Skip to main content
SpringerLink
Log in

Radiofrequency Thermal Ablation of Liver Metastases

  • Chapter
Liver Malignancies

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

Abstract

Percutaneous image-guided ablative therapies using thermal energy sources have received much recent attention as minimally invasive strategies to treat either benign or malignant diseases. Radiofrequency (RF) induced tissue coagulation has been used in early clinical trials for the treatment of intracranial lesions (Anzai et al. 1995; Cosman et al. 1983), osteoid osteomas (Rosenthal et al. 1995) and hepatocellular carcinomas (HCCs) (Rossi et al. 1993, 1996). Subsequently, the treatment of primary and secondary liver tumors has become the most interesting field of application of radiofrequency, mostly due to the advantages compared to surgical resection, e.g., reduced morbidity and mortality, low cost, and suitability for real-time image guidance. However, for some years the treatment of colorectal metastases using RF ablation alone has been promising, but less efficacious than that observed for HCCs: this has to be related to differences in histopathology and technical limitations.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 39.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 54.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Anzai Y, Lufkin R, DeSalles A, et al (1995) Preliminary experience with MR-guided thermal ablation of brain tumors. AJR 16:39–48

    CAS  Google Scholar 

  • Cady B, Stone MD (1991) The role of surgical resection of liver metastases in colorectal carcinoma. Sem Oncol 18:399–406

    CAS  Google Scholar 

  • Cosman ER, Nashold BS, Bedenbaugh P (1983) Stereotactic radiofrequency lesion making. Appl Neurophysiol 46:160–166

    PubMed  CAS  Google Scholar 

  • Cosman ER, Nashold BS, Ovelman-Levitt J (1984) Theoretical aspects of radiofrequency lesions in the dorsal root entry zone. Neurosurg 15:945–950

    Article  CAS  Google Scholar 

  • Cosman ER, Rittman WJ, Nashold BS, et al (1988) Radiofrequency lesions generation and its effect on tissue impedence. Appl Neurophysiol 51:230–242

    PubMed  CAS  Google Scholar 

  • Doci R, Gennari L, Bignami, et al (1991) One hundred patients with hepatic metastases from colorectal cancer treated by resection: analysis of prognostic determinants. Br J Surg 78:797–801

    Article  PubMed  CAS  Google Scholar 

  • Dodd GD III, Halff GA, Rhim H, et al (1997) Radiofrequency thermal ablation of hepatic tumors. Radiology 205(Р):723

    Google Scholar 

  • Gayowski TJ, Iwatsuki S, Madariaga JR, et al (1994) Experience in hepatic resection for metastatic colorectal cancer: analysis of clinical and pathologic risk factors. Surgery 116:703–711

    PubMed  CAS  Google Scholar 

  • Goldberg SN, Gazelle GS, Dawson SL, et al (1995a) Tissue ablation with radiofrequency: Effect of probe size, gauge, duration, and temperature on lesion volume. Acad Radiol 2:399–404

    Article  CAS  Google Scholar 

  • Goldberg SN, Gazelle GS, Dawson SL, et al (1995b) Radiofrequency tissue ablation using multiprobe arrays: greater tissue destruction than multiple probes operating alone. Acad Radiol 2:670–674

    Article  CAS  Google Scholar 

  • Goldberg SN, Gazelle GS, Solbiati L, et al (1996a) Radiofrequency tissue ablation: increased lesion diameter with a perfusion electrode. Acad Radiol 3:636–644

    Article  CAS  Google Scholar 

  • Goldberg SN, Hahn PF, Schima S, et al (1996b) Percutaneous radiofrequency tissue ablation in the liver: increased coagulation necrosis with portal venous occlusion. Radiology 201(Р):250

    Google Scholar 

  • Goldberg SN, Gazelle GS, Solbiati L, et al (1997a) Large volume radiofrequency tissue ablation: increased coagulation with pulsed technique. Radiology 205(P):258

    Google Scholar 

  • Goldberg SN, Livraghi T, Solbiati L, et al (1997b) In situ ablation of focal hepatic neoplasms. In: GS Gazeile, S Saini, and PR Mueller (eds) Hepatobiliary and pancreatic radiology: imaging and intervention. Thieme Medical Pub, New York, pp 470–502

    Google Scholar 

  • Goldberg SN, Solbiati L, Hahn PF, et al (1998) Large-volume tissue ablation with radiofrequency by using a clustered, internally cooled electrode technique: laboratory and clinical experience in liver metastases. Radiology 209:371–379

    PubMed  CAS  Google Scholar 

  • Griffith KD, Sugarbaker PH, Chang AE (1990) Repeat hepatic resections for colorectal metastases. Surgery 107:101–104

    PubMed  CAS  Google Scholar 

  • Harned RK, Chezmar JL, Nelson RC (1994) Recurrent tumor after resection of hepatic metastases from colorectal carcinoma: location and time of discovery as determined by CT. AJR 163:93–97

    PubMed  Google Scholar 

  • Hemming AW, Langer B (1994) Repeat resection of recurrent hepatic colorectal metastases. Br J Surg 81:1553–1554

    Article  PubMed  CAS  Google Scholar 

  • Hughes KS, Simon R, Songhorabodi S, et al (1988) Resection of the liver for colorectal carcinoma metastases: a multiinstitutional study of indications for resetting. Surgery 103:278–288

    Google Scholar 

  • Hunt RD (1966) Microscopic histochemical methods for the demostration of enzymes. In: Thompson SW (ed) Selected histochemical and histopathological riethods. Charles C. Thomas, Springfield, pp 615–748

    Google Scholar 

  • Lehnert T, Otto G, Herfarth C (1995) Therapeutic mudalit7.es and prognostic factors for primary and secondary liver tumor. World J Surg 19:252–263

    Article  PubMed  CAS  Google Scholar 

  • Le Veen RF (1997) Laser hyperthermia and radiofrequency ablation of hepatic lesions. Semin Int Rad 14:313–324

    Google Scholar 

  • Livraghi T, Goldberg SN, Monti F, et al (1997) Saline-enhanced radiofrequency tissue ablation in the treatment of liver metastases. Radiology 202:205–210

    PubMed  CAS  Google Scholar 

  • Lorentzen T (1996) A cooled needle electrode for radiofrequency tissue ablation: thermodynamic aspects of improved performance compared with cone itional needle design. Acad Radiol 3:556–563

    Article  PubMed  CAS  Google Scholar 

  • McGahan JP, Brock JN, Tessluk H, et al (1992a) Hepatic ablation with use of radiofrequency electrocautery in thе animal model. JVIR 3:291–297

    Article  CAS  Google Scholar 

  • McGahan JP, Wei-Zhong G, Brock JM, et al (1992b) Hepatic ablation using bipolar radiofrequency electrocautery, Acad Radiol 3:418–422

    Article  Google Scholar 

  • Petrelli NJ, Gupta B, Piedmonte M, et al (1991) Morbidiry and survival of liver resection for colorectal adenocarcinoma. Dis Colon Rectum 34:899–904

    Article  PubMed  CAS  Google Scholar 

  • Rosenthal DI, Springfield DS, Gebhart MC, et al (1995) Osteoid osteoma: percutaneous radiofrequency ablation. Radiology 197:451–454

    PubMed  CAS  Google Scholar 

  • Rossi S, Fornari F, Pathies C, et al (1990) Thermal lesions induced by 480 KHz localized current field in Guinea pig and pig liver. Tumori 76:54–57

    PubMed  CAS  Google Scholar 

  • Rossi S, Fornari F, Buscarini L (1993) Percutaneous ultrasound-guided radiofrequency electrocautery for the treatment of small hepatocellular carcinoma. J Intery Radiol 8:97–103

    Google Scholar 

  • Rossi S, Di Stasi M, Buscarini E, et al (1996) Percutaneous RF interstitial thermal ablation in the treatment of hepatic cancer. AIR 167:759–768

    CAS  Google Scholar 

  • Rossi S, Buscarini E, Garbagnati F, et al (1998) Percutaneous treatment of small hepatic tumors by an expandable RF needle electrode. AIR 170:1015–1022

    CAS  Google Scholar 

  • Saenz NC, Cady B, McDermott WV, et al (1989) Experience with colorectal carcinoma metastatic to the liver. Surg Clin North Am 69:361–70

    PubMed  CAS  Google Scholar 

  • Siperstein AE, Rogers SJ, Hansen PD, et al (1997) Laparoscopic thermal ablation of hepatic neuroendocrine tumor metastases. Surgery 122:1147–1155

    Article  PubMed  CAS  Google Scholar 

  • Sironi S, Vanzulli A, De Cobelli F, et al (1996) Percutaneous US-guided radiofrequency ablation of liver metastases: dynamic MR imaging follow-up. Radiology 201(Р):250

    Google Scholar 

  • Solbiati L, Ierace I, Crespi L, et al (1996) Three-dimensional power Doppler with an intravascular echo enhancement agent and second harmonic imaging in RF ablation of liver metastases. Radiology 201(P):196

    Google Scholar 

  • Solbiati L, Goldberg SN, Ierace T, et al (1997) Hepatic metastases: percutaneous radio-frequency ablation with cooled-tip electrodes. Radiology 205:367–374

    PubMed  CAS  Google Scholar 

  • Solbiati L, Goldberg SN, Ierace T, et al (1998) Long-term follow-up of liver metastases treated with percutaneous US-guided radiofrequency ablation using internally-cooled electrodes. Radiology 209(P):449

    Google Scholar 

  • Solbiati L, Goldberg SN, Ierace T, et al (1999) Radiofrequency ablation of hepatic metastases: post-procedural assessment with a US microbubble contrast agent - early experience. Radiology 211:643–649

    PubMed  CAS  Google Scholar 

  • Stangl R, Altendorf-Hofmann A, Charneley RM, et al (1994) Factors influencing the natural history of colorectal liver metastases. Lancet 343:1405–1410

    Article  PubMed  CAS  Google Scholar 

  • Steele G Jr, Ravikumar TS (1989) Resection of hepatic metastases from colorectal cancer: biologic perspectives. Ann Surg 210:127–138

    Article  PubMed  Google Scholar 

  • Sugihara K, Hojo K, Moriya Y, et al (1993) Pattern of recurrence after hepatic resection for colorectal metastases. J Surg 80:1032–1035

    CAS  Google Scholar 

  • Tellez C, Benson AB, Lyster MT, et al (1998) Phase II trial chemoembolization for the treatment of metastatic colorectal carcinoma to the liver and review of the literature. Cancer; 82:1250–1259

    Article  PubMed  CAS  Google Scholar 

  • Wolf RF, Goodnight JE, Krag DE, et al (1991) Results of resection and proposed guidelines for patient selection in instances of noncolorectal hepatic metastases. Surg Gynecol Obstet 173:454–459

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Radiology, General Hospital, Piazzale Solaro 3, Busto Arsizio, I-21052, Varese, Italy

    L. Solbiati MD, T. Ierace MD, M. Dellanoce MD & L. Cova MD

  2. Department of Radiology, Beth Israel Deaconess Hospital, Harvard Medical School, 330 Brookline Avenue, Boston, MA, 02215, USA

    S. N. Goldberg MD

  3. Department of Radiology, Massachusetts General Hospital, Boston, MA, 02214, USA

    G. S. Gazelle MD (Professor)

Authors
  1. L. Solbiati MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. T. Ierace MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. N. Goldberg MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. Dellanoce MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. L. Cova MD
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. G. S. Gazelle MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Division of Diagnostic and Interventional Radiology, Department of Oncology, University of Pisa, Via Roma 67, I-56125, Pisa, Italy

    C. Bartolozzi MD (Professor and Chairman) & R. Lencioni MD (Professor and Chairman) & 

Rights and permissions

Reprints and permissions

Copyright information

© 1999 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Solbiati, L., Ierace, T., Goldberg, S.N., Dellanoce, M., Cova, L., Gazelle, G.S. (1999). Radiofrequency Thermal Ablation of Liver Metastases. In: Bartolozzi, C., Lencioni, R. (eds) Liver Malignancies. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58641-5_24

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-58641-5_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-63679-0

  • Online ISBN: 978-3-642-58641-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation