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Maturation Phenomenon in Cerebral Ischemia III pp 47–52Cite as

Alterations in Translation Initiation Following Global Brain Ischemia

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Summary

Suppression of protein production has long been noted to occur in the brain following ischemia and reperfusion, and may be an important contributing factor in neuronal death [21]. It is now generally accepted that this depression of protein synthesis is due to inhibition of translation initiation. We will review data showing that phosphorylation of the eukaryotic initiation factor, eIF2, is a key event in the suppression of protein synthesis during reperfusion.

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Authors
  1. D. J. DeGracia
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  2. B. C. White
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  3. G. S. Krause
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Editor information

Editors and Affiliations

  1. Department of Neurosurgery, Musashino Red Cross Hospital, 1-26-1 Kyonan-cho, Musashino-shi, Tokyo 180, Japan

    Umeo Ito

  2. Dipartimenti di Scienze Neurologiche, Università di Roma “La Sapienza”, Viale dell’University 30, 00185, Roma, Italy

    Cesare Fieschi

  3. Istituto Neurologico Mediterraneo, NEUROMED Research Laboratories, Via Atinense 18, 86077, Pozzilli (Isernia), Italy

    Francesco Orzi

  4. Department of Neuropathology, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113 Tokyo, Japan

    Toshihiko Kuroiwa

  5. National Institutes of Health, Laboratory of Neuropathology and Neuroanatomical Sciences, NINDS, Bethesda, MD, 20892-4128, USA

    Igor Klatzo

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© 1999 Springer-Verlag Berlin Heidelberg

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DeGracia, D.J., White, B.C., Krause, G.S. (1999). Alterations in Translation Initiation Following Global Brain Ischemia. In: Ito, U., Fieschi, C., Orzi, F., Kuroiwa, T., Klatzo, I. (eds) Maturation Phenomenon in Cerebral Ischemia III. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-58602-6_6

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  • DOI: https://doi.org/10.1007/978-3-642-58602-6_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-65023-2

  • Online ISBN: 978-3-642-58602-6

  • eBook Packages: Springer Book Archive

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