770–775

    PubMed  CAS  Google Scholar 

  • Sasaki Y (1994) Sandwich therapy with Lipiodol and cisplatin in hepatocellular carcinoma Jpn J Cancer Chemother 20: 1022–1030

    Google Scholar 

  • Sato T (1994) Intrarterial cancer chemotherapy. Jpn J Cancer Chemother 20: 1145–1150

    Google Scholar 

  • Sato S, Nabeyama A, Nakashima A, et al (1992) A case of recurrent liver tumor from gastric cancer responding remarkably to hepatic arterial infusion of doses large mitomycin C and 5-fluorouracil. Jpn J Cancer Chemother 19:537–539

    CAS  Google Scholar 

  • Satoh O, Sakaguchi H, Yoshioka T, et al (1990) Transarterial hepatic embolization for metastatic liver cancers; with reference to 17 cases of survivals for more than 2 years. Jpn J Clin Radiol 35:345–352

    CAS  Google Scholar 

  • Sawada S, Fujiwara Y, Koyama T, et al (1992) Percutaneous transfemoral arterial infusion chemotherapy for metastatic liver tumors - Placement of 3 Fr balloon catheters. Radiat Med 10:6–12

    PubMed  CAS  Google Scholar 

  • Schneebnum S, Walker MJ, Young D, Farrar WB, Minton JP, Gardner B (1994) The regional treatment of liver metastases from breast cancer. J Surg Oncol 55:26–32

    Google Scholar 

  • Seki H, Kimura M, Kamura T, Miura T, Yoshimura N, Sakai K (1996) Hepatic perfusion abnormalities during treatment with hepatic arterial infusion chemotherapy: value of CT arteriography using an implantable port system. J Comput Assist Tomogr 20:343–348

    PubMed  CAS  Google Scholar 

  • Shida H, Ban K, Matsumoto M, et al (1995) Continuous intraarterial infusion of 5-fluorouracil plus leucovorin for liver metastases from colorectal cancer. Jpn I Cancer Chemother 22:221–225

    CAS  Google Scholar 

  • Shuto K, Okazumi S, Takayama W, et al (1997) Evaluation of СТА for arterial infusion chemotherapy for liver metastasis from colorectal cancer. Jpn J Cancer Chemother 24:1749–1752

    CAS  Google Scholar 

  • Sidibe S, Rougier P, Lumbroso J, et al (1989) Controles de perfusion par angioscintigraphie lors des chimiotherapies intra-arterielles hepatiques. Presse Med 18:2045–2049

    PubMed  CAS  Google Scholar 

  • Sigurdson ER, Ridge JA, Kemeny N, Daly JM (1987) Tumor and liver drug uptake following hepatic artery and portal vein infusion. J Clin Oncol 5:1836–1840

    PubMed  CAS  Google Scholar 

  • Sone Y, Arai Y, Mukaijo T, Nakatsuka A, Sasaki F, Kido C (1993) Changes of arterial blood flow patterns by patients’ posture during hepatic arterial infusion chemotherapy assessed by (99m) Тс-МАA perfusion scintigraphy. Kakuigaku 30:1353–1358

    CAS  Google Scholar 

  • Spulen MC (1997) Chemoembolization of hepatic malignancies. Semin Intervent Radiol 14:305–311

    Google Scholar 

  • Starkhammar H, Hakansson L (1987) Effect of starch microspheres on the passage of labelled erythrocytes and a low molecular weight marker through the liver. Acta Oncol 26:361–365

    PubMed  CAS  Google Scholar 

  • Starkhammar H, Hakansson L, Morales O, Svedberg J (1987) Intra-arterial mitomycin c treatment of unresectab e liver tumours. Preliminary results on the effect of degradable starch microspheres. Acta Oncol 26:295–300

    PubMed  CAS  Google Scholar 

  • Stephens FO (1992) Proposal for management of colorectal metastases with hepatic artery 5-FU infusion followed by portal vein FUDR. Reg Cancer Treat 5:146–153

    Google Scholar 

  • Sugarbaker PH, Steves MA (1993) A cytoreductive approach to treatment of multiple liver metastases. J Surg Oncol 53:161–165

    Google Scholar 

  • Sugimoto E (1994) Value of transcatheter arterial embolization using lipiodol for hepatic metastases. J Saitama Med Sch 21:185–191

    Google Scholar 

  • Sugimoto I, Ku Y, Tominaga M, et al (1997) A case of multiple colonic liver metastases treated successfully with percutaneous isolated liver chemoperfusion using cisplatin. Jpn J Cancer Chemother 24:1753–1756

    CAS  Google Scholar 

  • Sullivan RD (1963) Continuous AIC of human liver cancer using 5-fluoro-2-deoxyuridine. Proc Am Assoc Cencer Res 4:66–78

    Google Scholar 

  • Suzuki Y, Sano A, Hatabu H, et al (1992) Transcatheter arterial infusion of adriamycin-lipiodol suspension to the patients with metastatic liver tumor. Jpn J Cancer Chemother 19:323–326

    CAS  Google Scholar 

  • Suzuki S, Arai K, Arai H, et al (1997) Prognosis of hepatic metastasis from colorectal cancer following hepatic resection and arterial infusion chemotherapy - Assessment from the percentage of tumor involved area. Jpn J Cancer Chemother 24:1699–1702

    CAS  Google Scholar 

  • Taguchi T (1994) Arterial Infusion Chemotherapy. Jpn J Cancer Chemother 20:1031–1039

    Google Scholar 

  • Takayasu K, Shima Y, Muramatsu Y, et al (1987) Hepatocellular carcinoma: treatment with intraarterial iodized oil with and without chemotherapeutic agents. Radiology 163:345–351

    PubMed  CAS  Google Scholar 

  • Tanada M, Saeki T, Takashima S, Mogami H, Hyoudou I, Jinno К (1996) Intrahepatic arterial infusion chemotherapy for the colon cancer patients with liver metastases - A comparison of arterial embolization chemotherapy versus continuous arterial infusion chemotherapy. Jpn J Cancer Chemother 23:1440–1442

    CAS  Google Scholar 

  • Tanada M, Yokoyama N, Kurita A, et al (1997) Histological effect of arterial embolization chemotherapy for metastatic liver tumors from colorectal cancer - Report of cases of hepatectomy after arterial embolization chemotherapy. Jpn J Cancer Chemother 24:1745–1748

    CAS  Google Scholar 

  • Tanaka Y, Yamamoto K, Murata T, Nagata К (1992) Effects of multimodal treatment and hyperthermia on hepatic tumors. Cancer Chemother Pharmacol 31:111–114

    Google Scholar 

  • Taniguchi H, Koyama H, Masuyama M, et a1 (1996) Angiotensin-II-induced hypertension chemotherapy: Evaluation of hepatic blood flow with oxygen-15 PET. J Nucl Med 37:1522–1523

    PubMed  CAS  Google Scholar 

  • Teder H, Johansson C J (1993) The effect of different dosages of degradable starch microspheres (Sphеrеx registered) on the distribution of doxorubicin regionally administered to the rat. Anticancer Res 13:2161–2164

    PubMed  CAS  Google Scholar 

  • Theicher BA, Lazo JS, Sartorelli AC (1981) Classification of antineoplastic agents by their selective toxicities toward oxygenated and hypoxic tumor cells. Cancer 41:73–78

    Google Scholar 

  • Therasse E, Breittmayer F, Roche A, et al (1993) Transcatheter chemoembolization of progressive carcinoid liver metastasis. Radiology 189:541–547

    PubMed  CAS  Google Scholar 

  • Tomita M (1994) Arterial infusion chemotherapy and transcatheter arterial embolization (TAE) therapy for primary and metastatic malignant liver tumors. Jpn J Cancer Chemother 20:1011–1018

    Google Scholar 

  • Tsuji Y, Katsuki Y, Yasuda T, Nishimura A, Shinohara M (1993) Intra-arterial chemotherapy with 5-FU (weekly high dose 5-FU HAI) for the prevention of tumor recurrence in residual liver after hepatic resection of metastasis from colorectal cancer. Jpn J Cancer Chemother 20:1520–1523

    CAS  Google Scholar 

  • Tsujitani S, Watanabe A, Kakeji Y, et al (1991) Hepatic recurrence not prevented with low-dosage long-term intraportal 5-FU infusion after resection of colorectal liver metastasis. Eur J Surg Oncol 15:526–529

    Google Scholar 

  • Tsuruta S, Mitsuoka S, Tajima H, et al (1990) Hepatic bile cyst, as a side effect of transcatheter oily chemoembolization: report of a case. Acta Hepatol Jap 31:576–580

    Google Scholar 

  • Une Y, Uchino J, Yasuhara M, et al (1993) Intra-arterial infusion chemotherapy on unresectable hepatocellular carcinoma under occlusion of hepatic arterial flow. Clip Tlier 15:347–354

    CAS  Google Scholar 

  • Vogl TJ, Mack MG, Straub R, Roggan A, Felix R (1997) Magnetic resonance imaging - Guided abdominal i:aterven tional radiology: laser-induced thermotherapy of liver metastases. Endoscopy 29:577–583

    PubMed  CAS  Google Scholar 

  • Wacker F, Fobbe F, Boese Landgraf J, Wagner A (1995) Pseudothrombosierung Der Arteria Hepatica Cornmunis Bei Der Regionalen Chemotherapie Von Lebermetastasen. ROFO 162:538–540

    PubMed  CAS  Google Scholar 

  • Wacker FK, Boese Landgraf J, Wagner A, Albrecht D, Wolf KJ, Fobbe F (1997) Minimally invasive catheter impkntation for regional chemotherapy of the liver: a new percutaneous transsubclavian approach. Cardiovasc Irtervent Radiol 20:128–132

    CAS  Google Scholar 

  • Wallace S, Carrasco CH, Charnsangavej C, Richli WR, Wright K, Gianturco C (1990) Hepatic artery infusion and chemoembolization in the management of liver metastases. Cardiovasc Intervent Radiol 13:153–160

    PubMed  CAS  Google Scholar 

  • Wiley AL Jr, Wirtanen GW, Stephenson JA, Ramsez G, Demets D, Lee JW (1989) Combined hepatic artery 5-fluerouracil and irradiation of liver metastases. A randomized study. Cancer 64:1783–1789

    PubMed  Google Scholar 

  • Yamamoto M, Miura K, Iiгuka H, Yamamoto Y, Fujii H (1993) Application of subcutaneously implanted infusion pump for continuous infusion of IL-2 and intermittent Doxorubicin injections to hepatic artery in advanced hepatocellular carcinoma. Reg Cancer Treat 6:125–130

    Google Scholar 

  • Yamamura T, Hanai A, Oikawa H, et al (1993) Arterial, infusion chemotherapy of 5-FU and leucovorin for patients with liver metastases from cololectal cancer. Jpn J Cancer Chemother 20:1516–1519

    CAS  Google Scholar 

  • Yamashita Y, Takahashi M, Bussaka H, Fukushina S, Kawaguchi T, Nakano M (1989) Intraarterial infusion of 5fluoro-2-deoxyuridine-C8 dissolved in a lymphographic agent in malignant liver tumors: a preliminary report. Cancer 64:2437–2444

    PubMed  CAS  Google Scholar 

  • Yamashita Y, Takahashi M, Koga Y, et al (1990) Prognostic factors in liver metastases after transcatheter arterial embolization or arterial infusion. Acta Radiol 31:269–274

    PubMed  CAS  Google Scholar 

  • Zeiss J, Merrick HW, Savolaine ER, Woldenberg LS, Kim К, Schlembach PJ (1990) Fatty liver change as a result of hepatic artery infusion chemotherapy. Am J Clin Oncol Cancer Clin Trials 13:156–160

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Roversi, R. (1999). Transcatheter Arterial Chemotherapy and Chemoembolization of Liver Metastases. In: Bartolozzi, C., Lencioni, R. (eds) Liver Malignancies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58641-5_25

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58641-5_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63679-0

  • Online ISBN: 978-3-642-58641-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics